Physical Sciences and Mathematics Commons^™

Synthesis, Characterization, And Evaluation Of Small Molecule-Based Fluorogenic Probes For The Detection Of Cellular Thiols, Rasika Ranatunga Nawimanage

LSU Doctoral Dissertations

Fluorescence methods for disease diagnosis and detection of important analytes are becoming popular route as a technique, as they offer a simple non-invasive approach. Recently, many novel fluorophores and probes have been reported for selectively and sensitively detecting low abundance biological species in disease pathways. Biological thiols, such as glutathione, cysteine, and homocysteine, along with the smallest member hydrogen sulfide, are key thiol analytes in biological environments, and they play a vital role in living systems by maintaining the redox homeostasis of cells. Alteration of their ratios can cause cellular dysfunction and cell death. Furthermore, thiol levels in cells and …