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Full-Text Articles in Physical Sciences and Mathematics
Purification And Analysis Of Folate-Dye Conjugate, Sravya Mothe
Purification And Analysis Of Folate-Dye Conjugate, Sravya Mothe
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Folate receptor has achieved great importance for use in targeted drug delivery and in vitro and in vivo diagnostic assays. Folate receptor (FR) is over expressed on several cancer cell types and activated macrophages, but exists in relatively low abundance on the surface of non-cancerous tissue and non-inflammatory cells. This unique attribute is the hallmark of folate – targeted methodologies allowing the diagnostic agent and/or drug to be ferried to the specific disease sites while preventing “off target” effects in normal tissues. Although several folate-based dyes have been reported, simple and detailed synthetic and purification methods for these conjugates have …
Folate Nanoparticle Conjugates, Safwat A. Masood
Folate Nanoparticle Conjugates, Safwat A. Masood
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The folate receptor is overexpressed on the surface of numerous cancer cell types including those of the breast, lung, kidney, ovary, and brain. Recent interest has exploded in the use of folate to deliver payloads and imaging agents to folate receptor positive cancer cells based on several positive clinical trials including phase III trials of EC-145, which is poised to become the first folate targeted, FDA approved drug. Given the success of EC-145 and numerous other agents in the pharmaceutical pipeline, there remains a great interest in the exploitation of this technology in the delivery of nanoscale agents to folate …
Evaluation And In Vitro Studies Of Folate-Peg-Biotin, Kuldeep Reddy Vanga
Evaluation And In Vitro Studies Of Folate-Peg-Biotin, Kuldeep Reddy Vanga
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Folate receptor is a membrane bound protein which is highly expressed by cancer cells and macrophages. Folic acid is required for the normal growth of cells and it has been found that rapidly growing cancer cells require high levels of folic acid. Folic acid binds to folate receptors and through receptor mediated transport folate enters cells. This property has been used to synthesize a probe using folate as ligand through polyethylene glycol-Biotin linker. This can be used to attach a drug which is ultimately delivered at the site of infectious cells. The study involved here was to determine how folate …