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Full-Text Articles in Physical Sciences and Mathematics
Chemically And Biologically Responsive Nanoparticle Systems For Biomarker Detection And Combination Cancer Therapy, Neil M. Robertson
Chemically And Biologically Responsive Nanoparticle Systems For Biomarker Detection And Combination Cancer Therapy, Neil M. Robertson
Legacy Theses & Dissertations (2009 - 2024)
The uniqueness and expression of miRNAs as biomarkers in certain cancers has the potential to radically alter the detection, and therefore the treatment, of the disease. Not only are current detection methods time consuming, and not sensitive enough for biomedical applications, but these small RNAs have yet to be fully utilized in treatment. By utilizing different nanomaterials we aimed to create novel nanodevices for the early, sensitive and specific detection of these biomarkers in a minimally invasive way and develop dual drug releasing nanoparticles, which are entirely controllable, to aid in the treatment of resistant cancer phenotypes.