Physical Sciences and Mathematics Commons^™

Synthesis And Characterization Of Cyclic Polypeptoids By Organo-Mediated Controlled Zwitterionic Ring-Opening Polymerization And Development Of Redox-Responsive Polypeptoid Micelles As Drug Delivery Carriers, Ang Li

LSU Doctoral Dissertations

Peptoids are peptidomimetic polymers, which have attracted much attention over the past two decades. They have similar building blocks to peptides, and the similarity makes the backbone of peptoids hydrophilic and biocompatible.1 Two types of peptoid polymers are under development. One is sequence-defined peptoids, which exhibit excellent bioactivities.2 Another one is polypeptoids. The good biocompatibility and highly tunable side chain substituents allow polypeptoids to be used broadly in future biomedical applications. Varying polymer architectures, including linear polymers, cyclic polymers, comb-like polymers, and dendrimers can provide distinctive properties to the polymers. Cyclic polymers employ a cyclic architecture and lack chain ends, …