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Silica Polypeptide-Based Colloids: Physical Properties And Novel Materials, Cornelia Rosu
Silica Polypeptide-Based Colloids: Physical Properties And Novel Materials, Cornelia Rosu
LSU Doctoral Dissertations
The investigation of polypeptide composite particles, PCPs, is described. The production of mesoporous and polycolloid architectures is also addressed. PCPs were prepared by both growing form and grafting to method. They consist of a core made of silica, silica-coated magnetite or silica-coated cobalt. Some of the particles were covalently labeled with fluorescein isothiocyanate. Several polypeptides were chosen for attachment on the core: poly(γ-stearyl-L-glutamate), PSLG, poly(Nε-carbobenzyloxy-L-lysine), PCBL and poly(o-benzyl-L-tyrosine), PBTY. Attachment of a well-characterized alkyne-end terminated PSLG and PCBL to an azide- functionalized particle yielded PCPs with a desired sparse coverage. A blend of techniques such as FTIR, XPS, TEM, HTEM, …
Phase Behavior Of Silica-Polypeptide Hybrid Particles Immersed In Cholesteric Liquid Crystals, Melissa Elizabeth Collins
Phase Behavior Of Silica-Polypeptide Hybrid Particles Immersed In Cholesteric Liquid Crystals, Melissa Elizabeth Collins
LSU Doctoral Dissertations
Silica-polypeptide hybrid particles are core-shell colloids. Established synthetic methods ensure uniformly sized cores and provide the ability to have magnetic or fluorescent inclusions. The polypeptide shell is highly functional in its ability to respond to stimuli through changes in shape and formation of ordered phases above certain concentrations or temperatures. This research explores the interactions of hybrid particles mixed with polypeptides dispersed in solution. Depletion theory, which considers mainly entropic interactions between particles, can be used to explain the phase behavior of colloids. Due to the chemical similarities between the polypeptides attached to the surface and those free in solution, …