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Full-Text Articles in Physical Sciences and Mathematics
Chemotherapeutic Applications Of Rhodamine Based Nanogumbos, Nimisha Bhattarai
Chemotherapeutic Applications Of Rhodamine Based Nanogumbos, Nimisha Bhattarai
LSU Doctoral Dissertations
The work presented in this dissertation employs nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS) for selective chemotherapeutic applications. GUMBOS, similar to ionic liquids, are organic salts consisting of a bulky cationic and anionic moiety. In contrast to ionic liquids, these materials have melting points ranging from 25–250 °C, making them solid phase at room temperature. Similar to ionic liquids, GUMBOS display tunable properties, such as hydrophobicity and solubility, through counter ion variation. These tunable properties provide a variety of applications for these GUMBOS, including selective chemotherapeutics applications. The …
Ionic Liquids And Gumbos For Biomedical And Sensing Applications, Paul Kipkorir Sang Magut
Ionic Liquids And Gumbos For Biomedical And Sensing Applications, Paul Kipkorir Sang Magut
LSU Doctoral Dissertations
This dissertation is a synopsis of advancements in the field of ionic liquids and a group of uniform materials based on organic salts (GUMBOS) in biomedical applications, especially with regard to cancer research. The toxicity of chemotherapeutic agents to normal tissues and drug resistance are a major concern in cancer treatment. In this dissertation, GUMBOS and nanoGUMBOS as well as ionic liquids and nanodroplets are explored as possible chemotherapeutic agents with minimal toxicity to normal cells. In the first part of my dissertation, exploitation of ionic liquid chemistry to modulate toxicity of rhodamine 6G is reported. Rhodamine 6G-based GUMBOS with …
Polymer Microsystems For The Enrichment Of Circulating Tumor Cells And Their Clinical Demonstration, Joyce W. Kamande
Polymer Microsystems For The Enrichment Of Circulating Tumor Cells And Their Clinical Demonstration, Joyce W. Kamande
LSU Doctoral Dissertations
Cancer research is centered on the discovery of new biomarkers that could unlock the obscurities behind the mechanisms that cause cancer or those associated with its spread (i.e., metastatic disease). Circulating tumor cells (CTCs) have emerged as attractive biomarkers for the management of many cancer-related diseases due primarily to the ease of securing them from a simple blood draw. However, their rarity (~1 CTC per mL of whole blood) makes enrichment analytically challenging. Microfluidic systems are viewed as exquisite platforms for the clinical analysis of CTCs due to their ability to be used in an automated fashion, minimizing sample loss …
Phytochemical Analyses Of Bioactive Compounds In The Roots Of Cassia Alata Linn And The Anti-Angiogenic Evaluation Of Rhein As A Therapeutic Agent Against Breast Cancer Cells, Vivian Esther Fernand
Phytochemical Analyses Of Bioactive Compounds In The Roots Of Cassia Alata Linn And The Anti-Angiogenic Evaluation Of Rhein As A Therapeutic Agent Against Breast Cancer Cells, Vivian Esther Fernand
LSU Doctoral Dissertations
The research presented in this dissertation includes the novel phytochemical analysis of root extracts of Cassia alata L. and the anti-angiogenic evaluation of rhein in the treatment of breast cancer. To conduct these studies a combination of analytical techniques were employed, namely, chromatographic, spectroscopic, and bioanalytical. The first part of this research is focused on the phytochemical analysis of C. alata root extracts. A high performance liquid chromatography method was developed and validated for the determination of six phenolic compounds in the root extracts. The investigated compounds were identified by their ultraviolet spectra. Additionally, the presence of these phenolics was …