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Full-Text Articles in Physical Sciences and Mathematics
Triarylmethyl Cation-Catalyzed Three-Component Coupling For The Synthesis Of Unsymmetrical Bisindolylmethanes [Post-Print], William Patterson, Kelly Lucas, Vanessa Jones, Zhenghua Chen, Kevin Bardelski, Melissa Guarino-Hotz, Cheyenne S. Brindle
Triarylmethyl Cation-Catalyzed Three-Component Coupling For The Synthesis Of Unsymmetrical Bisindolylmethanes [Post-Print], William Patterson, Kelly Lucas, Vanessa Jones, Zhenghua Chen, Kevin Bardelski, Melissa Guarino-Hotz, Cheyenne S. Brindle
Faculty Scholarship
An efficient synthesis of unsymmetrical bisindolylmethanes has been accomplished using triarylmethyl cations to catalyze the reaction of N-arylimines with two different indoles. Optimization of the organocatalyst by tuning cation stability allows for excellent single addition selectivity when coupled with p-nitrophenyl imines. The optimal catalyst is commercially available, and the reaction minimizes waste and environmental impact by employing a one-to-one ratio of starting materials. The intermediates can be isolated or used in situ in a one-pot two-step reaction to generate unsymmetrical bisindolylmethanes in high yields. The reaction tolerates a broad range of imines with the highest yields observed for …
Supported Bilayer Membranes For Reducing Cell Adhesion In Microfluidic Devices [Post-Print], Julia R. Clapis, Mengqi Jonathan Fan, Michelle Kovarik
Supported Bilayer Membranes For Reducing Cell Adhesion In Microfluidic Devices [Post-Print], Julia R. Clapis, Mengqi Jonathan Fan, Michelle Kovarik
Faculty Scholarship
The high surface area-to-volume ratio of microfluidic channels makes them susceptible to fouling and clogging when used for biological analyses, including cell-based assays. We evaluated the role of electrostatic and van der Waals interactions in cell adhesion in PDMS microchannels coated with supported lipid bilayers and identified conditions that resulted in minimal cell adhesion. For low ionic strength buffer, optimum results were obtained for a zwitterionic coating of pure egg phosphatidylcholine; for a rich growth medium, the best results were obtained for zwitterionic bilayers or those with slight negative or moderate positive charge from the incorporation of 5-10 mol% egg …