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- ' bipyridine; ascorbic acid; copper; pyridine; unclassified drug; zinc; article; cell assay; cell growth; controlled study; convalescence; cytotoxicity; DNA cleavage; drug activity; human; human cell; IC 50; medical information; neuroblastoma cell; ovary cancer; oxidation; 2 (1)
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- Anticancer drug; Cis-platin; Drug concentration; Drug solutions; Elemental analysis; External surfaces; Internal pores; Mesoporous Silica; Nano-materials; Platinum drugs; Rapid adsorption; Silica nanoparticles; Slow release; Supernatants; Surfactant assemblies; Surfactant molecules; TEM; Transplatin; UV-vis spectra (1)
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Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
Isomer-Dependent Adsorption And Release Of Cis- And Trans-Platin Anticancer Drugs By Mesopomus Silica Nanoparticles, Zhimin Tao, Youwei Xie, Jerry Goodisman, Tewodros Asefa
Isomer-Dependent Adsorption And Release Of Cis- And Trans-Platin Anticancer Drugs By Mesopomus Silica Nanoparticles, Zhimin Tao, Youwei Xie, Jerry Goodisman, Tewodros Asefa
Chemistry - All Scholarship
We report on adsorption and release of the anticancer drugs cisplatin and transplatin from mesoporous silica nanomaterials, emphasizing the differences between cisplatin and its much less toxic isomer. Two types of particles, M.CM-41 and SBA-IS, were used, either as just synthesized or after calcination to remove the templates. The particles were characterized by TEM, nitrogen physisorption, and elemental analysis. The UV-vis spectra of cisplatin and transplatin were obtained and the intensities of several bands (205-210 nm, 210-220 nm, 220-235 nm, and 300-330 nm) were found proportional to drug concentrations, allowing their use for measuring drug concentration. To evaluate drug adsorption …
Noninvasive, In-Vivo, Tissue Modulated Near Infrared Spectroscopy Of Fingertips: Resonance Raman Spectrum Of Human Hemoglobin, Bin Deng, Jerry Goodisman, George Shaheen, Rebecca J. Bussjager, Joseph Chaiken
Noninvasive, In-Vivo, Tissue Modulated Near Infrared Spectroscopy Of Fingertips: Resonance Raman Spectrum Of Human Hemoglobin, Bin Deng, Jerry Goodisman, George Shaheen, Rebecca J. Bussjager, Joseph Chaiken
Chemistry - All Scholarship
Tissue modulation refers to using external stimuli such as mechanical pressure and temperature to produce various spatiotemporal distributions of blood and conceivably other fluids in tissues. Having the capacity to execute tissue modulation1 allows forms of difference spectroscopy to be used to isolate spectroscopic signals from specific components of the tissues noninvasively and in vivo. In the case of human fingertips we can think of the tissues present in the probed volume as being static tissue, plasma and red blood cells (RBCs). Static tissues deform under mechanical pressure based tissue modulation and the only possible fluid motions2 involve plasma …
On Probing Human Fingertips In Vivo Using Near-Infrared Light: Model Calculations, Jerry Goodisman, Joseph Chaiken
On Probing Human Fingertips In Vivo Using Near-Infrared Light: Model Calculations, Jerry Goodisman, Joseph Chaiken
Chemistry - All Scholarship
We probe volar-side fingertip capillary beds with nearinfrared laser light and collect Raman, Rayleigh, and Mie scattered light and fluorescence. The results are interpreted using radiation transfer theory in the single-scattering approximation. The surface topography of the skin is modeled using the Fresnel equations. The skin is treated as a three-layer material, with a mean-field treatment of tissue composition and related optical properties. The model, with a reasonable choice of tissue parameters, gives a remarkably accurate account of the features of actual measurements. It predicts the optimal values for the incident angle of the laser beam and the distance between …
Cytotoxicity Of Cu(Ii) And Zn(Ii) 2,2′-Bipyridyl Complexes: Dependence Of Ic 50 On Recovery Time, Yi Shi, Bonnie B. Toms, Namrata Dixit, Jerry Goodisman, James C. Dabrowiak
Cytotoxicity Of Cu(Ii) And Zn(Ii) 2,2′-Bipyridyl Complexes: Dependence Of Ic 50 On Recovery Time, Yi Shi, Bonnie B. Toms, Namrata Dixit, Jerry Goodisman, James C. Dabrowiak
Chemistry - All Scholarship
We measure the cytotoxicity of three metal complexes containing the 2,2′-bypyridine ligand, Cu(bpy)(NCS) 2, 1, [Cu(bpy) 2(H 2O)](PF 6) 2, 2, and Zn(bpy) 2(NCS) 2, 3, toward neuroblastoma cells (SK-N-SH) and ovarian cancer cells (OVCAR-3) using two different cell assays. The cells were exposed to various concentrations of the compounds for 1 h and the percent inhibition of cell growth, I, measured for various times after exposure, i.e., as a function of the recovery time t. After developing the theory showing the relationship between I and t, the cytotoxicity data were analyzed to …
Cytotoxicity Of Cu(Ii) And Zn(Ii) 2,2′-Bipyridyl Complexes: Dependence Of Ic_50 On Recovery Time, Yi Shi, Bonnie B. Toms, Namrata Dixit, Jerry Goodisman, James C. Dabrowiak
Cytotoxicity Of Cu(Ii) And Zn(Ii) 2,2′-Bipyridyl Complexes: Dependence Of Ic_50 On Recovery Time, Yi Shi, Bonnie B. Toms, Namrata Dixit, Jerry Goodisman, James C. Dabrowiak
Chemistry - All Scholarship
We measure the cytotoxicity of three metal complexes containing the 2,2′-bypyridine ligand, Cu(bpy)(NCS)2, 1, [Cu(bpy)2(H2O)](PF6)2, 2, and Zn(bpy)2(NCS)2, 3, toward neuroblastoma cells (SKN- SH) and ovarian cancer cells (OVCAR-3) using two different cell assays. The cells were exposed to various concentrations of the compounds for 1 h and the percent inhibition of cell growth, I, measured for various times after exposure, i.e., as a function of the recovery time t. After developing the theory showing the relationship between I and t, the cytotoxicity data were analyzed to reveal that the two copper complexes, 1 and 2, cause the cells to …
Mesoporous Silica Microparticles Enhance The Cytotoxicity Of Anticancer Platinum Drugs, Zhimin Tao, Bonnie Toms, Jerry Goodisman, Tewodros Asefa
Mesoporous Silica Microparticles Enhance The Cytotoxicity Of Anticancer Platinum Drugs, Zhimin Tao, Bonnie Toms, Jerry Goodisman, Tewodros Asefa
Chemistry - All Scholarship
We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting …