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Full-Text Articles in Physical Sciences and Mathematics
G-Ruption: The Third International Meeting On G-Quadruplex And G-Assembly, Liliya A. Yatsunyk, T. M. Bryan, F. B. Johnson
G-Ruption: The Third International Meeting On G-Quadruplex And G-Assembly, Liliya A. Yatsunyk, T. M. Bryan, F. B. Johnson
Chemistry & Biochemistry Faculty Works
A three and a half day conference focusing on nucleic acid structures called G-quadruplexes (G4s) and other guanine-based assemblies was held in Sorrento. Italy (June 28-July 1, 2011) and featured 35 invited talks and over 89 posters. The G-quadruplex field continues to expand at an explosive rate with the emergence of new connections to biology, chemistry, physics, and nanotechnology. Following the trend established by the previous two international G4 meetings, the conference touched upon all these areas and facilitated productive exchanges of ideas between researchers from all over the world.
Proposed Coherent Trapping Of A Population Of Electrons In A C60 Molecule Induced By Laser Excitation, Thomas George, G.P. Zhang
Proposed Coherent Trapping Of A Population Of Electrons In A C60 Molecule Induced By Laser Excitation, Thomas George, G.P. Zhang
Chemistry & Biochemistry Faculty Works
This Letter demonstrates the possibility of generating coherent population trapping in C60. Similar to a three-level Λ system, C60 has a forbidden transition between the highest occupied molecular orbital (HOMO) (|a⟩) and the lowest unoccupied molecular orbital (LUMO) (|c⟩), but a dipole-allowed transition between HOMO and LUMO+1 (|b⟩) and between |b⟩ and |c⟩. We employ two cw laser fields, one coupling and one probe. The strong coupling field is switched on first to resonantly excite the transition between |b⟩ and |c⟩. After a delay, the probe is switched on; the coherent interaction between the coupling and probe fields traps the …
Interaction Of Human Telomeric Dna With N-Methyl Mesoporphyrin Ix, John Michael Nicoludis , '12, Steven Paul Barrett , '13, J.-L. Mergny, Liliya A. Yatsunyk
Interaction Of Human Telomeric Dna With N-Methyl Mesoporphyrin Ix, John Michael Nicoludis , '12, Steven Paul Barrett , '13, J.-L. Mergny, Liliya A. Yatsunyk
Chemistry & Biochemistry Faculty Works
The remarkable selectivity of N-methyl mesoporphyrin IX (NMM) for G-quadruplexes (GQs) is long known, however its ability to stabilize and bind GQs has not been investigated in detail. Through the use of circular dichroism, UV-visible spectroscopy and fluorescence resonance energy transfer (FRET) melting assay we have shown that NMM stabilizes human telomeric DNA dAG(3)(TTAG(3))(3) (Tel22) and is selective for its parallel conformation to which it binds in 1:1 stoichiometry with a binding constant of similar to 1.0 x 10(5) M-1. NMM does not interact with an antiparallel conformation of Tel22 in sodium buffer and is the second example in the …
Synthesis Of Some Aminopicolinic Acids, Alicia Beatty, Ramadan Bawa
Synthesis Of Some Aminopicolinic Acids, Alicia Beatty, Ramadan Bawa
Chemistry & Biochemistry Faculty Works
Some aminopicolinic acid derivatives have been synthesized and fully characterized. These pyridine derivatives were 4-aminopicolinic acid, 4-(4-aminophenylethynyl) picolinic acid and 4-(3-aminophenylethynyl) picolinic acid. In addition to these compounds, other substituted picolinic acids were made throughout the synthetic paths.
2-Allylphenyl Glycosides As Complementary Building Blocks For Oligosaccharide And Glycoconjugate Synthesis, Hemali Premathilake, Alexei Demchenko
2-Allylphenyl Glycosides As Complementary Building Blocks For Oligosaccharide And Glycoconjugate Synthesis, Hemali Premathilake, Alexei Demchenko
Chemistry & Biochemistry Faculty Works
The O-allylphenyl (AP) anomeric moiety was investigated as a new leaving group that can be activated for chemical glycosylation under a variety of conditions, through both direct and remote pathways. Differentiation between the two activation pathways was achieved in a mechanistic study. The orthogonal-type activation of the AP moiety along with common thioglycosides allows for the execution of efficient oligosaccharide assembly.