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Full-Text Articles in Physical Sciences and Mathematics
Visible Light-Triggered Carbon Monoxide-Releasing Molecules, Marina Popova
Visible Light-Triggered Carbon Monoxide-Releasing Molecules, Marina Popova
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Carbon monoxide (CO) is now well established as one of the signaling molecules in higher organisms, including humans. Due to its physiological roles, CO is now accepted as a potential therapeutic agent. The use of CO gas has been studied in multiple clinical trials. Vasodilation, anti-inflammatory, anti-apoptotic, anti-proliferative and cytoprotective effects are just a few of the pharmacological actions attributed to CO gas in various models of diseases. Use of inhaled CO gas as a therapeutic has many limitations which necessitate the development of a new approach for CO delivery. In order to handle CO safely, compounds that release CO …
3-Hydroxyflavones And 3-Hydroxy-4-Oxoquinolines As Carbon Monoxide-Releasing Molecules, Tatiana Soboleva, Lisa M. Berreau
3-Hydroxyflavones And 3-Hydroxy-4-Oxoquinolines As Carbon Monoxide-Releasing Molecules, Tatiana Soboleva, Lisa M. Berreau
Chemistry and Biochemistry Faculty Publications
Carbon monoxide-releasing molecules (CORMs) that enable the delivery of controlled amounts of CO are of strong current interest for applications in biological systems. In this review, we examine the various conditions under which CO is released from 3-hydroxyflavones and 3-hydroxy-4-oxoquinolines to advance the understanding of how these molecules, or derivatives thereof, may be developed as CORMs. Enzymatic pathways from quercetin dioxygenases and 3-hydroxy-4-oxoquinoline dioxygenases leading to CO release are examined, along with model systems for these enzymes. Base-catalyzed and non-redox-metal promoted CO release, as well as UV and visible light-driven CO release from 3-hydroxyflavones and 3-hydroxy-4-oxoquinolines, are summarized. The visible …