Physical Sciences and Mathematics Commons^™

A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba, Thomas Alexander

Electronic Theses and Dissertations

In this thesis, we are interested in finding the best drugs that can be repurposed for the disease and able to find the adverse effects such drugs that are FDA-Approved. Developing an effective drug can be a time-consuming and expensive crucible method. Network-based machine learning methods are used for predicting a given drug for A that can be used for B. It aims at finding new indications for already existing drugs and therefore increases the available therapeutic choices at a fraction of the cost of new drug development. The perturbation gene expression data corresponding to the MCF7 cell line was …