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Full-Text Articles in Physical Sciences and Mathematics
Substrate Analogs For Characterizing The Substrate Tolerance Of S. Pneumoniae Srta, Orion Banks
Substrate Analogs For Characterizing The Substrate Tolerance Of S. Pneumoniae Srta, Orion Banks
Graduate Student Symposium
Bacterial sortases have been widely studied for their usefulness in protein modification, however, the variable substrate specificity and activity between homologs of these enzymes is not yet fully characterized. To attempt to further understand sorting signal recognition, we are working towards a substrate bound structure of sortase A from Streptococcus pneumoniae (SrtApneu). This enzyme displays a wide tolerance for alternate amino acids within the canonical LPXTG sorting motif. Our strategy involves a non-cleavable substrate analog that can be docked into the active site, allowing for elucidation of a structure displaying the key contacts that allow the enzyme …
Characterization Of Α-Anomeric Damaged Dna In Complex With Endonuclease Iv Using Fluorescence Resonance Energy Transfer (Fret), Beatrice Edjah
Characterization Of Α-Anomeric Damaged Dna In Complex With Endonuclease Iv Using Fluorescence Resonance Energy Transfer (Fret), Beatrice Edjah
Georgia State Undergraduate Research Conference
No abstract provided.
Characterization Of Active Site Residues In Class I Nitronate Monooxygenase From Pseudomonas Aeruginosa Pao1, Christopher Aguillon
Characterization Of Active Site Residues In Class I Nitronate Monooxygenase From Pseudomonas Aeruginosa Pao1, Christopher Aguillon
Georgia State Undergraduate Research Conference
No abstract provided.
Hydration Site Of Cyclophilin A And Its Allosteric Effects On The Enzyme's Function, Abdullah Shouaib, Jonathan Lopez
Hydration Site Of Cyclophilin A And Its Allosteric Effects On The Enzyme's Function, Abdullah Shouaib, Jonathan Lopez
Georgia State Undergraduate Research Conference
No abstract provided.
Docking Studies Of Isoform-Selectivity Of Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors, Kaitlin Goettsch
Docking Studies Of Isoform-Selectivity Of Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors, Kaitlin Goettsch
UNO Student Research and Creative Activity Fair
Phosphatidylinositol 3-kinases (PI3Ks) and their related pathways are reputed targets for drug-based anticancer therapies. Mutations in PI3K genes, expression, and pathways are frequent among multiple cancer types. Four isoforms of PI3Ks exist: α, β, γ, & δ and studies have identified several ligands for each isoform which are capable of serving as inhibitory therapeutic compounds. However, the biochemical efficacy of these molecules varies and the isoform selectivity is not well understood. In this study, we applied in silico docking methods and free energy calculation methods to estimate the binding of reported PI3K ligands against 5 PI3K structures: PI3Kα (PBD ID: …