Physical Sciences and Mathematics Commons^™

Development Of A One-Pot Allylation And Claisen Rearrangement Of Acetaminophen By Applying Microwave Radiation, Brandon R. Tessier

Landmark Conference Summer Research Symposium

The Claisen rearrangement is a widely applicable organic reaction that involves the shift of a sigma bond across the pi-system of an allyl vinyl ether to produce allylated phenols. In this project, we aim to develop a microwave assisted allylation of a phenol, followed by a subsequent Claisen rearrangement in one pot. The goals of this project are three-fold. First, we aim to accelerate these reactions using microwave assisted organic synthesis because to date, microwave technology has been sparsely used in Claisen chemistry. Second, we aim to perform these reactions in a single pot, enhancing the simplicity and elegance of …