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Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Atomic, Molecular and Optical Physics
City University of New York (CUNY)
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Full-Text Articles in Physical Sciences and Mathematics
Quantum Optical Interferometry And Quantum State Engineering, Richard J. Birrittella Jr
Quantum Optical Interferometry And Quantum State Engineering, Richard J. Birrittella Jr
Dissertations, Theses, and Capstone Projects
We highlight some of our research done in the fields of quantum optical interferometry and quantum state engineering. We discuss the body of work for which our research is predicated, as well as discuss some of the fundamental tenants of the theory of phase estimation. We do this in the context of quantum optical interferometry where our primary interest lies in the calculation of the quantum Fisher information as it has been shown that the minimum phase uncertainty obtained, the quantum Cramer-Rao bound, is saturated by parity-based detection methods. We go on to show that the phase uncertainty one obtains …
Second Harmonic Generation – A Novel Approach In Retinal Imaging, Denis Y. Sharoukhov
Second Harmonic Generation – A Novel Approach In Retinal Imaging, Denis Y. Sharoukhov
Dissertations, Theses, and Capstone Projects
Here we present the utilization of Second Harmonic Generation (SHG) for label-free imaging of microtubules (MTs) in the retinal nerve fiber layer (RNFL). MTs are an important part of axonal cytoskeleton, providing structural support and serving as a railroad in intracellular transport. We demonstrate the application of SHG microscopy to the following studies: 1) Can changes in MT conformation be detected when treated with a stabilizing drug (Taxol); 2) if disruption in MT precedes loss of axons in a mouse model of glaucoma (DBA/2J); and 3) if elevated levels of intraocular pressure affect MT integrity. Our results validate SHG imaging …