Physical Sciences and Mathematics Commons^™

D1 Dopamine Receptor Signaling Is Modulated By The R7 Rgs Protein Eat-16 And The R7 Binding Protein Rsbp-1 In Caenoerhabditis Elegans Motor Neurons, K. A. Wani, M. Catanese, R. Normantowicz, M Herd, K. N. Maher, Daniel Chase

Daniel Chase

Dopamine signaling modulates voluntary movement and reward-driven behaviors by acting through G protein-coupled receptors in striatal neurons, and defects in dopamine signaling underlie Parkinson's disease and drug addiction. Despite the importance of understanding how dopamine modifies the activity of striatal neurons to control basal ganglia output, the molecular mechanisms that control dopamine signaling remain largely unclear. Dopamine signaling also controls locomotion behavior in Caenorhabditis elegans. To better understand how dopamine acts in the brain we performed a large-scale dsRNA interference screen in C. elegans for genes required for endogenous dopamine signaling and identified six genes (eat-16, rsbp-1, unc-43, flp-1, grk-1, …