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Full-Text Articles in Physical Sciences and Mathematics
Cytoplasmic Dynein Binding, Run Length, And Velocity Are Guided By Long-Range Electrostatic Interactions, Lin Li, Joshua Alper, Emil Alexov
Cytoplasmic Dynein Binding, Run Length, And Velocity Are Guided By Long-Range Electrostatic Interactions, Lin Li, Joshua Alper, Emil Alexov
Publications
Dyneins are important molecular motors involved in many essential biological processes, including cargo transport along microtubules, mitosis, and in cilia. Dynein motility involves the coupling of microtubule binding and unbinding to a change in the configuration of the linker domain induced by ATP hydrolysis, which occur some 25 nm apart. This leaves the accuracy of dynein stepping relatively inaccurate and susceptible to thermal noise. Using multi-scale modeling with a computational focusing technique, we demonstrate that the microtubule forms an electrostatic funnel that guides the dynein’s microtubule binding domain (MTBD) as it finally docks to the precise, keyed binding location on …
Ion Transport Through Macrocapillaries – Oscillations Due To Charge Patch Formation, Dhruva Kulkarni, L.A.M. Lyle, Chad E. Sosolik
Ion Transport Through Macrocapillaries – Oscillations Due To Charge Patch Formation, Dhruva Kulkarni, L.A.M. Lyle, Chad E. Sosolik
Publications
We present results on ion transport through large bore capillaries (macrocapillaries) that probe both the geometric and ion-guided aspects of this ion delivery mechanism. We have demonstrated that guiding in macrocapillaries exhibits position- and angle-dependent transmission properties which are directly related to the capillary material (either metal or insulator) and geometry. Specifically, we have passed 1 keV Rb+ ions through glass and metal macrocapillaries, and have observed oscillations for the transmitted ion current passing through the insulating capillaries. Straightforward calculations show that these oscillations can be attributed to beam deflections from charge patches that form on the interior walls …