Physical Sciences and Mathematics Commons^™

Flow Anisotropy Due To Thread-Like Nanoparticle Agglomerations In Dilute Ferrofluids, Alexander Cali, Wah-Keat Lee, A. David Trubatch, Philip Yecko

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Improved knowledge of the magnetic field dependent flow properties of nanoparticle-based magnetic fluids is critical to the design of biomedical applications, including drug delivery and cell sorting. To probe the rheology of ferrofluid on a sub-millimeter scale, we examine the paths of 550 μm diameter glass spheres falling due to gravity in dilute ferrofluid, imposing a uniform magnetic field at an angle with respect to the vertical. Visualization of the spheres’ trajectories is achieved using high resolution X-ray phase-contrast imaging, allowing measurement of a terminal velocity while simultaneously revealing the formation of an array of long thread-like accumulations of magnetic …

Dynamic Child Growth Prediction: A Comparative Methods Approach, Andrada Ivanescu, Ciprian M. Crainiceanu, William Checkley

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

We introduce a class of dynamic regression models designed to predict the future of growth curves based on their historical dynamics. This class of models incorporates both baseline and time-dependent covariates, start with simple regression models and build up to dynamic function-on-function regressions. We compare the performance of the dynamic prediction models in a variety of signal-to-noise scenarios and provide practical solutions for model selection. We conclude that (a) prediction performance increases substantially when using the entire growth history relative to using only the last and first observation; (b) smoothing incorporated using functional regression approaches increases prediction performance; and (c) …

Hemodynamic Characteristics Of Ruptured And Unruptured Multiple Aneurysms At Mirror And Ipsilateral Locations, Ravi Doddasomayajula, Bong Jae Chung, Fernando Mut, Carlos M. Jimenez, Farid Hamzei-Sichani, Christopher M. Putman, Juan R. Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

BACKGROUND AND PURPOSE: Different hemodynamic patterns have been associated with aneurysm rupture. The objective was to test whether hemodynamic characteristics of the ruptured aneurysm in patients with multiple aneurysms were different from those in unruptured aneurysms in the same patient.

MATERIALS AND METHODS: Twenty-four mirror and 58 ipsilateral multiple aneurysms with 1 ruptured and the others unruptured were studied. Computational fluid dynamics models were created from 3D angiographies. Case-control studies of mirror and ipsilateral aneurysms were performed with paired Wilcoxon tests.

RESULTS: In mirror pairs, the ruptured aneurysm had more oscillatory wall shear stress (P = .007) than the …

Entropy Production In A Fluid-Solid System Far From Thermodynamic Equilibrium, Bong Jae Chung, Blas Ortega, Ashuwin Vaidya

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Abstract.: The terminal orientation of a rigid body in a moving fluid is an example of a dissipative system, out of thermodynamic equilibrium and therefore a perfect testing ground for the validity of the maximum entropy production principle (MaxEP). Thus far, dynamical equations alone have been employed in studying the equilibrium states in fluid-solid interactions, but these are far too complex and become analytically intractable when inertial effects come into play. At that stage, our only recourse is to rely on numerical techniques which can be computationally expensive. In our past work, we have shown that the MaxEP is a …

Angioarchitectures And Hemodynamic Characteristics Of Posterior Communicating Artery Aneurysms And Their Association With Rupture Status, Bong Jae Chung, Ravi Doddasomayajula, Fernando Mut, Felicitas Detmer, Michael Pritz, Farid Hamzei-Sichani, Waleed Brinjikji, David F. Kallmes, Carlos M. Jimenez, Christopher Putman, Juan Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

BACKGROUND AND PURPOSE: Intracranial aneurysms originating at the posterior communicating artery are known to have high rupture risk compared with other locations. We tested the hypothesis that different angioarchitectures (ie, branch point configuration) of posterior communicating artery aneurysms are associated with aneurysm hemodynamics, which in turn predisposes aneurysms to rupture.

MATERIALS AND METHODS: A total of 313 posterior communicating artery aneurysms (145 ruptured, 168 unruptured) were studied with image-based computational fluid dynamics. Aneurysms were classified into different angioarchitecture types depending on the location of the aneurysm with respect to parent artery bifurcation. Hemodynamic characteristics were compared between ruptured and unruptured …

Fluid Dynamics Of Watercolor Painting : Experiments And Modelling, David Edward Baron

Theses, Dissertations and Culminating Projects

In his classic study in 1908, A.M. Worthington gave a thorough account of splashes and their formation through visualization experiments. In more recent times, there has been renewed interest in this subject, and much of the underlying physics behind Worthington's experiments has now been clarified. One specific set of such recent studies, which motivates this thesis, concerns the fluid dynamics behind Jackson Pollock's drip paintings. The physical processes and the mathematical structures hidden in his works have received serious attention and have made the scientific pursuit of art a compelling area of exploration. Our current work explores the interaction of …

Tri-Ponderal Mass Index Vs Body Mass Index In Estimating Body Fat During Adolescence, Courtney M. Peterson, Haiyan Su, Diana Thomas, Moonseong Heo, Amir Golnabi, Angelo Pietrobelli, Steven B. Heymsfield

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Importance Body mass index (BMI) is used to diagnose obesity in adolescents worldwide, despite evidence that weight does not scale with height squared in adolescents. To account for this, health care providers diagnose obesity using BMI percentiles for each age (BMI z scores), but this does not ensure that BMI is accurate in adolescents.

Objective To compare the accuracy of BMI vs other body fat indices of the form body mass divided by heightⁿ in estimating body fat levels in adolescents.

Design, Setting, and Participants Cross-sectional data from the 1999 to 2006 US National Health and Nutrition Examination Survey …

Understanding Angiography-Based Aneurysm Flow Fields Through Comparison With Computational Fluid Dynamics, Juan R. Cebral, F. Mut, Bong Jae Chung, L. Spelle, J. Moret, F. Van Nijnatten, D. Ruijters

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

BACKGROUND AND PURPOSE: Hemodynamics is thought to be an important factor for aneurysm progression and rupture. Our aim was to evaluate whether flow fields reconstructed from dynamic angiography data can be used to realistically represent the main flow structures in intracranial aneurysms. MATERIALS AND METHODS: DSA-based flow reconstructions, obtained during interventional treatment, were compared qualitatively with flow fields obtained from patient-specific computational fluid dynamics models and quantitatively with projections of the computational fluid dynamics fields (by computing a directional similarity of the vector fields) in 15 cerebral aneurysms. RESULTS: The average similarity between the DSA and the projected computational fluid …

Rainbow Perfect Matchings And Hamilton Cycles In The Random Geometric Graph, Deepak C. Bal, Patrick Bennett, Xavier Pérez‐Giménez, Paweł Prałat

Department of Mathematics Facuty Scholarship and Creative Works

Given a graph on n vertices and an assignment of colours to the edges, a rainbow Hamilton cycle is a cycle of length n visiting each vertex once and with pairwise different colours on the edges. Similarly (for even n) a rainbow perfect matching is a collection of independent edges with pairwise different colours. In this note we show that if we randomly colour the edges of a random geometric graph with sufficiently many colours, then a.a.s. the graph contains a rainbow perfect matching (rainbow Hamilton cycle) if and only if the minimum degree is at least 1 (respectively, …

Hemodynamic Differences Between Unstable And Stable Unruptured Aneurysms Independent Of Size And Location: A Pilot Study, Waleed Brinjikji, Bong Jae Chung, Carlos Jimenez, Christopher Putman, David F. Kallmes, Juan R. Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Background While clinical and angiographic risk factors for intracranial aneurysm instability are well established, it is reasonable to postulate that intra-aneurysmal hemodynamics also have a role in aneurysm instability. Objective To identify hemodynamic characteristics that differ between radiologically unstable and stable unruptured intracranial aneurysms. Materials and methods 12 pairs of unruptured intracranial aneurysms with a 3D rotational angiographic set of images and followed up longitudinally without treatment were studied. Each pair consisted of one stable aneurysm (no change on serial imaging) and one unstable aneurysm (demonstrated growth of at least 1 mm diameter or ruptured during follow-up) of matching size …

Differences In Hemodynamics And Rupture Rate Of Aneurysms At The Bifurcation Of The Basilar And Internal Carotid Arteries, Ravi Doddasomayajula, Bong Jae Chung, Farid Hamzei-Sichani, Christopher M. Putman, Juan Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

BACKGROUND AND PURPOSE: Cerebral aneurysms in the posterior circulation are known to have a higher rupture risk than those in the anterior circulation. We sought to test the hypothesis that differences in hemodynamics can explain the difference in rupture rates.

MATERIALS AND METHODS: A total of 117 aneurysms, 63 at the tip of the basilar artery (27 ruptured, 36 unruptured, rupture rate = 43%) and 54 at the bifurcation of the internal carotid artery (11 ruptured, 43 unruptured, rupture rate = 20%) were analyzed with image-based computational fluid dynamics. Several hemodynamic variables were compared among aneurysms at each location and …

Metastable States In Terminal Orientation Of Hinged Symmetric Bodies In A Flow, Doralia Castillo, Bong Jae Chung, Klaus Schnitzer, Karina Soriano, Haiyan Su, Ashuwin Vaidya

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Symmetric bodies such as cylinders and spheroidal bodies, in their terminal stable states, are long known to have their long axis align themselves perpendicular to the direction of the flow. This property has been confirmed in primarily sedimentation based theoretical, experimental and numerical techniques and the transition to a terminal stable state is believed to coincide with the onset of significant inertial effects in the flow. However, the threshold at which this transition occurs is yet unknown. We conduct modified experiments with hinged bodies and a CFD study to examine the nature of the transition of prolate spheroids and cylinders …

On The Three Dimensional Interaction Between Flexible Fibers And Fluid Flow, Bogdan Nita, Ryan Allaire

Department of Mathematics Facuty Scholarship and Creative Works

In this paper we discuss the deformation of a flexible fiber clamped to a spherical body and immersed in a flow of fluid moving with a speed ranging between 0 and 50 cm/s by means of three dimensional numerical simulation developed in COMSOL . The effects of flow speed and initial configuration angle of the fiber relative to the flow are analyzed. A rigorous analysis of the numerical procedure is performed and our code is benchmarked against well established cases. The flow velocity and pressure are used to compute drag forces upon the fiber. Of particular interest is the behavior …

Flow Conditions In The Intracranial Aneurysm Lumen Are Associated With Inflammation And Degenerative Changes Of The Aneurysm Wall, J. Cebral, E. Ollikainen, Bong Jae Chung, F. Mut, V. Sippola, B. R. Jahromi, R. Tulamo, J. Hernesniemi, M. Niemelä, A. Robertson, J. Frösen

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

BACKGROUND AND PURPOSE: Saccular intracranial aneurysm is a common disease that may cause devastating intracranial hemorrhage. Hemodynamics, wall remodeling, and wall inflammation have been associated with saccular intracranial aneurysm rupture.Weinvestigated how saccular intracranial aneurysm hemodynamics is associated with wall remodeling and inflammation of the saccular intracranial aneurysm wall. MATERIALS AND METHODS: Tissue samples resected during a saccular intracranial aneurysm operation (11 unruptured, 9 ruptured) were studied with histology and immunohistochemistry. Patient-specific computational models of hemodynamics were created from preoperative CT angiographies. RESULTS: More stable and less complex flows were associated with thick, hyperplastic saccular intracranial aneurysm walls, while slower flows …