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Full-Text Articles in Physical Sciences and Mathematics
Raising Student Awareness Of Environmental Issues Via Writing Assignments With Differential Equations, Michelle L. Ghrist
Raising Student Awareness Of Environmental Issues Via Writing Assignments With Differential Equations, Michelle L. Ghrist
CODEE Journal
In this paper, I discuss two environmentally-focused writing assignments that I developed and implemented in recent integral calculus and differential equations courses. These models of carbon storage and PCB’s in a river provide interesting applications of one-compartment mixing problems. The assignments were intended to focus student attention on sustainability concerns while also developing other essential skills. I discuss these assignments and their effect on my students’ technical writing and environmental awareness. Detailed introductory instructions and mostly complete solutions to these assignments appear in the appendices, to include sample student work.
Social Aggregation In Pea Aphids: Experiment And Random Walk Modeling, Christa Nilsen, John Paige, Olivia Warner, Benjamin Mayhew, Ryan Sutley, Matthew Lam '15, Andrew J. Bernoff, Chad M. Topaz
Social Aggregation In Pea Aphids: Experiment And Random Walk Modeling, Christa Nilsen, John Paige, Olivia Warner, Benjamin Mayhew, Ryan Sutley, Matthew Lam '15, Andrew J. Bernoff, Chad M. Topaz
All HMC Faculty Publications and Research
From bird flocks to fish schools and ungulate herds to insect swarms, social biological aggregations are found across the natural world. An ongoing challenge in the mathematical modeling of aggregations is to strengthen the connection between models and biological data by quantifying the rules that individuals follow. We model aggregation of the pea aphid, Acyrthosiphon pisum. Specifically, we conduct experiments to track the motion of aphids walking in a featureless circular arena in order to deduce individual-level rules. We observe that each aphid transitions stochastically between a moving and a stationary state. Moving aphids follow a correlated random walk. …
Mathematical Aids Epidemic Model: Preferential Anti-Retroviral Therapy Distribution In Resource Constrained Countries, Nadia Abuelezam
Mathematical Aids Epidemic Model: Preferential Anti-Retroviral Therapy Distribution In Resource Constrained Countries, Nadia Abuelezam
HMC Senior Theses
HIV/AIDS is one of the largest health problems the world is currently facing. Even with anti-retroviral therapies (ART), many resource-constrained countries are unable to meet the treatment needs of their infected populations. ART-distribution methods need to be created that prevent the largest number of future HIV infections. We have developed a compartment model that tracks the spread of HIV in multiple two-sex populations over time in the presence of limited treatment. The model has been fit to represent the HIV epidemic in rural and urban areas in Uganda. With the model we examine the spread of HIV among urban and …
Optimal Therapy Regimens For Treatment-Resistant Mutations Of Hiv, Weiqing Gu, Helen Moore
Optimal Therapy Regimens For Treatment-Resistant Mutations Of Hiv, Weiqing Gu, Helen Moore
All HMC Faculty Publications and Research
In this paper, we use control theory to determine optimal treatment regimens for HIV patients, taking into account treatment-resistant mutations of the virus. We perform optimal control analysis on a model developed previously for the dynamics of HIV with strains of various resistance to treatment (Moore and Gu, 2005). This model incorporates three types of resistance to treatments: strains that are not responsive to protease inhibitors, strains not responsive to reverse transcriptase inhibitors, and strains not responsive to either of these treatments. We solve for the optimal treatment regimens analytically and numerically. We find parameter regimes for which optimal dosing …
A Mathematical Model For Treatment-Resistant Mutations Of Hiv, Helen Moore, Weiqing Gu
A Mathematical Model For Treatment-Resistant Mutations Of Hiv, Helen Moore, Weiqing Gu
All HMC Faculty Publications and Research
In this paper, we propose and analyze a mathematical model, in the form of a system of ordinary differential equations, governing mutated strains of human immunodeficiency virus (HIV) and their interactions with the immune system and treatments. Our model incorporates two types of resistant mutations: strains that are not responsive to protease inhibitors, and strains that are not responsive to reverse transcriptase inhibitors. It also includes strains that do not have either of these two types of resistance (wild-type virus) and strains that have both types. We perform our analysis by changing the system of ordinary differential equations (ODEs) to …