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Analysis Of Gaba And Glutamate In The Mouse Dorsal Striatum, Stella Wisidagamage
Analysis Of Gaba And Glutamate In The Mouse Dorsal Striatum, Stella Wisidagamage
Wayne State University Theses
ABSTRACT
ANALYSIS OF GABA AND GLUTAMATE IN MICE BRAIN
by
STELLA WISIDAGAMA
May 2011
Advisor: Dr. Tiffany Mathews
Major: Chemistry (Analytical)
Degree: Master of Science
GABA and glutamate are the predominant inhibitory and excitatory amino acid neurotransmitters in the central nervous system (CNS), respectively. However, their altered levels cause several neurological diseases including Parkinson's and Huntington's disease, schizophrenia, and epilepsy. It is important to measure their levels in the extra- and intracellular environments to better understand and develop improved therapeutics that will treat these neurological disorders. The principle aim of this study is to study the impacts of different endogenous …
Nmr Solution Structures Of Two Hairpins Of E. Coli 16s Rrna: The Effects Of Mutations And Chemical Modifications On Structure And Function Of Rrna, Yu Liu
Wayne State University Dissertations
The structures of two functional mutants, the UC (G690U, U697C) and the QM mutants (G690A, G693C, A695C, U697A) of the 690 hairpin of E. coli 16S ribosomal RNA were determined by NMR. The UC mutant and the QM mutant with high biological function are able to fold into structures that are isomorphous with the wild-type 690 hairpin sequence. The structural comparisons among the functional mutants and the wild-type provides structural validation for previously identified specific functional groups that are crucial for maintaining function of the 690 hairpin. The key groups for maintaining the structure and function of the 690 loop …