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The Development Of Apci Mass Spectrometry Based Systems For Quantitative Real-Time Monitoring Of Process-Scale Homogenous And Heterogeneous Reactions, Zhenqian Zhu

Doctoral Dissertations

The dissertation presents solutions to monitor industrial chemical processes quantitatively in real time by mass spectrometry. Chapter 1 presents the background of atmospheric pressure chemical ionization mass spectrometry (APCI-MS). Chapters 2-6 present methods developed based on flow injection analysis coupled to atmospheric pressure chemical ionization mass spectrometry (FIA/APCI-MS) for quantitative real-time monitoring of homogeneous and heterogeneous reactions conducted at molar concentrations.

Chapter 2 introduces auto-sampling FIA/APCI-MS with the ability to overcome potential sample overloading when molar concentration samples were analyzed without sample pretreatment procedures. A homogenous Michael-addition reaction between phenethylamine and acrylonitrile was conducted at room temperature and monitored quantitatively …