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Full-Text Articles in Physical Sciences and Mathematics
Analysis Of Cell Signaling Perturbations In Response To Chronic Localized Infections, Amber Nicole Prince
Analysis Of Cell Signaling Perturbations In Response To Chronic Localized Infections, Amber Nicole Prince
Graduate Theses, Dissertations, and Problem Reports
The tissue-level response to pathogens involves an intricate series of signal transduction events, influenced by immune and healing mediators that alert the host to danger and eliminate the infection. Disruptions to normal signaling events can compromise the host’s ability to respond and lead to the development of chronic infections that cannot be resolved without clinical intervention. Prolonged inflammation due to chronic infection can damage tissues and compromise healing processes, thus, the interactions of immune and healing mediators in signaling cascades are intimately linked to tissue health outcomes. Studying signaling networks relevant to these responses provided a more thorough understanding of …
Investigating Stress Response Across Integrated Biological Systems, Alice A. Han
Investigating Stress Response Across Integrated Biological Systems, Alice A. Han
Graduate Theses, Dissertations, and Problem Reports
The impact that a stressor has on a living system, whether it is on a cellular, organ, or even a whole organism level, can affect the overall health of the system. Monitoring the biochemical response resulting from a stressful experience offers insight into the numerous potential outcomes ranging on the spectrum of survival and death. Accessing this information not only provides a heightened understanding of the biochemical adaptions that occur, but also allows for the development of prediction models (to assess prospective influences of the stressor) or potential therapeutic treatments (to alleviate adverse effects) using measurable, quantifiable, and comparable metrics. …