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Full-Text Articles in Medicine and Health Sciences
Characterization Of Stem And Progenitor Cells In The Dental Pulp Of Erupted And Unerupted Murine Molars, Anamaria Balic, Hector L. Aguila, Melissa J. Caimano, Victor P. Francone, Mina Mina
Characterization Of Stem And Progenitor Cells In The Dental Pulp Of Erupted And Unerupted Murine Molars, Anamaria Balic, Hector L. Aguila, Melissa J. Caimano, Victor P. Francone, Mina Mina
UCHC Articles - Research
In the past few years there have been significant advances in the identification of putative stem cells also referred to as “mesenchymal stem cells” (MSC) in dental tissues including the dental pulp. It is thought that MSC in dental pulp share certain similarities with MSC isolated from other tissues. However, cells in dental pulp are still poorly characterized. This study focused on the characterization of progenitor and stem cells in dental pulps of erupted and unerupted mice molars. Our study showed that dental pulps from unerupted molars contain a significant number of cells expressing CD90+/CD45-, CD117+/CD45-, Sca-1+/CD45- and little if …
Osteopenia In Transgenic Mice With Osteoblast-Targeted Expression Of The Inducible Camp Early Repressor, Taranpreet K. Chandhoke, Yu-Feng Huang, Fei Liu, Gloria A. Gronowicz, Douglas J. Adams, John R. Harrison, Barbara E. Kream
Osteopenia In Transgenic Mice With Osteoblast-Targeted Expression Of The Inducible Camp Early Repressor, Taranpreet K. Chandhoke, Yu-Feng Huang, Fei Liu, Gloria A. Gronowicz, Douglas J. Adams, John R. Harrison, Barbara E. Kream
UCHC Articles - Research
ICER is a member of the CREM family of basic leucine zipper transcription factors that acts as a dominant negative regulator of gene transcription. Four different isoforms of ICER (I, Iγ, II and IIγ) are transcribed from the P2 promoter of the Crem gene. We previously found that each of the ICER isoforms is induced by parathyroid hormone in osteoblasts. The goal of the present study was to assess the function of ICER in bone by overexpressing ICER in osteoblasts of transgenic mice. ICER I and ICER II cDNAs, each containing an N-terminal FLAG epitope tag, were cloned downstream of …