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Full-Text Articles in Medicine and Health Sciences
Whey Protein Supplementation Post Resistance Exercise In Elderly Men Induces Changes In Muscle Mirna's Compared To Resistance Exercise Alone, Randall F. D'Souza, Nina Zeng, James F. Markworth, Vandre C. Figueiredo, Christopher P. Hedges, Aaron C Petersen, Paul A Della Gatta, David Cameron-Smith, Cameron J. Mitchell
Whey Protein Supplementation Post Resistance Exercise In Elderly Men Induces Changes In Muscle Mirna's Compared To Resistance Exercise Alone, Randall F. D'Souza, Nina Zeng, James F. Markworth, Vandre C. Figueiredo, Christopher P. Hedges, Aaron C Petersen, Paul A Della Gatta, David Cameron-Smith, Cameron J. Mitchell
Center for Muscle Biology Faculty Publications
Progressive muscle loss with aging results in decreased physical function, frailty, and impaired metabolic health. Deficits in anabolic signaling contribute to an impaired ability for aged skeletal muscle to adapt in response to exercise and protein feeding. One potential contributing mechanism could be exerted by dysregulation of microRNAs (miRNAs). Therefore, the aim of this study was to determine if graded protein doses consumed after resistance exercise altered muscle miRNA expression in elderly men. Twenty-three senior men (67.9 ± 0.9 years) performed a bout of resistance exercise and were randomized to consume either a placebo, 20 or 40 g of whey …
Local In Vivo Measures Of Muscle Lipid And Oxygen Consumption Change In Response To Combined Vitamin D Repletion And Aerobic Training In Older Adults, D. Travis Thomas, David M. Schnell, Maja Redzic, Mingjun Zhao, Hideat Abraha, Danielle Jones, Howard Brim, Guoqiang Yu
Local In Vivo Measures Of Muscle Lipid And Oxygen Consumption Change In Response To Combined Vitamin D Repletion And Aerobic Training In Older Adults, D. Travis Thomas, David M. Schnell, Maja Redzic, Mingjun Zhao, Hideat Abraha, Danielle Jones, Howard Brim, Guoqiang Yu
Health and Clinical Sciences Faculty Publications
Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL). Male and female subjects aged 60–80 years with a BMI ranging from 18.5–34.9 and vitamin D status of ≤ 32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 × 2 factorial design. Cholecalciferol (Vitamin D3) (10,000 IU × 5 days/week) or placebo was provided for 13 weeks …
The Role Of Sirt1 In Skeletal Muscle Function And Repair Of Older Mice, Mathew J. Myers, Danielle L. Sheperd, Andrya J. Durr, David S. Stanton, Junaith S. Mohamed, John M. Hollander, Stephen E. Alway
The Role Of Sirt1 In Skeletal Muscle Function And Repair Of Older Mice, Mathew J. Myers, Danielle L. Sheperd, Andrya J. Durr, David S. Stanton, Junaith S. Mohamed, John M. Hollander, Stephen E. Alway
Faculty & Staff Scholarship
Background Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked to longevity and has been suggested to confer beneficial effects that counter aging-associated deterioration. Muscle repair is dependent upon satellite cell function, which is reported to be reduced with aging; however, it is not known if this is linked to an aging-suppression of SIRT1. This study tested the hypothesis that Sirtuin 1 (SIRT1) overexpression would increase the extent of muscle repair and muscle function in older mice. Methods We examined satellite cell dependent repair in tibialis anterior, gastrocnemius, and soleus muscles of 13 young wild-type mice (20–30 …