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A Computational Model Of Multiple Interconnected Capillary Modules In Skeletal Muscle, Raashi Vijay
A Computational Model Of Multiple Interconnected Capillary Modules In Skeletal Muscle, Raashi Vijay
Electronic Thesis and Dissertation Repository
Background: Skeletal muscle (SM), with its precise O2 supply-demand matching, is ideal for studying microvascular (MV) function, which is crucial in cardiovascular physiology and disease. Our goal is to gain understanding of SM microcirculation using recent capillary network module (CM) data from rat in a computational model.
Methods: We construct a 4-CM network, with single-vessel equivalents for each CM, three arterioles, and two venules. A two-phase (plasma/RBCs) steady-state model is used to calculate blood flow. An iterative boundary pressure finding method is developed to match flow in CMs.
Results: We validate our flow and pressure models …