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Full-Text Articles in Medicine and Health Sciences
Group Cohesion And Homework Adherence In Multi-Family Group Therapy For Schizophrenia, Frank P. Deane, Joanne Mercer, Anahita Talyarkhan, Gordon Lambert, Judy Pickard
Group Cohesion And Homework Adherence In Multi-Family Group Therapy For Schizophrenia, Frank P. Deane, Joanne Mercer, Anahita Talyarkhan, Gordon Lambert, Judy Pickard
Frank Deane
This study examined the relationship between levels of group cohesion, defined as whole group relationships, and between-session therapeutic homework adherence in a multi-family group therapy (MFGT) for people with schizophrenia. Participants from 18 consenting families attending MFGT groups completed weekly homework adherence ratings, group cohesion and spontaneous between-session activity measures. Levels of group cohesion at each session were compared with measures of scheduled and spontaneous homework adherence reported at the next session. It was hypothesised that higher levels of group cohesion would be related to homework adherence and other spontaneous between-session therapeutic activity completed by group members. Results show higher …
Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang
Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang
Xu-Feng Huang
The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia,particularly with regards to auditory hallucinations. In this study, using in situ quantitative autoradiography in postmortem tissue, we investigated the binding of the [3H]ketanserin to 5-HT2A receptors and [3H] mesulergine to 5-HT2C receptors in the left STG of 8 male schizophrenic patients compared to 8 control subjects. A strong [3H]ketanserin binding was observed in the STG, however there was a very weak [3H] mesulergine binding in the STG. A significant decrease in binding of [3H]ketanserin was clearly observed in schizophrenia patients in comparison with control subjects. There were …
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
Xu-Feng Huang
Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with the synthetic analogue of D9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We measured the impact of this exposure on locomotor activity, anxiety, prepulse inhibition (PPI), body temperature and FosB/DFosB immunohistochemistry. Tolerance to CP55,940-induced hypothermia and locomotor suppression developed more rapidly in Nrg1 HET mice than WT mice. Conversely in the light-dark test, while tolerance to …
Increased Cannabinoid Receptor Density In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Chao Deng
Increased Cannabinoid Receptor Density In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.
Membrane Phospholipid Composition, Alterations In Neurotransmitter Systems And Schizophrenia, Xu-Feng Huang, Chao Deng, Teresa Du Bois
Membrane Phospholipid Composition, Alterations In Neurotransmitter Systems And Schizophrenia, Xu-Feng Huang, Chao Deng, Teresa Du Bois
Xu-Feng Huang
No abstract provided.
No Changes In Densities Of Cannabinoid Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng, Mei Han
No Changes In Densities Of Cannabinoid Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng, Mei Han
Xu-Feng Huang
Objective: In recent years, abnormal changes in the endocannabinoid system have been found in schizophrenia. The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. In this study, we investigated the binding density of cannabinoid CB1 receptors in the STG of schizophrenia patients compared to control subjects. Methods: Quantitative autoradiography was used to investigate the binding densities of [3H] SR141716A (a selective antagonist) and [3H]CP-55940 (an agonist) to the CB1 receptors in the STG. Post-mortem brain tissue was obtained from the NSW Tissue Resource Centre (Australia). Results: Contrasting to previous findings …
Increased Density Of Gabaa Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Increased Density Of Gabaa Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.
Decreased Density Of Muscarinic Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Decreased Density Of Muscarinic Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.
M2/M4 Muscarinic Receptor Binding In The Anterior Cingulate Cortex In Schizophrenia And Mood Disorders, Xu-Feng Huang, Katerina Zavitsanou, Andrew Katsifis, Yinghua Yu
M2/M4 Muscarinic Receptor Binding In The Anterior Cingulate Cortex In Schizophrenia And Mood Disorders, Xu-Feng Huang, Katerina Zavitsanou, Andrew Katsifis, Yinghua Yu
Xu-Feng Huang
No abstract provided.
Ionotropic Glutamate Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia Patients, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Ionotropic Glutamate Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia Patients, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Xu-Feng Huang
No abstract provided.
Rapid Cortico-Limbic Alterations In Ampa Receptor Densities After Administration Of Pcp: Implications For Schizophrenia., Van Nguyen, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, P Ballantyne
Rapid Cortico-Limbic Alterations In Ampa Receptor Densities After Administration Of Pcp: Implications For Schizophrenia., Van Nguyen, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, P Ballantyne
Xu-Feng Huang
Phencyclidine (PCP), a non-competitive NMDA/glutamate receptor antagonist, is a psychotomimetic drug that produces a syndrome in normal humans that resembles schizophrenia. The present study investigated the mechanisms of PCP actions by examining the density of glutamate and muscarinic receptors in the rat brain 4 h after a single injection of PCP. We used receptor autoradiography and [3H]MK801, [3H]AMPA, [3H]pirenzepine and [3H]AFDX384 to target glutamate NMDA, glutamate AMPA and muscarinic M1 and M2 receptors, respectively. The major outcome from the present study was an overall decrease in levels of the glutamate AMPA receptor density (F = 14.5, d.f. = 1, p …
Alterations Of Muscarinic And Gaba Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Stephen Kum Jew
Alterations Of Muscarinic And Gaba Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Stephen Kum Jew
Xu-Feng Huang
No abstract provided.
Immune Factors In The Neuregulin-1 Knockout Mouse Model Of Schizophrenia, P Snikeris, Xu-Feng Huang, Elisabeth T. Frank
Immune Factors In The Neuregulin-1 Knockout Mouse Model Of Schizophrenia, P Snikeris, Xu-Feng Huang, Elisabeth T. Frank
Xu-Feng Huang
No abstract provided.
Changing Staff Attitudes And Empathy For Working With People With Psychosis, H. J. Mcleod, F. P. Deane, B. Hogbin
Changing Staff Attitudes And Empathy For Working With People With Psychosis, H. J. Mcleod, F. P. Deane, B. Hogbin
Frank Deane
Seventy-seven mental health professionals completed a 3-day cognitive behavioural training course for managing hallucinations and delusions in schizophrenia. A questionnaire measuring attitudes and empathy towards working with people who have these symptoms was administered before and after the course. Significant increases in feelings of adequacy, legitimacy, employment related self-esteem, and expectations of work satisfaction were observed after the course and participants displayed high levels of motivation for working with this clinical population at both time points. In addition, the participants showed significant increases in perceived empathy for the experience of hallucinations and delusions. This was a predicted outcome as the …
A Systematic Review Of Interventions To Increase Mental Health Service Use, Jennifer Greene
A Systematic Review Of Interventions To Increase Mental Health Service Use, Jennifer Greene
USF Tampa Graduate Theses and Dissertations
Relatively few pre-treatment interventions to increase out-patient mental health (MH) service use have been created and experimentally tested. Therefore, not only is there limited availability of these interventions, it is uncertain whether existing interventions are effective. Moreover, it is unclear which components of the interventions are effective. To address these gaps in knowledge, a systematic review of pre-treatment interventions was conducted, using the Cochrane Review methodology. Three primary outcomes were evaluated: attendance at any type of out-patient MH visit; number of appointments of any type of out-patient MH visit; and/or initiation and adherence to psychotropic medication. PubMed and PsycINFO databases …
Group Cohesion And Homework Adherence In Multi-Family Group Therapy For Schizophrenia, Frank P. Deane, Joanne Mercer, Anahita Talyarkhan, Gordon Lambert, Judy Pickard
Group Cohesion And Homework Adherence In Multi-Family Group Therapy For Schizophrenia, Frank P. Deane, Joanne Mercer, Anahita Talyarkhan, Gordon Lambert, Judy Pickard
Faculty of Health and Behavioural Sciences - Papers (Archive)
This study examined the relationship between levels of group cohesion, defined as whole group relationships, and between-session therapeutic homework adherence in a multi-family group therapy (MFGT) for people with schizophrenia. Participants from 18 consenting families attending MFGT groups completed weekly homework adherence ratings, group cohesion and spontaneous between-session activity measures. Levels of group cohesion at each session were compared with measures of scheduled and spontaneous homework adherence reported at the next session. It was hypothesised that higher levels of group cohesion would be related to homework adherence and other spontaneous between-session therapeutic activity completed by group members. Results show higher …
The Impact Of Cannabis Use On Cognitive Functioning In Patients With Schizophrenia: A Meta-Analysis Of Existing Findings And New Data In A First-Episode Sample, Murat Yücel, Emre Bora, Daniel I. Lubman, Nadia Solowij, Warrick J. Brewer, Sue M. Cotton, Phillipe Conus, Michael J. Takagi, Alex Fornito, Stephen J. Wood, Patrick D. Mcgorry, Christos Pantelis
The Impact Of Cannabis Use On Cognitive Functioning In Patients With Schizophrenia: A Meta-Analysis Of Existing Findings And New Data In A First-Episode Sample, Murat Yücel, Emre Bora, Daniel I. Lubman, Nadia Solowij, Warrick J. Brewer, Sue M. Cotton, Phillipe Conus, Michael J. Takagi, Alex Fornito, Stephen J. Wood, Patrick D. Mcgorry, Christos Pantelis
Faculty of Health and Behavioural Sciences - Papers (Archive)
Cannabis use is highly prevalent among people with schizophrenia, and coupled with impaired cognition, is thought to heighten the risk of illness onset. However, while heavy cannabis use has been associated with cognitive deficits in long-term users, studies among patients with schizophrenia have been contradictory. This article consists of 2 studies. In Study I, a meta-analysis of 10 studies comprising 572 patients with established schizophrenia (with and without comorbid cannabis use) was conducted. Patients with a history of cannabis use were found to have superior neuropsychological functioning. This finding was largely driven by studies that included patients with a lifetime …