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Full-Text Articles in Medicine and Health Sciences
Magnetic Drug Delivery Of Xanthohumol To Adipocytes Using Ultrasmall Superparamagnetic Iron Oxide Nanoparticles., Irandokht Khaki Najafabadi, Janaiya Samuels, Royce Dansby-Sparks, Srujana Rayalam, Vicky Mody
Magnetic Drug Delivery Of Xanthohumol To Adipocytes Using Ultrasmall Superparamagnetic Iron Oxide Nanoparticles., Irandokht Khaki Najafabadi, Janaiya Samuels, Royce Dansby-Sparks, Srujana Rayalam, Vicky Mody
Research Day
According to the CDC’s National Center for Health Statistics, more than one-third (36.5%) of U.S adults are obese. It is the main risk factor for type-2-diabetes, hypertension, dyslipidemia and atherosclerosis. Nutraceuticals such as Xanthohumol have shown potential to inhibit adipogeneis, however, their bioavailability has remained controversial. Hence there is a need to develop targeted therapy which will increase the concentration of Xanthohumol on adipose tissues. Currently, magnetic drug delivery has been used to develop targeted therapies where conventional therapies have proven to be less effective. Among various types of nanoparticles ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) have found considerable attention …
Phytochemicals Added To The Feed Of Ovariectomized Adult Rats Increase Brown Adipose Activity, Colette N. Miller, Suresh Ambati, Erica Bass, Natalie Hohos, Diane Hartzel, Emily England, Mary Anne Della-Fera, Srujana Rayalam, Clifton A. Baile
Phytochemicals Added To The Feed Of Ovariectomized Adult Rats Increase Brown Adipose Activity, Colette N. Miller, Suresh Ambati, Erica Bass, Natalie Hohos, Diane Hartzel, Emily England, Mary Anne Della-Fera, Srujana Rayalam, Clifton A. Baile
Research Day
Background: Brown adipose tissue (BAT) uncouples respiration, using lipids as an energy source while dissipating heat. Increases in BAT activity are protective against obesity, thus compounds that increase BAT activation may help prevent weight gain. Resveratrol (R) increases BAT activity by upregulating thermogenic genes. As phytochemicals have synergistic properties, our research strategy has included investigation of the efficacy of relatively low concentrations of phytochemical blends on BAT activation. Methods: Previously, we showed that R combined with genistein (G) and quercetin (Q) reduced weight gain in aged ovariectomized (OVX) female rats. In the current study, OVX rats were fed diets containing …