Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Development And Localization Of Spike-Wave Seizures In Animal Models, Damien Jon Ellens
Development And Localization Of Spike-Wave Seizures In Animal Models, Damien Jon Ellens
Yale Medicine Thesis Digital Library
Animal models allow for detailed investigation of neuronal function, particularly invasive localization and developmental studies not possible in humans. This thesis will review the technical challenges of simultaneous EEG-fMRI, and epileptogenesis studies in animal models, including issues related to anesthesia, movement, signal artifact, physiology, electrode compatibility, data acquisition, and data analysis, and review recent findings from simultaneous EEG-fMRI studies in epilepsy and other fields. Original research will be presented on the localization of neuronal networks involved during spike-and-wave seizures in the WAG/Rij rat, a model of human absence epilepsy. Simultaneous EEG-fMRI at 9 Tesla, complimented by parallel electrophysiology, including Multiple …
The Role Of Frizzled-1 And Frizzled-3 In Olfactory Sensory Neuronal Targeting, Mina Safain
The Role Of Frizzled-1 And Frizzled-3 In Olfactory Sensory Neuronal Targeting, Mina Safain
Yale Medicine Thesis Digital Library
THE ROLE OF FRIZZLED-1 AND FRIZZLED-3 IN OLFACTORY SENSORY NEURONAL TARGETING. Mina G. Safain. Department of Neurosurgery, Yale University School of Medicine, New Haven, CT. While most areas of the brain do not exhibit profound neurogenesis or continuing synaptogenesis in the adult, there are notable exceptions which include the olfactory and hippocampal regions of the nervous system. In the olfactory system the olfactory sensory neurons continually turn over and extend their axons into the olfactory bulb in a highly precise manner. Some preliminary data exists that suggests the presence of Wnt and Frizzled (Fz) family members in the primary olfactory …