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Full-Text Articles in Medicine and Health Sciences

Increased Risk Of Mental Illness Due To Epigenetic Alteration Of The Nr3c1 Gene After Early Life Adversity., Erin Mccue Apr 2022

Increased Risk Of Mental Illness Due To Epigenetic Alteration Of The Nr3c1 Gene After Early Life Adversity., Erin Mccue

Thinking Matters Symposium

Early life adversity (ELA), such as malnutrition, abuse, and economic disparity, is an issue commonly seen in adolescents, a group already facing increased risk for stress-related disorders. This review of current literature reveals that gestational stress exposure, as well as variations in maternal care during postnatal development, cause latent effects on the epigenome, specifically impacting the glucocorticoid receptors (GRs) encoded by the NR3C1 gene. GRs bind to glucocorticoids to regulate the body’s neuroendocrine stress response. However, in those with a history of ELA, the number of GRs is reduced, generating dysregulation within the hypothalamic-pituitary-adrenal (HPA) axis. Rodent studies are utilized …


Educator Wellbeing During Covid-19: Caregivers Vs. Non-Caregivers, Elizabeth Larsen, Judy Gagnon, Yana Davis, Nicole Hudson Apr 2021

Educator Wellbeing During Covid-19: Caregivers Vs. Non-Caregivers, Elizabeth Larsen, Judy Gagnon, Yana Davis, Nicole Hudson

Thinking Matters Symposium

The phenomenon of the COVID-19 pandemic has dramatically changed the format of public education, putting stress on the educational system and its teachers. This research study aims to understand the impact of COVID-19 on the role of teachers in Maine, specifically focusing on the added responsibility that parents may experience while simultaneously meeting professional obligations. Researchers posed the question: “What is the relationship between caregiving responsibilities and emotional wellbeing of teachers during the COVID-19 pandemic among public school teachers in Maine?” Participants from K-12 public schools around the state were recruited through direct contact or via building administrators who distributed …