Medicine and Health Sciences Commons^™

Gaip Interacting Protein C-Terminus Regulates Autophagy And Exosome Biogenesis Of Pancreatic Cancer Through Metabolic Pathways, Santanu Bhattacharya, Krishnendu Pal, Anil K. Sharma, Shamit K. Dutta, Julie S. Lau, Irene K. Yan, Enfeng Wang, Ahmed Elkhanany, Khalid M. Alkharfy, Arunik Sanyal, Tushar C. Patel, Suresh T. Chari, Mark R. Spaller, Debabrata Mukhopadhyay

Dartmouth Scholarship

GAIP interacting protein C terminus (GIPC) is known to play an important role in a variety of physiological and disease states. In the present study, we have identified a novel role for GIPC as a master regulator of autophagy and the exocytotic pathways in cancer. We show that depletion of GIPC-induced autophagy in pancreatic cancer cells, as evident from the upregulation of the autophagy marker LC3II. We further report that GIPC regulates cellular trafficking pathways by modulating the secretion, biogenesis, and molecular composition of exosomes. We also identified the involvement of GIPC on metabolic stress pathways regulating autophagy and microvesicular …

Top 10 Medicinal Plants And Their Groundbreaking Impact On Modern Medicine, Jordan N. Patterson, Joan Marie Lausier

Senior Honors Projects

This paper describes ten plants that having been groundbreaking drugs in the past century that were all derived from plants. I chose to do my project on this topic because of my family’s history with natural medicine. In 1999 my mother was diagnosed with Bile Duct cancer and the doctors gave her only a couple of weeks to live. The doctors recommended chemotherapy and radiation, but the results seemed negative for the situation. After some extensive research, my parents found St. Georges Medicinal Wellness Center located in the tiny village of Bad Aibling, Germany. This hospital along with offering traditional …

Mid-Atlantic Ethics Committee Newsletter, Fall 2014

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Safe Methods For Storage And Disposal Of Medicines, Timothy Cheum, Kejal Patel, Rodney Richmond

College of Pharmacy Faculty Research ​and Publications

No abstract provided.

Beta Cell Expansion Induced By Activin, Melissa Brown, Alan Schneyer, Ibrahim Osumanu

All Scholarly Works

No abstract provided.

The Baystate Frailty Study, John Budrow, Mihaela Stefan Md, Tara Lagu Md, Keith Spencer

All Scholarly Works

No abstract provided.

Publication Rates Of Presentations At Medical Meetings, Jonathan Housey

All Scholarly Works

No abstract provided.

Patient Beliefs Regarding Benefits Of Percutaneous Coronary Intervention In Chronic Stable Angina, Sarah Goff Md, Carla Lauture

All Scholarly Works

No abstract provided.

Herbal And Holistic Medicine In Latin America, William H. Lyle

Mahurin Honors College Capstone Experience/Thesis Projects

A variety of herbal and holistic remedies were used in pre-Columbian cultures, especially in Aztec and Incan cultures. Many different herbs were used to provide medical attention to patients directly, while other herbs were used to supplement shaman^[1] medicine, which was particularly common in Inca culture. While there is little scientific basis for shamanism, as a viable healing option in modern culture, most herbal remedies had active chemical ingredients that could be or are used today to treat similar symptoms, and, in some cases, are being applied in different scenarios as well. The methods of usage, active chemicals, and …

Critical Analysis Of The Kenyan Healthcare System And Models For Improvement, Justin Wellum

Mahurin Honors College Capstone Experience/Thesis Projects

Global epidemics such as malaria, tuberculosis, and HIV/AIDS plague developing countries in Africa. International aid has been given to these countries from public and private organizations in an effort to eradicate these health crises. My research focuses on Kenya as a model for assessing the current state of health care in these developing countries. The effectiveness of Kenya’s health care system was investigated at every level, including central, provincial, district, and rural, by visiting the country and performing specific research. Based on my research, I propose a model that I believe Kenya or any African developing country could adopt to …

Mid-Atlantic Ethics Committee Newsletter, Spring 2014

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Adaptation Of Semiautomated Circulating Tumor Cell (Ctc) Assays For Clinical And Preclinical Research Applications, Lori E. Lowes, Benjamin D. Hedley, Michael Keeney, Alison L. Allan

Anatomy and Cell Biology Publications

The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease stage is associated with the presence of circulating tumor cells (CTCs). These rare cells have been demonstrated to be of clinical significance in metastatic breast, prostate, and colorectal cancers. The current gold standard in clinical CTC detection and enumeration is the FDA-cleared CellSearch system (CSS). This manuscript outlines the standard protocol utilized by this platform as well as two additional adapted protocols that describe the detailed process of user-defined marker optimization for protein characterization of patient CTCs and a comparable protocol for CTC …

Spirituality In Nursing Practice, Regina Conway-Phillips

Nursing: School of Nursing Faculty Publications and Other Works

No abstract provided.

Treatment Of Asthma Exacerbations With The Human-Powered Nebuliser: A Randomised Parallel-Group Clinical Trial, M Therese Lysaught, Christopher J. Hallberg, Rene Antonio Najarro, Fausto Cea Gill, Clara Villatoro, Ana Celia Diaz De Uriarte, Lars E. Olson

Institute of Pastoral Studies: Faculty Publications and Other Works

Aims: The aim of this study was to compare a low-cost, human-powered nebuliser compressor with an electric nebuliser compressor for the treatment of mild to moderate asthma exacerbations in adults and children.

Methods: This was a non-blinded, parallel-group, equivalence study, with 110 subjects between 6 and 65 years of age, conducted in the emergency department of a district hospital in Ilopango, El Salvador. Participants were assigned by random allocation to receive a 2.5-mg dose of salbutamol from the experimental human-powered nebuliser or the electric nebuliser control. All assigned participants completed treatment and were included in analysis. The study was not …

Characterization Of A Human Powered Nebulizer Compressor For Resource Poor Settings, Christopher J. Hallberg, M Therese Lysaught, Christopher E. Zmudka, William K. Kopesky, Lars E. Olson

Institute of Pastoral Studies: Faculty Publications and Other Works

Respiratory disease accounts for three of the ten leading causes of death worldwide. Many of these diseases can be treated and diagnosed using a nebulizer. Nebulizers can also be used to safely and efficiently deliver vaccines. Unfortunately, commercially available nebulizers are not designed for use in regions of the world where lung disease is most prevalent: they are electricity-dependent, cost-prohibitive, and not built to be reliable in harsh operating conditions or under frequent use.

To overcome these limitations, the Human Powered Nebulizer compressor (HPN) was developed. The HPN does not require electricity; instead airflow is generated manually through a hand-crank …

Mid-Atlantic Ethics Committee Newsletter, Winter 2014

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Herbal And Holistic Medicine In Mexico And Peru, William H. Lyle

Student Research Conference Select Presentations

No abstract provided.

Noninvasive Assessment Of Cardiac Abnormalities In Experimental Autoimmune Myocarditis By Magnetic Resonance Microscopy Imaging In The Mouse, Chandirasegara Massilamany, Vahid Khalilzad-Sharghi, Arunakumar Gangaplara, David Steffen, Shadi F. Othman, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Myocarditis is an inflammation of the myocardium, but only ~10% of those affected show clinical manifestations of the disease. To study the immune events of myocardial injuries, various mouse models of myocarditis have been widely used. This study involved experimental autoimmune myocarditis (EAM) induced with cardiac myosin heavy chain (Myhc)-α 334-352 in A/J mice; the affected animals develop lymphocytic myocarditis but with no apparent clinical signs. In this model, the utility of magnetic resonance microscopy (MRM) as a non-invasive modality to determine the cardiac structural and functional changes in animals immunized with Myhc-α 334-352 is shown. EAM and healthy mice …