Medicine and Health Sciences Commons^™

Well-Born: Black Women And The Infertility Crisis No One Is Talking About, Kaara Baptiste

Capstones

Black women are twice as likely to experience infertility than white women, but are less likely to seek treatment or to have successful fertility results once treated. Despite this alarming number, this topic is not often discussed, even among the black community. My narrative piece t tells the story of a black woman confronting her infertility diagnosis and the role her race played in her fertility treatment, while exploring the role racism and sexuality have had in keeping this issue in the shadows.

Gaip Interacting Protein C-Terminus Regulates Autophagy And Exosome Biogenesis Of Pancreatic Cancer Through Metabolic Pathways, Santanu Bhattacharya, Krishnendu Pal, Anil K. Sharma, Shamit K. Dutta, Julie S. Lau, Irene K. Yan, Enfeng Wang, Ahmed Elkhanany, Khalid M. Alkharfy, Arunik Sanyal, Tushar C. Patel, Suresh T. Chari, Mark R. Spaller, Debabrata Mukhopadhyay

Dartmouth Scholarship

GAIP interacting protein C terminus (GIPC) is known to play an important role in a variety of physiological and disease states. In the present study, we have identified a novel role for GIPC as a master regulator of autophagy and the exocytotic pathways in cancer. We show that depletion of GIPC-induced autophagy in pancreatic cancer cells, as evident from the upregulation of the autophagy marker LC3II. We further report that GIPC regulates cellular trafficking pathways by modulating the secretion, biogenesis, and molecular composition of exosomes. We also identified the involvement of GIPC on metabolic stress pathways regulating autophagy and microvesicular …

The Green Staff Of Asclepius: Envisioning Sustainable Medicine, Jason Lee Fishel

Doctoral Dissertations

To make society sustainable our institutions must also become sustainable. As an institution, health care contributes to environmental degradation. While unsurprising, contributions to environmental degradation increase risk factors for disease and illness, effectively frustrating the goals of medicine. To find ways to make health care sustainable I begin by reviewing the literature on sustainability from within environmental ethics and two previous attempts at envisioning sustainable health care in order to learn what to include in a vision of sustainable health care. Then I examine problems specific to making medicine sustainable by investigating how sustainability might affect the principles of medicine. …

Top 10 Medicinal Plants And Their Groundbreaking Impact On Modern Medicine, Jordan N. Patterson, Joan Marie Lausier

Senior Honors Projects

This paper describes ten plants that having been groundbreaking drugs in the past century that were all derived from plants. I chose to do my project on this topic because of my family’s history with natural medicine. In 1999 my mother was diagnosed with Bile Duct cancer and the doctors gave her only a couple of weeks to live. The doctors recommended chemotherapy and radiation, but the results seemed negative for the situation. After some extensive research, my parents found St. Georges Medicinal Wellness Center located in the tiny village of Bad Aibling, Germany. This hospital along with offering traditional …

Mid-Atlantic Ethics Committee Newsletter, Fall 2014

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Medicine And Doctoring In Ancient Mesopotamia, Emily K. Teall

Grand Valley Journal of History

Medicine and pharmaceuticals in Mesopotamia during the span of c. 3000-1000 BCE were more sophisticated than many ancient and modern scholars from other cultures would concede. The limited historical evidence in the form of cuneiform texts and the complementary archaeological material allow for medical practice in this long time span to be examined as a whole. There were two dichotomous traditions of healing present in ancient Mesopotamia, one more therapeutic and one more religious; they were non-competitive and both considered reputable and essential. The therapeutic tradition is given a closer examination in order to provide a picture of how pharmaceutical …

Safe Methods For Storage And Disposal Of Medicines, Timothy Cheum, Kejal Patel, Rodney Richmond

College of Pharmacy Faculty Research ​and Publications

No abstract provided.

European Society For The History Of The Human Sciences (Eshhs), Conference 2014, Oulu (Finland), Paper: “Dangerous Passions. The Construction And Cultural And Social Impact Of The ‘Psychiatric’ Framework Of The Passions In France (1790-1830)”, July 22-25 (23th), 2014., Marco Solinas

Marco Solinas

Numerous excellent works have been written on the formation process of ‘psychiatry’ and its concomitant impact on society and culture at the end of the eighteenth century and in the first three decades of the nineteenth century, in particular with regard to France. From Gladys Swain to Dora Weiner, from Jacques Postel to Jan Goldstein, from Jackie Pigeaud to Juan Rigoli, the issue has been analysed in depth and from a variety of different perspectives. However, despite constantly and inevitably resurfacing in these studies, no particular attention has been paid to the passions and emotions drawn up by nascent psychiatry. …

Development And Validation Of The Ace Tool: Assessing Medical Trainees' Competency In Evidence Based Medicine, Dragan Ilic, Rusli Bin Nordin, Paul Glasziou, Julie Tilson, Elmer Villanueva

Paul Glasziou

Background: While a variety of instruments have been developed to assess knowledge and skills in evidence based medicine (EBM), few assess all aspects of EBM - including knowledge, skills attitudes and behaviour - or have been psychometrically evaluated. The aim of this study was to develop and validate an instrument that evaluates medical trainees' competency in EBM across knowledge, skills and attitude. Methods. The 'Assessing Competency in EBM' (ACE) tool was developed by the authors, with content and face validity assessed by expert opinion. A cross-sectional sample of 342 medical trainees representing 'novice', 'intermediate' and 'advanced' EBM trainees were recruited …

Burnout And Other Complex Challenges Causing Doctors To Become Patients In France And The United States, Cherry Chahal

Honors Theses

Everyday, people feel a calling to become a doctor for various reasons. These reasons include experiencing a disease or illness either through a family member or on one’s own, having a desire since childhood from hearing stories and wanting to help others, and perhaps wanting to propagate a family tradition and career. Out of all of the many reasons in the world, a desire to help others rises above the rest among to-be doctors. Thus, medical students and doctors dedicate their lives to learning about the human body in depth, well beyond what any introductory courses in biology will teach. …

Herbal And Holistic Medicine In Latin America, William H. Lyle

Mahurin Honors College Capstone Experience/Thesis Projects

A variety of herbal and holistic remedies were used in pre-Columbian cultures, especially in Aztec and Incan cultures. Many different herbs were used to provide medical attention to patients directly, while other herbs were used to supplement shaman^[1] medicine, which was particularly common in Inca culture. While there is little scientific basis for shamanism, as a viable healing option in modern culture, most herbal remedies had active chemical ingredients that could be or are used today to treat similar symptoms, and, in some cases, are being applied in different scenarios as well. The methods of usage, active chemicals, and …

Critical Analysis Of The Kenyan Healthcare System And Models For Improvement, Justin Wellum

Mahurin Honors College Capstone Experience/Thesis Projects

Global epidemics such as malaria, tuberculosis, and HIV/AIDS plague developing countries in Africa. International aid has been given to these countries from public and private organizations in an effort to eradicate these health crises. My research focuses on Kenya as a model for assessing the current state of health care in these developing countries. The effectiveness of Kenya’s health care system was investigated at every level, including central, provincial, district, and rural, by visiting the country and performing specific research. Based on my research, I propose a model that I believe Kenya or any African developing country could adopt to …

Which Lipid Measurement Should We Monitor? An Analysis Of The Lipid Study, Paul Glasziou, Les Irwig, Adrienne Kirby, Andrew Tonkin, R J. Simes

Paul Glasziou

Objectives: To evaluate the optimal lipid to measure in monitoring patients, we assessed three factors that influence the choice of monitoring tests: (1) clinical validity; (2) responsiveness to therapy changes and (3) the size of the long-term ‘signal-to-noise’ ratio. Design: Longitudinal analyses of repeated lipid measurement over 5 years. Setting: Subsidiary analysis of a Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study—a clinical trial in Australia, New Zealand and Finland. Participants: 9014 patients aged 31–75 years with previous acute coronary syndromes. Interventions: Patients were randomly assigned to 40 mg daily pravastatin or placebo. Primary and secondary outcome measures: We …

"What Happens In Romania..." Comes Back To The United States And Becomes A Quilt, Ashley Ehlers, Kaitlyn Torres

Senior Theses

Our senior thesis project is a quilt that chronicles our experiences on the Maymester trip to Romania through the Honors College, during which we were able to shadow surgeons in the Oncology Hospital and General Surgery III Hospital in Cluj-Napoca. In our quilt, we included some of the most common surgeries we saw while shadowing Romanian doctors: breast removal, gall bladder removal, appendix removal, removal of a section of the large intestine, and removal of the uterus. The final product of this quilt shows every level of the abdominal muscles and organs from the anterior skin to the kidneys.

To …

Wirelesseeg: Data Aquisition + Handheld Device, Michael Dylan Snowden, Madeline Threatt, Brent Mcferrin, David Platillero, Karsten Solies, Lindsey Hopf

Chancellor’s Honors Program Projects

No abstract provided.

Proceedings - Wright State University Boonshoft School Of Medicine Sixth Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Sixth Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 10, 2014.

Mid-Atlantic Ethics Committee Newsletter, Spring 2014

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

The Project Of The Physician: An Inquiry Into The Nature Of Medicine, Alexander X. Shea

Senior Theses and Projects

The telos of this project is twofold – in Part I, I will attempt to solidify the goal of the physician in medical practice, and in Part II, I will examine the specific ways by which the doctor can actualize that goal. In other words, the central questions are: 1) What is the goal of the physician? and 2) How is the physician to accomplish or actualize that goal?

Adaptation Of Semiautomated Circulating Tumor Cell (Ctc) Assays For Clinical And Preclinical Research Applications, Lori E. Lowes, Benjamin D. Hedley, Michael Keeney, Alison L. Allan

Anatomy and Cell Biology Publications

The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease stage is associated with the presence of circulating tumor cells (CTCs). These rare cells have been demonstrated to be of clinical significance in metastatic breast, prostate, and colorectal cancers. The current gold standard in clinical CTC detection and enumeration is the FDA-cleared CellSearch system (CSS). This manuscript outlines the standard protocol utilized by this platform as well as two additional adapted protocols that describe the detailed process of user-defined marker optimization for protein characterization of patient CTCs and a comparable protocol for CTC …

Spirituality In Nursing Practice, Regina Conway-Phillips

Nursing: School of Nursing Faculty Publications and Other Works

No abstract provided.

Treatment Of Asthma Exacerbations With The Human-Powered Nebuliser: A Randomised Parallel-Group Clinical Trial, M Therese Lysaught, Christopher J. Hallberg, Rene Antonio Najarro, Fausto Cea Gill, Clara Villatoro, Ana Celia Diaz De Uriarte, Lars E. Olson

Institute of Pastoral Studies: Faculty Publications and Other Works

Aims: The aim of this study was to compare a low-cost, human-powered nebuliser compressor with an electric nebuliser compressor for the treatment of mild to moderate asthma exacerbations in adults and children.

Methods: This was a non-blinded, parallel-group, equivalence study, with 110 subjects between 6 and 65 years of age, conducted in the emergency department of a district hospital in Ilopango, El Salvador. Participants were assigned by random allocation to receive a 2.5-mg dose of salbutamol from the experimental human-powered nebuliser or the electric nebuliser control. All assigned participants completed treatment and were included in analysis. The study was not …

Characterization Of A Human Powered Nebulizer Compressor For Resource Poor Settings, Christopher J. Hallberg, M Therese Lysaught, Christopher E. Zmudka, William K. Kopesky, Lars E. Olson

Institute of Pastoral Studies: Faculty Publications and Other Works

Respiratory disease accounts for three of the ten leading causes of death worldwide. Many of these diseases can be treated and diagnosed using a nebulizer. Nebulizers can also be used to safely and efficiently deliver vaccines. Unfortunately, commercially available nebulizers are not designed for use in regions of the world where lung disease is most prevalent: they are electricity-dependent, cost-prohibitive, and not built to be reliable in harsh operating conditions or under frequent use.

To overcome these limitations, the Human Powered Nebulizer compressor (HPN) was developed. The HPN does not require electricity; instead airflow is generated manually through a hand-crank …

Mid-Atlantic Ethics Committee Newsletter, Winter 2014

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Herbal And Holistic Medicine In Mexico And Peru, William H. Lyle

Student Research Conference Select Presentations

No abstract provided.

Noninvasive Assessment Of Cardiac Abnormalities In Experimental Autoimmune Myocarditis By Magnetic Resonance Microscopy Imaging In The Mouse, Chandirasegara Massilamany, Vahid Khalilzad-Sharghi, Arunakumar Gangaplara, David Steffen, Shadi F. Othman, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Myocarditis is an inflammation of the myocardium, but only ~10% of those affected show clinical manifestations of the disease. To study the immune events of myocardial injuries, various mouse models of myocarditis have been widely used. This study involved experimental autoimmune myocarditis (EAM) induced with cardiac myosin heavy chain (Myhc)-α 334-352 in A/J mice; the affected animals develop lymphocytic myocarditis but with no apparent clinical signs. In this model, the utility of magnetic resonance microscopy (MRM) as a non-invasive modality to determine the cardiac structural and functional changes in animals immunized with Myhc-α 334-352 is shown. EAM and healthy mice …

Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet

Undergraduate Research Posters

The World Health Organization has described the rise of antibiotic use as a “global heath security emergency” (who.int). With the growing concern about antibiotic resistant bacteria, there has been an increased interest in bacteriophages. Bacteriophages are high-specific viruses that only infect bacteria. The use of bacteriophages medicinally to treat bacteria is called phage therapy. Research in phage therapy gained momentum until the introduction of antibiotics. While the USA and other Western countries accepted antibiotics, the Soviet Union and their satellite nations still continued to research phages. Since the funding for research was supplied by the Soviet military, the results of …

Effects Of Some Of The Regional Turkish Fermented Foods And Medications On Respiratory Alcohol Levels, Cem Uysal, Mustafa Karapi̇rli̇, Mehmet Aki̇f İnanici

Turkish Journal of Medical Sciences

Alcohols are used in many areas like medicine and industry. They may be naturally found in some fruits and vegetables secondary to fermentation. According to the traffic law in Turkey, professional drivers are prohibited from driving while they are under the influence of alcohol; nonprofessional drivers are allowed to drive vehicles with a blood alcohol level of up to 50 mg/dL. The aim of this research is to determine whether or not consumed medicine or fermented, nonalcoholic beverages cause false positive results in breathalyzer tests. Materials and methods: In this research, we used nonalcoholic fermented foods and 6 medicines. After …