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Distinct Toll-Like Receptor Expression In Monocytes And T Cells In Chronic Hcv Infection, Angela Dolganiuc, Catherine Garcia, Karen Kodys, Gyongyi Szabo
Distinct Toll-Like Receptor Expression In Monocytes And T Cells In Chronic Hcv Infection, Angela Dolganiuc, Catherine Garcia, Karen Kodys, Gyongyi Szabo
Gyongyi Szabo
AIM: Hepatitis C virus often establishes chronic infections. Recent studies suggest that viral and bacterial infections are more common in HCV-infected patients compared to controls. Pathogens are recognized by Toll-like receptors (TLRs) to shape adaptive and innate immune responses.
METHODS: In this study, to assess the ability of HCV-infected host to recognize invading pathogens, we investigated Toll-like receptor expression in innate (monocytes) and adaptive (T cells) immune cells by real-time PCR.
RESULTS: We determined that RNA levels for TLRs 2, 6. 7, 8, 9 and 10 mRNA levels were upregulated in both monocytes and T cells in HCV-infected patients compared …