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Articles 1 - 30 of 50
Full-Text Articles in Medicine and Health Sciences
Carotid Intima Media Thickness In The Prediction Of St Elevation Myocardial Infarction, Ashish Kabra Md, Justin D. Roberts Do, Nitin Verma Md, Lori Neri Msn, Martin E. Matsumura Md
Carotid Intima Media Thickness In The Prediction Of St Elevation Myocardial Infarction, Ashish Kabra Md, Justin D. Roberts Do, Nitin Verma Md, Lori Neri Msn, Martin E. Matsumura Md
Department of Medicine
No abstract provided.
Proliferating Cell Nuclear Antigen Is Required For Loading Of The Smcx/Kmd5c Histone Demethylase Onto Chromatin., Zhihui Liang, Marc Diamond, Johanna A Smith, Matthias Schnell, René Daniel
Proliferating Cell Nuclear Antigen Is Required For Loading Of The Smcx/Kmd5c Histone Demethylase Onto Chromatin., Zhihui Liang, Marc Diamond, Johanna A Smith, Matthias Schnell, René Daniel
Department of Medicine Faculty Papers
UNLABELLED: ABSTRACT:
BACKGROUND: Histone methylation is regulated by a large number of histone methyltransferases and demethylases. The recently discovered SMCX/KMD5C demethylase has been shown to remove methyl residues from lysine 4 of histone H3 (H3K4), and constitutes an important component of the regulatory element-1-silencing transcription factor (REST) protein complex. However, little is known about the cellular mechanisms that control SMCX activity and intracellular trafficking.
RESULTS: In this study, we found that small interfering RNA-mediated knockdown of proliferating cell nuclear antigen (PCNA) resulted in the reduction of the chromatin-bound SMCX fraction. We identified a PCNA-interaction protein motif (PIP box) in the …
Coronary Ct Radiation Reduction - The Lehigh Valley Health Network Experience, Nitin Verma Md, Ashish N. Kabra Md, Justin D. Roberts Do, James A. Newcomb Md, Howard Rosenberg Md, Julie Gubernick, Robert Kricun Md, Matthew W. Martinez Md
Coronary Ct Radiation Reduction - The Lehigh Valley Health Network Experience, Nitin Verma Md, Ashish N. Kabra Md, Justin D. Roberts Do, James A. Newcomb Md, Howard Rosenberg Md, Julie Gubernick, Robert Kricun Md, Matthew W. Martinez Md
Department of Medicine
No abstract provided.
Whole-Exome Sequencing Of Dna From Peripheral Blood Mononuclear Cells (Pbmc) And Ebv-Transformed Lymphocytes From The Same Donor., Eric R Londin, Margaret A Keller, Michael R D'Andrea, Kathleen Delgrosso, Adam Ertel, Saul Surrey, Paolo Fortina
Whole-Exome Sequencing Of Dna From Peripheral Blood Mononuclear Cells (Pbmc) And Ebv-Transformed Lymphocytes From The Same Donor., Eric R Londin, Margaret A Keller, Michael R D'Andrea, Kathleen Delgrosso, Adam Ertel, Saul Surrey, Paolo Fortina
Kimmel Cancer Center Faculty Papers
BACKGROUND: The creation of lymphoblastoid cell lines (LCLs) through Epstein-Barr virus (EBV) transformation of B-lymphocytes can result in a valuable biomaterial for cell biology research and a renewable source of DNA. While LCLs have been used extensively in cellular and genetic studies, the process of cell transformation and expansion during culturing may introduce genomic changes that may impact their use and the interpretation of subsequent genetic findings.
RESULTS: We performed whole exome sequencing on a tetrad family using DNA derived from peripheral blood mononuclear cells (PBMCs) and LCLs from each individual. We generated over 4.7 GB of mappable sequence to …
Choosing Radial Vs. Femoral Cardiac Catheterization: Does Operator Seniority Matter? A Single Center Experience, Nitin Verma Md, Amit N. Nanavati Md, Justin D. Roberts Do, Nainesh C. Patel Md
Choosing Radial Vs. Femoral Cardiac Catheterization: Does Operator Seniority Matter? A Single Center Experience, Nitin Verma Md, Amit N. Nanavati Md, Justin D. Roberts Do, Nainesh C. Patel Md
Department of Medicine
No abstract provided.
Comparison Of Human Memory Cd8 T Cell Responses To Adenoviral Early And Late Proteins In Peripheral Blood And Lymphoid Tissue., Amita Joshi, Biwei Zhao, Cara Romanowski, David Rosen, Phyllis Flomenberg
Comparison Of Human Memory Cd8 T Cell Responses To Adenoviral Early And Late Proteins In Peripheral Blood And Lymphoid Tissue., Amita Joshi, Biwei Zhao, Cara Romanowski, David Rosen, Phyllis Flomenberg
Department of Microbiology and Immunology Faculty Papers
Treatment of invasive adenovirus (Ad) disease in hematopoietic stem cell transplant (SCT) recipients with capsid protein hexon-specific donor T cells is under investigation. We propose that cytotoxic T cells (CTLs) targeted to the late protein hexon may be inefficient in vivo because the early Ad protein E3-19K downregulates HLA class I antigens in infected cells. In this study, CD8+ T cells targeted to highly conserved HLA A2-restricted epitopes from the early regulatory protein DNA polymerase (P-977) and late protein hexon (H-892) were compared in peripheral blood (PB) and tonsils of naturally infected adults. In tonsils, epitope-specific pentamers detected a significantly …
The Interplay Between Nf-Kappab And E2f1 Coordinately Regulates Inflammation And Metabolism In Human Cardiac Cells., Xavier Palomer, David Álvarez-Guardia, Mercy M Davidson, Tung O Chan, Arthur M Feldman, Manuel Vázquez-Carrera
The Interplay Between Nf-Kappab And E2f1 Coordinately Regulates Inflammation And Metabolism In Human Cardiac Cells., Xavier Palomer, David Álvarez-Guardia, Mercy M Davidson, Tung O Chan, Arthur M Feldman, Manuel Vázquez-Carrera
Department of Medicine Faculty Papers
Pyruvate dehydrogenase kinase 4 (PDK4) inhibition by nuclear factor-κB (NF-κB) is related to a shift towards increased glycolysis during cardiac pathological processes such as cardiac hypertrophy and heart failure. The transcription factors estrogen-related receptor-α (ERRα) and peroxisome proliferator-activated receptor (PPAR) regulate PDK4 expression through the potent transcriptional coactivator PPARγ coactivator-1α (PGC-1α). NF-κB activation in AC16 cardiac cells inhibit ERRα and PPARβ/δ transcriptional activity, resulting in reduced PGC-1α and PDK4 expression, and an enhanced glucose oxidation rate. However, addition of the NF-κB inhibitor parthenolide to these cells prevents the downregulation of PDK4 expression but not ERRα and PPARβ/δ DNA binding activity, …
A Novel Approach For A New Era: Successful Integration Of Multidisciplinary, Hepatitis C Care Within An Established Hiv Primary Care Practice, Joseph L. Yozviak Do, Facp, Orlando J. Penaloza Md, Facp, Timothy J. Friel Md
A Novel Approach For A New Era: Successful Integration Of Multidisciplinary, Hepatitis C Care Within An Established Hiv Primary Care Practice, Joseph L. Yozviak Do, Facp, Orlando J. Penaloza Md, Facp, Timothy J. Friel Md
Department of Medicine
No abstract provided.
Open To The Public: Meeting The Nursing Challenge Of A Diverse America, Bonnie Wasilowsky Rn, Bspa-Hca, Cnrn
Open To The Public: Meeting The Nursing Challenge Of A Diverse America, Bonnie Wasilowsky Rn, Bspa-Hca, Cnrn
Patient Care Services / Nursing
No abstract provided.
Driving For Results: Building A Strong Local Aann Chapter To Assure Relevance In Neuroscience Nursing, Holly Tavianini Rn, Bsn, Mshsa, Cnrn, Jill Hinnershitz Msn, Rn
Driving For Results: Building A Strong Local Aann Chapter To Assure Relevance In Neuroscience Nursing, Holly Tavianini Rn, Bsn, Mshsa, Cnrn, Jill Hinnershitz Msn, Rn
Patient Care Services / Nursing
No abstract provided.
Posterior Reversible Encephalopathic Syndrome: Treating The Puzzling Syndrome Of Pres, Lorraine Valeriano Bsn, Rn, Cnrn
Posterior Reversible Encephalopathic Syndrome: Treating The Puzzling Syndrome Of Pres, Lorraine Valeriano Bsn, Rn, Cnrn
Patient Care Services / Nursing
No abstract provided.
Improving Outcomes For Hispanic Patients Undergoing Peginterferon/Ribavirin Therapy For Chronic Hepatitis C In An Internist-Led, Multidisciplinary, Multi-Cultural Practice: A Unique Application Of The Medical, Joseph L. Yozviak Do, Facp, Orlando J. Penaloza Md, Facp, Judith A. Knoop
Improving Outcomes For Hispanic Patients Undergoing Peginterferon/Ribavirin Therapy For Chronic Hepatitis C In An Internist-Led, Multidisciplinary, Multi-Cultural Practice: A Unique Application Of The Medical, Joseph L. Yozviak Do, Facp, Orlando J. Penaloza Md, Facp, Judith A. Knoop
Department of Medicine
No abstract provided.
Using Lean Principals To Improve Patient Flow, Keith Weinhold Mha, Fache, Eliot L. Friedman Md, Darlene Matthias Rn, Ms, Ocn, Mary R. Greenberg, Amy E. Levan Rn, Bsn, Ocn, Jill Korn Rn, Bsn, Ocn, Melissa Kratz Rn, Msn, Aocn, Mandy Melocheck Rn, Msn, Ocn, Cindy J. Fenton Rn, Ocn, Janine Barnaby Rph, Bcop, Jeanne Kenna Rn, Ocn, Jennifer Mesker Pharmad, Kyle Sabatino Rn, Msn, Aocn, Lori Turnbach, Maura Price Rn, Bsn, Ocn, Pamela Tobias Ms, Rhia, Patricia Shearburn Rn, Msn, Aocn, Ramona E. Chase Crnp, Stephanie Thomas, Pamela Repetz, Barbara Versage Rn, Mba, Cphq
Using Lean Principals To Improve Patient Flow, Keith Weinhold Mha, Fache, Eliot L. Friedman Md, Darlene Matthias Rn, Ms, Ocn, Mary R. Greenberg, Amy E. Levan Rn, Bsn, Ocn, Jill Korn Rn, Bsn, Ocn, Melissa Kratz Rn, Msn, Aocn, Mandy Melocheck Rn, Msn, Ocn, Cindy J. Fenton Rn, Ocn, Janine Barnaby Rph, Bcop, Jeanne Kenna Rn, Ocn, Jennifer Mesker Pharmad, Kyle Sabatino Rn, Msn, Aocn, Lori Turnbach, Maura Price Rn, Bsn, Ocn, Pamela Tobias Ms, Rhia, Patricia Shearburn Rn, Msn, Aocn, Ramona E. Chase Crnp, Stephanie Thomas, Pamela Repetz, Barbara Versage Rn, Mba, Cphq
Administration & Leadership
No abstract provided.
Giant Cell Arteritis Presenting With Bilateral Axillary Artery Occlusions, Vertebral Artery Stenosis And Left Internal Mammary Artery Graft Stenosis, Rashmi Sharma Md, J Patrick Kleaveland Md, Marie S. O’Brien Do
Giant Cell Arteritis Presenting With Bilateral Axillary Artery Occlusions, Vertebral Artery Stenosis And Left Internal Mammary Artery Graft Stenosis, Rashmi Sharma Md, J Patrick Kleaveland Md, Marie S. O’Brien Do
Department of Medicine
No abstract provided.
Using Teach Back To Reduce Readmission Rates In Hospitalized Heart Failure Patients, Michael Pistoria Do, Facp, Sfhm, Debra Peter Msn, Rn, Bc, Cmsrn, Paula Robinson Msn, Rn, Bc, Kim Jordan Mha, Bsn, Rn, Ne-Bc, Susan Lawrence Ms, Cmac
Using Teach Back To Reduce Readmission Rates In Hospitalized Heart Failure Patients, Michael Pistoria Do, Facp, Sfhm, Debra Peter Msn, Rn, Bc, Cmsrn, Paula Robinson Msn, Rn, Bc, Kim Jordan Mha, Bsn, Rn, Ne-Bc, Susan Lawrence Ms, Cmac
Department of Medicine
No abstract provided.
Neurological And Cardiovascular Outcomes After Cardiac Arrest At Six Regional Interventional Cardiology Centers In The United States 2007-2011, David B. Seder Md, Nainesh Patel Md, John Mcpherson Md, Paul W. Mcmullan Md, Karl B. Kern Md, Barbara Unger Rn, J Browning, Sudip Nanda Md, Facp, Melkon Hacobian Md, Michael B. Kelley Md, Niklas Nielsen Md, Phd, Michael R. Mooney Md
Neurological And Cardiovascular Outcomes After Cardiac Arrest At Six Regional Interventional Cardiology Centers In The United States 2007-2011, David B. Seder Md, Nainesh Patel Md, John Mcpherson Md, Paul W. Mcmullan Md, Karl B. Kern Md, Barbara Unger Rn, J Browning, Sudip Nanda Md, Facp, Melkon Hacobian Md, Michael B. Kelley Md, Niklas Nielsen Md, Phd, Michael R. Mooney Md
Department of Medicine
No abstract provided.
Post-Resuscitation Care Practices Following Cardiac Arrest At Six Regional Interventional Cardiology Centers In The United States 2007-2011, David B. Seder Md, Nainesh Patel Md, John A. Mcpherson Md, Paul W. Mcmullan Md, Karl B. Kern Md, Barbara T. Unger Rn, J Browning, Sudip Nanda Md, Facp, Melkon Hacobian Md, Michael B. Kelley Md, Niklas Nielsen Md, Phd, Michael R. Mooney Md
Post-Resuscitation Care Practices Following Cardiac Arrest At Six Regional Interventional Cardiology Centers In The United States 2007-2011, David B. Seder Md, Nainesh Patel Md, John A. Mcpherson Md, Paul W. Mcmullan Md, Karl B. Kern Md, Barbara T. Unger Rn, J Browning, Sudip Nanda Md, Facp, Melkon Hacobian Md, Michael B. Kelley Md, Niklas Nielsen Md, Phd, Michael R. Mooney Md
Department of Medicine
No abstract provided.
The Teaching Leader Series: Interprofessional Faculty Development, Amy B. Smith Phd, James P. Orlando Edd, Elissa Foster Phd, Jaan Naktin Md, Cynthia A. Cappel Msn, Rn-Bc1, Alexander J. Lemheney Med, Frazier T. Stevenson Md
The Teaching Leader Series: Interprofessional Faculty Development, Amy B. Smith Phd, James P. Orlando Edd, Elissa Foster Phd, Jaan Naktin Md, Cynthia A. Cappel Msn, Rn-Bc1, Alexander J. Lemheney Med, Frazier T. Stevenson Md
Department of Education
No abstract provided.
Dashboards Drive Direction, Susan L. Lawrence Ms, Cmac, Krista J. Casey Mba
Dashboards Drive Direction, Susan L. Lawrence Ms, Cmac, Krista J. Casey Mba
Administration & Leadership
No abstract provided.
Oral Fixed Drug Eruption Secondary To Isoniazid, Tanya Ermolovich Do, Tatyana Groysman Do
Oral Fixed Drug Eruption Secondary To Isoniazid, Tanya Ermolovich Do, Tatyana Groysman Do
Department of Medicine
No abstract provided.
Pyroglutamic Acidosis: A Rare And Underdiagnosed Cause Of High Anion Gap Metabolic Acidosis, Brigid Hallinan Do, Tina M. Casey Do, Matthew Mccambridge Md
Pyroglutamic Acidosis: A Rare And Underdiagnosed Cause Of High Anion Gap Metabolic Acidosis, Brigid Hallinan Do, Tina M. Casey Do, Matthew Mccambridge Md
Department of Medicine
No abstract provided.
Uncommon Treatment Of Mononeuritis Multiplex In A 37-Year-Old Male, Nicole Daver Do, Ankush Sharma Md, Manjeera Cherukuri Md
Uncommon Treatment Of Mononeuritis Multiplex In A 37-Year-Old Male, Nicole Daver Do, Ankush Sharma Md, Manjeera Cherukuri Md
Department of Medicine
No abstract provided.
Unusual Case Of Thrombotic Thrombocytopenic Purpura (Ttp) In Capnocytophaga Canimorsus Bacteremia, Nicole W. Tong Do
Unusual Case Of Thrombotic Thrombocytopenic Purpura (Ttp) In Capnocytophaga Canimorsus Bacteremia, Nicole W. Tong Do
Department of Medicine
No abstract provided.
From The Home To The Hospital: The New Bath Salts, Jeanne Zukas Do, Matthew D. Cook Do
From The Home To The Hospital: The New Bath Salts, Jeanne Zukas Do, Matthew D. Cook Do
Department of Medicine
No abstract provided.
Esta En Sus Manos! It’S In Your Hands!, Lenore Mcgonigle Med, Vanessa Soto, Hannabi Torres, Heiwon Chung Md, Facs, Nadesda Mack Rn, Bsn, Mba, Ocn, Renae Stonehouse Rt, (R), (M), Maryellen Shiels Bs
Esta En Sus Manos! It’S In Your Hands!, Lenore Mcgonigle Med, Vanessa Soto, Hannabi Torres, Heiwon Chung Md, Facs, Nadesda Mack Rn, Bsn, Mba, Ocn, Renae Stonehouse Rt, (R), (M), Maryellen Shiels Bs
Department of Medicine
No abstract provided.
Improving Symptoms Of Stress Urinary Incontinence For Patients With Dyspareunia Utilizing Physical Therapy: A Case Report, Karen Snowden Pt, Dpt, Lauren Garges Pt, Ms
Improving Symptoms Of Stress Urinary Incontinence For Patients With Dyspareunia Utilizing Physical Therapy: A Case Report, Karen Snowden Pt, Dpt, Lauren Garges Pt, Ms
Department of Medicine
No abstract provided.
Improving The Quality Of Information Sent To Primary Care Physicians For Patients Discharged From Nursing Facilities, Catherine M. Glew Bm, Bs, Cmd, Anne M. Yawman Md
Improving The Quality Of Information Sent To Primary Care Physicians For Patients Discharged From Nursing Facilities, Catherine M. Glew Bm, Bs, Cmd, Anne M. Yawman Md
Department of Medicine
No abstract provided.
Neo-Adjuvant Chemotherapy And Radiation Therapy In Patients With Stage Iiia (N2) Non-Small Cell Lung Cancer (Nsclc): A Retrospective Analysis With Lessons Learned, Eliot L. Friedman Md, Michael F. Szwerc Md, Charles Andrews Md, Robert Kruklitis Md, Kathleen A. Leies, Ferdy Santiago
Neo-Adjuvant Chemotherapy And Radiation Therapy In Patients With Stage Iiia (N2) Non-Small Cell Lung Cancer (Nsclc): A Retrospective Analysis With Lessons Learned, Eliot L. Friedman Md, Michael F. Szwerc Md, Charles Andrews Md, Robert Kruklitis Md, Kathleen A. Leies, Ferdy Santiago
Department of Medicine
No abstract provided.
Safe Patient Handling And Movement Programs:Implications For Occupational Therapy, Holly Ehrenfried Otr/L, Cht
Safe Patient Handling And Movement Programs:Implications For Occupational Therapy, Holly Ehrenfried Otr/L, Cht
Department of Medicine
No abstract provided.
Risk Factors Affecting Surgical Outcomes In Patients Undergoing Hypothermic Circulatory Arrest During Aortic Surgeries: A 10-Year Study, Bree Ann Young, James K. Wu, Martin E. Matsumura Md, Sanjay M. Mehta Md, Theodore G. Phillips Md, Michael F. Szwerc Md, Gary W. Szydlowski Md, Raymond L. Singer Md
Risk Factors Affecting Surgical Outcomes In Patients Undergoing Hypothermic Circulatory Arrest During Aortic Surgeries: A 10-Year Study, Bree Ann Young, James K. Wu, Martin E. Matsumura Md, Sanjay M. Mehta Md, Theodore G. Phillips Md, Michael F. Szwerc Md, Gary W. Szydlowski Md, Raymond L. Singer Md
Department of Medicine
No abstract provided.