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Full-Text Articles in Medicine and Health Sciences
Australian Women's Perceptions Of Breast Cancer Risk Factors And The Risk Of Developing Breast Cancer, Sandra C. Jones, Christopher A. Magee, Lance R. Barrie, Donald C. Iverson, Parri Gregory, Emma L. Hanks, Anne E. Nelson, Caroline L. Nehill, Helen M. Zorbas
Australian Women's Perceptions Of Breast Cancer Risk Factors And The Risk Of Developing Breast Cancer, Sandra C. Jones, Christopher A. Magee, Lance R. Barrie, Donald C. Iverson, Parri Gregory, Emma L. Hanks, Anne E. Nelson, Caroline L. Nehill, Helen M. Zorbas
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background Numerous studies have shown that the majority of women overestimate both their own risk and the populations’ risk of developing breast cancer. A number of factors have been found to correlate with perceived risk. Methods This paper reports on a telephone survey of a nationally representative sample of approximately 3,000 Australian women aged 30 to 69 years, conducted in 2007, and compares the findings with those of a similar survey conducted in 2003. Results There was a clear tendency for respondents to overestimate the proportion of women who will develop breast cancer during their lifetime. Approximately half the respondents …
Does Presentation Make A Difference To Risk Perception: Testing Different Formats For Communication Of Cancer Risks, Sandra C. Jones
Does Presentation Make A Difference To Risk Perception: Testing Different Formats For Communication Of Cancer Risks, Sandra C. Jones
Faculty of Health and Behavioural Sciences - Papers (Archive)
Evidence suggests that the presentation format of risk information can affect people’s perceptions of risk and influence health-related decisions. In these studies we investigated the impact of four different risk presentation formats: standard presentation, risk ladder, different base rates and visual representations on women’s perceptions of developing breast cancer of lymphoma. We found that the different presentations had virtually no impact on the participant’s risk estimates. Only in the second study relating to risk perceptions for lymphoma was there a significant difference between conditions for estimated 10-year-risk, with those in the ladder present condition reporting a lower estimated risk. The …
Multiple Myeloma; Clinical Update On A Rare And Treatable Cancer, Moira Stephens
Multiple Myeloma; Clinical Update On A Rare And Treatable Cancer, Moira Stephens
Faculty of Health and Behavioural Sciences - Papers (Archive)
Multiple myeloma is a rare cancer, contributing 1% of cancers and 15% of haematological malignancies. Myeloma is an incurable, yet increasingly treatable cancer with people often living in a chronic (controlled) state of relapse, i.e. living with a low level of disease for many years. Survival with myeloma varies from a few months to decades. Nurses play a valuable role in caring for people with myeloma and with their specialist knowledge of the pathophysiology of myeloma and the effects of treatment, together with their therapeutic relationship with the patient and the family, are in an important position to influence care …
Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie
Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie
Faculty of Health and Behavioural Sciences - Papers (Archive)
In search of natural bioactive microbial compounds with adjuvant properties, we have previously showed that the polysaccharopeptide (PSP), isolated from Chinese medicinal mushroom Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. The present study aimed to investigate whether the synergism of mechanisms of PSP with certain chemotherapeutic drugs also applies to human breast cancer. PSP treatment enhanced the cytotoxicity of doxorubicin (Doxo), etoposide (VP-16) but not cytarabine (Ara-C). Bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometry analysis estimated a longer DNA synthesis time (Ts) for the PSP treated …
Depression And Quality Of Life In Cancer Survivors: Is There A Relationship With Physical Activity?, Nancy Humpel, Donald Iverson
Depression And Quality Of Life In Cancer Survivors: Is There A Relationship With Physical Activity?, Nancy Humpel, Donald Iverson
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background Evidence is growing on the benefit of physical activity to improve well-being following a cancer diagnosis. This study examined changes in physical activity from pre to post diagnosis and explored this relationship with quality of life and depression. Methods Participants were recruited by posters and by letter of invitation. The questionnaire was completed by 59 prostate and 32 breast cancer survivors. Results Physical activity decreased by 72 minutes per week from pre to post diagnosis, although 20.9% reported having increased activity post diagnosis. Over 30% were considered depressed. Breast cancer participants who increased physical activity post diagnosis reported higher …
Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson
Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson
Faculty of Health and Behavioural Sciences - Papers (Archive)
INTRODUCTION: The regulation of extracellular proteolytic activity via the plasminogen activation system is complex, involving numerous activators, inhibitors and receptors. Previous studies on monocytic and colon cell lines suggest that plasmin pre treatment can increase plasminogen binding, allowing the active enzyme to generate binding sites for its precursor. Other studies have shown the importance of pre formed receptors such as annexin II heterotetramer. However, few studies have utilised techniques which exclusively characterise cell surface events and these mechanisms have not been investigated at the breast cancer cell surface. METHODS: We have studied plasminogen binding to MCF 7 in which uPAR …
Counterfactual Thinking In Response To Hypothetical Breast Cancer Scenarios: A Pilot Study, Amy Y. Chan, Sandra C. Jones, Karen T. Rich
Counterfactual Thinking In Response To Hypothetical Breast Cancer Scenarios: A Pilot Study, Amy Y. Chan, Sandra C. Jones, Karen T. Rich
Faculty of Health and Behavioural Sciences - Papers (Archive)
This paper examined womens counterfactualthoughts in response to hypothetical scenarios aboutearly versus late breast cancer diagnoses.Womenaged 50 and over (N=29) read hypotheticalscenarios about the experience of fictitious womenof mammography screening age and completedcounterfactual statements from the protagonistsperspective.In two scenarios, the protagonist failedto attend mammography screening regularly andwas diagnosed with advanced breast cancer; thethird scenario depicted a woman who hadmammograms biennially and received an early-stagebreast cancer diagnosis.Consistent with pastliterature on counterfactual thinking, participantsgenerated exclusively upward counterfactuals fromthe two late-diagnosis scenarios, and predominantlydownward counterfactuals from the early-diagnosisscenario.Furthermore, participants primarilyfocussed on what the protagonist could personallyhave done differently to lead to a differentoutcome.Hence …
A Structural Basis For Differential Cell Signalling By Pai-1 And Pai-2 In Breast Cancer Cells, Marie Ranson, David Croucher, Darren Saunders, Gillian E. Stillfried
A Structural Basis For Differential Cell Signalling By Pai-1 And Pai-2 In Breast Cancer Cells, Marie Ranson, David Croucher, Darren Saunders, Gillian E. Stillfried
Faculty of Health and Behavioural Sciences - Papers (Archive)
PAI-1 and PAI-2 (plasminogen-activator inibitor types 1 and 2) are inhibitors of cell surface uPA (urokinase plasminogen activator). However, tumour expression of PAI-1 and PAI-2 correlates with poor compared with good patient prognosis in breast cancer respectively. This biological divergence may be related to additional functional roles of PAI-1. For example, the inhibition of uPA by PAI-1 reveals a cryptic high-affinity site within the PAI-1 moiety for the VLDLr (very-low-density-lipoprotein receptor), which sustains cell signalling events initiated by binding of uPA to its receptor. These interactions and subsequent signalling events promote proliferation of breast cancer cells. Biochemical and structural analyses …