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Full-Text Articles in Medicine and Health Sciences
Effects Of Ef-24 And Cisplatin On Cancer, Renal, And Auditory Cells, Denis Hodzic
Effects Of Ef-24 And Cisplatin On Cancer, Renal, And Auditory Cells, Denis Hodzic
Masters Theses & Specialist Projects
Cisplatin is a chemotherapy drug effective against several forms of cancer, but can also cause serious side-effects, including nephrotoxicity and ototoxicity. Curcumin, a natural plant compound, can increase cisplatin’s anti-cancer activity and counteract cisplatin’s deleterious effect on the auditory and renal systems. Unfortunately, curcumin exhibits poor bioavailability, which has promoted interest in the development of synthetic curcumin analogs (curcuminoids) that are soluble, target cancer, and do not cause side effects. This study investigated whether the curcuminoid (3E,5E)-3,5-bis[(2-fluorophenyl) methylene]-4-piperidinone (EF-24) increases the anti-cancer effects of cisplatin against a human ovarian cancer cell line (A2780) and its cisplatin-resistant counterpart (A2780cis), while preventing …
Determining Efficacy Of Anti-Cancer Drug From Detection In Plasma Using The Hplc Method, Nili Modi
Determining Efficacy Of Anti-Cancer Drug From Detection In Plasma Using The Hplc Method, Nili Modi
BIO4950: Internship in Biology
Extraction of anti-cancer drug in plasma from in vivo organism models were studied to examine and differentiate the different methods. Along with extraction, detection of the amount and the retention period of the anti- cancer drug in plasma in the test subjects were focused on to analyze the ways of the HPLC method. The HPLC (High Performance Liquid Chromatography) method is the most frequently used method for detection in many labs due to its ability to be programed quick with minimal training and to ensure accurate results. Using animal models to detect plasma drug levels in pre-clinical trials is valuable …
Analyzing Brain Sample Via Hplc Method, Neethu Mathew
Analyzing Brain Sample Via Hplc Method, Neethu Mathew
BIO4950: Internship in Biology
This paper aims to investigate the principle methodology behind extraction and detection of an anti-cancer drug from brain samples via the high performance liquid chromatography (HPLC) method. In order to assess the efficiency of the methodology carried out in the Rumbaugh-Goodwin Institute of Cancer Research (RGI), numerous peer-reviewed journals and articles were analyzed over the duration of this internship. They were filtered on the basis of inclusion of keywords, date written, peer-reviewed credibility, and similarity to RGI’s research. The literature that has been chosen to be reviewed includes studies that present similar methodologies or test drugs with similar functions. From …