Medicine and Health Sciences Commons^™

Immune Checkpoint Inhibitor Therapy For Advanced Cutaneous Squamous Cell Carcinoma In Australia: A Retrospective Real World Cohort Study, Luke S. Mclean, Annette M. Lim, Mathias Bressel, Jenny Lee, Rahul Ladwa, Alexander D. Guminski, Brett Hughes, Samantha Bowyer, Karen Briscoe, Samuel Harris, Craig Kukard, Rob Zielinski, Muhammad Alamgeer, Matteo Carlino, Jeremy Mo, John J. Park, Muhammad A. Khattak, Fiona Day, Danny Rischin

Research outputs 2022 to 2026

Objectives: To review the outcomes of immune checkpoint inhibitor (ICI) treatment of advanced cutaneous squamous cell carcinoma (CSCC) outside clinical trials. Study design: Retrospective observational study; review of patient records in fifteen Australian institutions. Setting, participants: All Australian adults with locally advanced or metastatic CSCC not amenable to curative surgery or radiotherapy treated with ICIs, 5 May 2017 – 23 May 2022, through a cemiplimab compassionate access scheme (Therapeutic Goods Administration Special Access Scheme) or who personally covered the cost of pembrolizumab prior to the start of the access scheme. Main outcome measures: Best overall response rate (ORR) according to …

Nutrition, Body Composition And Physical Activity In Malignant Pleural Disease: Associations With Patient Outcomes And Response To An Exercise Intervention, Emily Jeffery

Theses: Doctorates and Masters

Background: Patients with malignant pleural disease (MPD) have advanced cancer and high symptom burden. Goals of patient care are to optimise health-related quality-of-life (HR-QoL) and participation in daily physical activities. Supportive care interventions such as nutrition and exercise could offer benefit to patients. However, there is a lack of information on the prevalence of low muscle mass (i.e., pre-sarcopenia), malnutrition, inactivity and poor physical functioning in patients with MPD. Additionally, little is known about the factors associated with development of pre-sarcopenia and malnutrition or their associations with patient outcomes.

Purpose: The objectives were to: 1) characterise physical activity levels and …

Autoantibody Production In Cancer—The Humoral Immune Response Toward Autologous Antigens In Cancer Patients, Pauline Zaenker, Elin Solomonovna Gray, Melanie Ruth Ziman

Research outputs 2014 to 2021

A link between autoimmune responses and cancer via autoantibodies was first described in the 1950s. Since, autoantibodies have been studied for their potential use as cancer biomarkers, however the exact causes of their production remain to be elucidated. This review summarizes current theories of the causes of autoantibody production in cancer, namely:

1) defects in tolerance and inflammation,

2) changes in protein expression levels,

3) altered protein structure, and

4) cellular death mechanisms.

We also highlight the need for further research into this field to improve our understanding of autoantibodies as biomarkers for cancer development and progression.