Medicine and Health Sciences Commons^™

Biomarker Metabolite Discovery For Pancreatic Cancer Using Machine Learning, Immanuelle Kezia, Linda Erlina, Aryo Tedjo, Fadilah Fadilah

Indonesian Journal of Medical Chemistry and Bioinformatics

Pancreatic cancer is one of the deadliest cancers in the world. This cancer is caused by multiple factors and mostly detected at late stadium. Biomarker is a marker that can identify some diseases very specific. For pancreatic cancer, biomarker has been recognized using blood sample known as liquid biopsy, breath, pancreatic secret, and tumor marker CA19-9. Those biomarkers are invasive, so we want to identify the disease using a very convenient method. Metabolite is product from cell metabolism. Metabolites can become a biomarker especially from difficult diseases. In this paper, we want to find biomarker from metabolite using machine learning …

A High Glucose Concentration Is Well Tolerated By Colorectal Adenocarcinoma And Melanoma Cells But Toxic To Normal Human Gingival Fibroblast: Results Of An In Vitro Investigation, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa

Makara Journal of Health Research

Background: Glucose is associated with weight gain, which increases the risk of cancer. There is insufficient information on the effects of high glucose concentrations on cell lines. This study evaluated the viability patterns of human cancer and normal cell lines treated with glucose.

Methods: Human gingival fibroblast (hGF), colorectal adenocarcinoma (HT29), and skin malignant melanoma (A375) cell lines were cultured and treated with additional glucose in three respective concentrations: 1 mg/ml, 5 mg/ml, and 10 mg/ml. Then, cell viability was measured using an MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide)-assay. The data were analyzed using the Statistical Package for the Social Sciences …