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2024

Pediatrics

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Full-Text Articles in Medicine and Health Sciences

The Effects Of Music Therapy On Pediatric Patients With Congenital Heart Defects In The Pre And Postoperative Setting, Janelle Marie Choy Dec 2024

The Effects Of Music Therapy On Pediatric Patients With Congenital Heart Defects In The Pre And Postoperative Setting, Janelle Marie Choy

Nursing | Student Research Posters

Congenital heart defects is a prominent medical occurrence especially in pediatrics. These defects often require surgeries and extensive treatment plans. These treatment plans often include invasive surgeries and extensive treatment plans which can require long recovery times along with potential surgical complications. This study aims to evaluate the effectiveness of music therapy on pediatric patients with congenital heart defects in the pre and postoperative setting and how music therapy can be implemented in treatment plans to yield effective recovery results for these patients. This research is significant as elevated vital signs and preoperative anxiety are associated with an increased need …


Educating Pediatric Registered Nurses On The Administration Of Prolonged Intravenous Antibiotics, Kasandra Rezler May 2024

Educating Pediatric Registered Nurses On The Administration Of Prolonged Intravenous Antibiotics, Kasandra Rezler

Master's Projects and Capstones

Abstract

Problem According to Children’s Hospital A's incident reporting system, 50% of problems related to prolonged intravenous antibiotics were classified as administration issues. When mistakes are made in this process, the antibiotic is then delivered at the wrong rate or the wrong time, which is problematic. Additionally, findings from a needs assessment survey highlight a critical need for targeted interventions, such as an educational video, to reduce administration errors associated with prolonged IV antibiotics. Context Within Children’s Hospital A, the microsystems targeted by this quality improvement project consist of inpatient pediatric patient care units (PCU) 300, 360, and 400. Children’s …


A Peer-Mediated Art Program For Secondary Education Students: An Occupation Based Approach, Kjersten B. Sievers May 2024

A Peer-Mediated Art Program For Secondary Education Students: An Occupation Based Approach, Kjersten B. Sievers

Occupational Therapy Capstone Presentations

The purpose of this 14-week capstone project was to explore the impact of a peer-mediated art program on the social and occupational experiences of students with disabilities. This program was designed and implemented to promote inclusion of students with disabilities by providing an opportunity to interact with typically developing peers within their school-context. The 7-week peer-mediated art program was embedded into a startup peer-program at a high school. A total of 10 participants (4 from special education) were recruited to complete the study. Students met for three 45-minute sessions and one 90-minute session each week as part of the program’s …


Addressing Air Quality Mitigation As A Key Factor In Asthma Management And Prevention, Julia Buckles, Jewel Radford May 2024

Addressing Air Quality Mitigation As A Key Factor In Asthma Management And Prevention, Julia Buckles, Jewel Radford

Doctor of Nursing Practice Projects

Asthma is the most prevalent disease in childhood and disproportionately affects African American (AA) populations in terms of prevalence and frequency of exacerbations. Air quality and environmental factors are strongly associated with the diagnosis and management of asthma and AA children are more likely to live in areas with poor air quality. An air quality flag program was implemented in a daycare located in a county with a predominantly AA population with a high prevalence of asthma diagnoses. The goal of the intervention was to increase staff awareness of air quality and the impact it can have on asthma diagnosis …


Cytogenetic Findings And Maternal Age In Patients With Down Syndrome In A Pediatric Referral Hospital From Peru, Yesica Llimpe Mitma De Barrón, Maribel Susana Ccoyllo Álvarez, Milana Trubnykova, Rocío Margarita González Moreno May 2024

Cytogenetic Findings And Maternal Age In Patients With Down Syndrome In A Pediatric Referral Hospital From Peru, Yesica Llimpe Mitma De Barrón, Maribel Susana Ccoyllo Álvarez, Milana Trubnykova, Rocío Margarita González Moreno

Revista de la Facultad de Medicina Humana

Introduction: Down syndrome is a congenital disorder caused by a total or partial trisomy of chromosome 21 and is considered the most common genetic cause of congenital malformations and intellectual disability. The objective of this study was to describe the cytogenetic alterations of patients with Down syndrome and their relationship with maternal age. Methods: Cross-sectional, descriptive-analytical study. 436 patients with Down syndrome admitted to the Instituto Nacional de Salud del Niño during the 2017-2019 period were included. The variables analyzed were: cytogenetic diagnosis and maternal age. Results: It was found that 99,3% (n=433) of patients presented some type of cytogenetic …


How Psychological And Nonpharmacological Treatment Modalities Reduce The Disease Burden Of Amplified Musculoskeletal Pain Syndromes In Pediatrics, Aalia Narvel, Sabrina Gmuca May 2024

How Psychological And Nonpharmacological Treatment Modalities Reduce The Disease Burden Of Amplified Musculoskeletal Pain Syndromes In Pediatrics, Aalia Narvel, Sabrina Gmuca

Rowan-Virtua Research Day

The prevalence of pediatric chronic musculoskeletal pain ranges from 8.5% to 40%.1 This literature review examined the treatment of amplified musculoskeletal pain syndrome (AMPS), which is a general term that represents a spectrum of pain disorders for patients who may not satisfy specific diagnostic criteria.2 Specifically, sources were analyzed to compare the efficacy of individual components in the nonpharmacological, interdisciplinary treatment of AMPS against pain medications. These components included cognitive behavioral psychotherapy (CBT), physical therapy (PT), as well as occupational therapy (OT). There is limited information that assesses these components individually, but there is ample evidence that when …


Standardization Of Discharge Instructions For Mild Traumatic Brain Injury/Concussion In Children Presenting To Ed: A Qi Project, Niralee K. Rana, Nicole Gerber Md, Michael Alfonzo Md, Snezana Osorio Md, Deborah Levine Md May 2024

Standardization Of Discharge Instructions For Mild Traumatic Brain Injury/Concussion In Children Presenting To Ed: A Qi Project, Niralee K. Rana, Nicole Gerber Md, Michael Alfonzo Md, Snezana Osorio Md, Deborah Levine Md

Rowan-Virtua Research Day

Background: Mild traumatic brain injuries (mTBI) or concussions account for high rates of emergency department (ED) visits. Concussion diagnoses are used less often in young children leading to a variability in parental education and discharge instructions. Lack of discharge guidance may increase parental anxiety, impact recovery, and increase ED visits.

Objectives: To increase the proportion of ED patients discharged with age-appropriate instructions for mTBI by 50% by June 1, 2024, and to determine the impact age-appropriate instructions have on decreasing parental anxiety.

Methods: This observational time series with planned sequential experimentation is in progress at a Pediatric ED affiliated with …


The Impact Of Stress During Adolescence And The Prevalence Of Pediatric Obesity, Olatunbosun Olakunri, Venkat Venkataraman May 2024

The Impact Of Stress During Adolescence And The Prevalence Of Pediatric Obesity, Olatunbosun Olakunri, Venkat Venkataraman

Rowan-Virtua Research Day

Obesity is a chronic condition that can be attributed to myriad factors including socioeconomic status, biological risk factors, and various environmental factors. These factors can be considered stress factors, and exposure to various levels of stress can impact the development of stress within the pediatric patients. The purpose of this study is to assess the association between the environmental, mental, social, physical, and psychological stress adolescents are exposed to and how they contribute to the prevalence of pediatric obesity throughout the United States. Understanding these risk factors can help us as a community and most importantly as clinicians develop better …


Pediatric Neurotropic Infection Alters Synaptic Development In The Developing Brain, Anuoluwapo Grace Fadare, Yashika S. Kamte, Manish N. Chandwani, Lauren A. O'Donnell May 2024

Pediatric Neurotropic Infection Alters Synaptic Development In The Developing Brain, Anuoluwapo Grace Fadare, Yashika S. Kamte, Manish N. Chandwani, Lauren A. O'Donnell

Rowan-Virtua Research Day

Many neurotropic viruses cause more significant pathology in younger hosts as their brains are still developing. This experiment asked how central nervous system (CNS) viral-infections affect the development of synapses in the pediatric brain during infection and post-infection. Synaptogenesis is at its peak in pediatric mice (10 days old) and we hypothesized that a neurotropic infection could disrupt synaptic proteins. We used a transgenic mouse model where measles virus (MV) infects only mature neurons, leading us to question whether synapses were impacted. We examined synaptic markers in the cerebellum and hippocampus in MV-infected and uninfected mice 9 days and 90 …


Increasing Equitable Access To Pediatric Specialty Care In Maine Through Implementation Of Econsults, David Ireland, Rachel Rockers, Sarah M. Gabrielson, Anya K. Cutler, Laura J. Faherty, Genevieve Whiting May 2024

Increasing Equitable Access To Pediatric Specialty Care In Maine Through Implementation Of Econsults, David Ireland, Rachel Rockers, Sarah M. Gabrielson, Anya K. Cutler, Laura J. Faherty, Genevieve Whiting

Costas T. Lambrew Research Retreat 2024

Introduction

•Barriers to accessing pediatric specialty care exist for many and are not experienced equally by all.

•eConsults are an asynchronous provider-provider referral modality to obtain low-barrier specialist input in place of some face-to-face (F2F) visits.

•We evaluated sociodemographic factors associated with referral to and receipt of specialist input before and after eConsult implementation at MaineHealth to examine equity implications.


Occupational Therapy Services In Pediatric Mental Health, Hallie Jerome May 2024

Occupational Therapy Services In Pediatric Mental Health, Hallie Jerome

Occupational Therapy Capstone Presentations

Children and youth experiencing mental health concerns often have limited or decreased engagement in meaningful occupations. Additionally, children and youth who experience mental health concerns at an early age are more likely to experience negative health outcomes such as poor occupational engagement, academic achievement, adverse childhood experiences (ACES), maltreatment/abuse/neglect, family and peer conflict/rejection, low self-esteem, early substance use, and many others impacting their overall health and well-being. My capstone project aimed to administer occupation-based interventions in a pediatric mental health program while I advance my skills working with an interdisciplinary team. The literature and needs assessment indicated a need for …


Animal-Assisted Therapy In An Outpatient Pediatric Occupational Therapy Setting, Peyton N. Stolle May 2024

Animal-Assisted Therapy In An Outpatient Pediatric Occupational Therapy Setting, Peyton N. Stolle

Occupational Therapy Capstone Presentations

The use of animals to assist in the healthcare industry has been around for some time now, however, only recently have those in the occupational therapy industry begun looking at the effects that it would have on patients within their scope of practice. Animal-assisted therapy (AAT) has various uses, and recent studies have shown that the use of dogs within a healthcare setting can greatly increase patient motivation and well-being. However, prior literature shows that there are limited studies on the effects of AAT in a pediatric occupational therapy (OT) setting, specifically an outpatient setting. My capstone project aimed to …


Approach For Defining Human Adenovirus Infection And Disease For Central Review Adjudication In Clinical Studies., Brian T. Fisher, Jesse Blumenstock, Craig L K Boge, Sydney Shuster, Alix E. Seif, Michael Green, Marian G. Michaels, Jessie L. Alexander, Monica I. Ardura, Tamara P. Miller, Diego R. Hijano, William J. Muller, Jennifer E. Schuster, Abby M. Green, Daniel E. Dulek, Adriana E. Kajon, Lara Danziger-Isakov May 2024

Approach For Defining Human Adenovirus Infection And Disease For Central Review Adjudication In Clinical Studies., Brian T. Fisher, Jesse Blumenstock, Craig L K Boge, Sydney Shuster, Alix E. Seif, Michael Green, Marian G. Michaels, Jessie L. Alexander, Monica I. Ardura, Tamara P. Miller, Diego R. Hijano, William J. Muller, Jennifer E. Schuster, Abby M. Green, Daniel E. Dulek, Adriana E. Kajon, Lara Danziger-Isakov

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Pediatric allogeneic hematopoietic cell transplant (allo-HCT) recipients are at risk for morbidity and mortality from human adenovirus (HAdV). HAdV can be detected in an asymptomatic state, referred to as infection or with signs or symptoms of illness, referred to as disease. Standardized case definitions are needed to distinguish infection from disease and allow for consistent reporting in both observational cohort studies and therapeutic clinical trials.

METHODS: A working group of experts in virology, transplant infectious disease, and HCT was assembled to develop HAdV infection and disease definitions with the degree of certainty (i.e., possible, probable, and proven). Definitions were …


Factors Associated With Hemoglobin Levels In Children Under 6 Months Of Age Hospitalized In A Pediatric Center In Peru, Víctor Alfonso Mamani-Urrutia, Rafael Durán-Galdo, Carlos Gonzales-Saravia, Alicia Bustamante-López, Rubén Espinoza-Rojas, Raffo Escalante-Kanashiro Apr 2024

Factors Associated With Hemoglobin Levels In Children Under 6 Months Of Age Hospitalized In A Pediatric Center In Peru, Víctor Alfonso Mamani-Urrutia, Rafael Durán-Galdo, Carlos Gonzales-Saravia, Alicia Bustamante-López, Rubén Espinoza-Rojas, Raffo Escalante-Kanashiro

Revista de la Facultad de Medicina Humana

Introduction: Anemia is a condition in which there is a low concentration of hemoglobin (Hb) levels. Although many causes of anemia have been identified, there are few studies in which they are related to epidemiological factors in the first months of life. Objective: To determine the factors associated with hemoglobin levels in children under 6 months of age hospitalized in a specialized pediatric center in Peru. Methods: To determine the factors associated with hemoglobin levels in children under 6 months of age hospitalized in a specialized pediatric center in Peru. Results: 61.4% of the infants were women, and only 6.7% …


Addressing The Physical Demands Of Caregiving Or Children With Disabilities In Nicaragua: A Quality Improvement Collaboration With Fne International, Grace Price Apr 2024

Addressing The Physical Demands Of Caregiving Or Children With Disabilities In Nicaragua: A Quality Improvement Collaboration With Fne International, Grace Price

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Many caregivers of children with disabilities experience chronic pain and related symptoms of cumulative physical trauma. This type of phenomenon is particularly prevalent in developing, low-income countries where environmental accommodations may not be as accessible. A quality improvement program, was conducted as a doctoral capstone project to create resources addressing the physical needs of caregivers of children with disabilities in Nicaragua. Program participants included teachers at a school for children with disabilities and special needs in Nicaragua. The primary project deliverable consisted of conducting an in-person workshop to train the teachers with evidence-based methods for preventing chronic pain and other …


The Impact Of Social Determinants Of Health On Adherence To Urinary Tract Infection Treatment: A Scoping Review, Barrett S. Patel, Ms, Bsn, Rn, Emily A. Gentry, Bsn, Rn, Sally Humphrey Dnp, Aprn, Cpnp-Pc, Bobby Bellflower Dnsc, Nnp-Bc, Faanp, Fnap Apr 2024

The Impact Of Social Determinants Of Health On Adherence To Urinary Tract Infection Treatment: A Scoping Review, Barrett S. Patel, Ms, Bsn, Rn, Emily A. Gentry, Bsn, Rn, Sally Humphrey Dnp, Aprn, Cpnp-Pc, Bobby Bellflower Dnsc, Nnp-Bc, Faanp, Fnap

Doctor of Nursing Practice Projects

Purpose/Background

Urinary tract infections (UTIs) are a common diagnosis among children. Patients must fully comply with treatment regimens to reduce the risk of recurring UTIs and prevent long-term complications. This scoping review aims to evaluate the literature and examine the association between screening for social determinants of health (SDH) and adherence to UTI treatment.

Methods

A thorough literature search via PubMed, Cochrane Library, Elsevier Clinical Key, CINAHL, and JAMA was conducted with the following keywords: Pediatric UTI, Adherence to Treatment Plans, Social Determinants of Health, Social Needs Screening, and others. Ten articles were appraised for their evidence and quality. The …


A Guide For Supplemental Education On Seating And Positioning For Parents And Caregivers Of Individuals With Cerebral Palsy, Grace Johnson, Mary Jan Greer, Franchesca Cox Apr 2024

A Guide For Supplemental Education On Seating And Positioning For Parents And Caregivers Of Individuals With Cerebral Palsy, Grace Johnson, Mary Jan Greer, Franchesca Cox

Spring 2024 Virtual OTD Capstone Symposium

An educational program that educates caregivers and families on the importance of proper seating and positioning during play, feeding, bone development and growth, speech, reaching, toy manipulation, handwriting and interacting with peers.


Adductor Canal Regional Anesthetic Placement In Pediatric Patients For Knee Arthroscopy: Defining The Optimal Location And Analysis Of Other Trends, Isaac Jin, Christine Song, Sujay Deshpande, Andrew Yang, Ethan Schollaert, Neha Divi, Aysha Hasan Md Apr 2024

Adductor Canal Regional Anesthetic Placement In Pediatric Patients For Knee Arthroscopy: Defining The Optimal Location And Analysis Of Other Trends, Isaac Jin, Christine Song, Sujay Deshpande, Andrew Yang, Ethan Schollaert, Neha Divi, Aysha Hasan Md

Tower Health Research Day

No abstract provided.


Consequences Of Negative Ureteroscopy For Pediatric Urolithasis: Single-Insitutional Cohort, Sonam Saxena, Yashaswi Parikh, Sami Shaikh, Aznive Aghababian, Suhaib Abdulfattah, Emily Ai, Karl Godlewski, Sahar Eftekharzadeh, Curran Uppaluri, Katherine Fischer, John Weaver, Christopher Long, Sameer Mittal, Aseem Shukla, Arun Srinivasan Apr 2024

Consequences Of Negative Ureteroscopy For Pediatric Urolithasis: Single-Insitutional Cohort, Sonam Saxena, Yashaswi Parikh, Sami Shaikh, Aznive Aghababian, Suhaib Abdulfattah, Emily Ai, Karl Godlewski, Sahar Eftekharzadeh, Curran Uppaluri, Katherine Fischer, John Weaver, Christopher Long, Sameer Mittal, Aseem Shukla, Arun Srinivasan

Tower Health Research Day

No abstract provided.


Occupational Impact Of Caregivers In Pediatric Palliative Care, Lezlye Ramos, Karen Park, Jazminne O. Arteaga Apr 2024

Occupational Impact Of Caregivers In Pediatric Palliative Care, Lezlye Ramos, Karen Park, Jazminne O. Arteaga

Spring 2024 Virtual OTD Capstone Symposium

The purpose of this study is to understand the occupational impact for caregivers who had a child with a life-limiting or life-threatening condition who had received pediatric palliative care. A lack of understanding of occupational therapy’s role in end-of-life care ultimately underutilizes and under-prepares occupational therapists to work in this practice area. Becoming a medical family caregiver, neglecting personal needs and desires becomes a norm having a in-direct effect on physical and psychological health and well-being. Findings from this study suggest that it is reasonable to infer that occupational participation among caregivers is influenced by finding time for self and …


Impact Of Fads Genotype On Polyunsaturated Fatty Acid Content In Human Milk Extracellular Vesicles: A Genetic Association Study, John J. Miklavcic, Natalie Paterson, Jennifer Hahn-Holbrook, Laura M. Glynn Apr 2024

Impact Of Fads Genotype On Polyunsaturated Fatty Acid Content In Human Milk Extracellular Vesicles: A Genetic Association Study, John J. Miklavcic, Natalie Paterson, Jennifer Hahn-Holbrook, Laura M. Glynn

Food Science Faculty Articles and Research

Background

Extracellular vesicles in human milk are critical in supporting newborn growth and development. Bioavailability of dietary extracellular vesicles may depend on the composition of membrane lipids. Single-nucleotide polymorphisms (SNPs) in the fatty acid desaturase gene cluster impact the content of long-chain polyunsaturated fatty acids in human milk phospholipids. This study investigated the relation between variation in FADS1 and FADS2 with the content of polyunsaturated fatty acids in extracellular vesicles from human milk.

Methods

Milk was obtained from a cohort of mothers (N = 70) at 2–4 weeks of lactation. SNPs in the FADS gene locus were determined using …


Strategies Over Knowledge: Training Gaps Present In Caring For Patients With Autism Spectrum Disorder For Pediatric And Student Nurses, Jasmine E. Johnson Apr 2024

Strategies Over Knowledge: Training Gaps Present In Caring For Patients With Autism Spectrum Disorder For Pediatric And Student Nurses, Jasmine E. Johnson

Honors Thesis

With Autism Spectrum Disorder (ASD) prevalence ever increasing among the pediatric population, nurses can expect to see an increase in the number of autistic patients within their clinical practice settings. Previous researchers have shown that pediatric nurses are required to overcome many barriers when working with autistic patients, and adequate training is necessary to achieve genuine patient-centered care. However, parents have reported less than optimal care received by their children with ASD within the healthcare system. Therefore, research is needed to determine where training could be improved for this patient population. This study aimed to identify where training deficits are …


Quality Of Life In A Cohort Of Kenyan Children With Cerebral Palsy, Pauline Samia, Melissa Tirkha, Amina Kassam, Richard Muindi, Wahu Gitakah, Susan Wamithi, James Orwa, Eugene Were, Michael Shevell Apr 2024

Quality Of Life In A Cohort Of Kenyan Children With Cerebral Palsy, Pauline Samia, Melissa Tirkha, Amina Kassam, Richard Muindi, Wahu Gitakah, Susan Wamithi, James Orwa, Eugene Were, Michael Shevell

Paediatrics and Child Health, East Africa

Aim: The objective of the study was to evaluate the quality of life in Kenyan children (age 4–18 years) with cerebral palsy (CP).

Methods: A cross-sectional descriptive study was conducted. Children with CP were recruited from the pediatric clinics at the Aga Khan hospital Nairobi (AKUHN). Parent proxy-reports using CPQoL-child and CPQoL-adolescents were obtained. Clinical and demographic data were compiled from medical records and parent interviews. A Likert scale was utilized to determine QoL across several domains.

Results: One hundred and fourteen child–parent dyads with CP were recruited. The median age of study participants was 8 years (IQR 3–13 years), …


Colors Of Connection: A Manual For Cultivating Social And Emotional Skills In Children With Disabilities Through Creative Arts, Allie Hertaus, Angela Labrie Blackwell Phd, Otr, Haleigh Freeman Otd, Otr/L Apr 2024

Colors Of Connection: A Manual For Cultivating Social And Emotional Skills In Children With Disabilities Through Creative Arts, Allie Hertaus, Angela Labrie Blackwell Phd, Otr, Haleigh Freeman Otd, Otr/L

Spring 2024 Virtual OTD Capstone Symposium

Children with disabilities (CWD) are experiencing occupational deprivation due to limited involvement in extracurricular activities. This deprivation impedes their development of social-emotional skills. In attempt to mitigate this deprivation, the OTD student created and implemented Colors of Connection, a creative arts based, social and emotional learning program into an already existing after school program for CWD.


Occupational Impacts Of Seizures, Stephanie Nailon, Karen Park, Kelly Rodenkirch Apr 2024

Occupational Impacts Of Seizures, Stephanie Nailon, Karen Park, Kelly Rodenkirch

Spring 2024 Virtual OTD Capstone Symposium

This research looks at the occupational impacts of seizure disorders on the adolescent population. The research study explores how their condition impacts the adolescent and family unit. The research was gathered from multiple perspectives to gain an in-depth understanding to best aid occupational therapists and health care professionals to gain a deeper understanding of areas to address when working with this population.


Recommendations For Sugammadex Administration In Standard And Special Populations, Kristen E. Mattson, Alexa Brummund Apr 2024

Recommendations For Sugammadex Administration In Standard And Special Populations, Kristen E. Mattson, Alexa Brummund

Doctor of Nursing Practice Projects

The purpose of this project was to collect evidence-based information regarding sugammadex administration in both standard and selected special populations. Special populations included renal failure, breastfeeding, pregnancy, and pediatrics. The objectives of the project were to collect and present current research to the host facility, define barriers to the use of sugammadex, and assess the participants’ knowledge of sugammadex use in special populations. A guideline for sugammdex administration was created and presented to the host facility through a poster presentation and quick reference guide. A voluntary post-implementation survey was implemented, and the results were recorded, analyzed, and displayed in the …


Pediatric Beta Blocker Therapy: A Comprehensive Review Of Development And Genetic Variation To Guide Precision-Based Therapy In Children, Adolescents, And Young Adults., Mollie Walton, Jonathan B. Wagner Mar 2024

Pediatric Beta Blocker Therapy: A Comprehensive Review Of Development And Genetic Variation To Guide Precision-Based Therapy In Children, Adolescents, And Young Adults., Mollie Walton, Jonathan B. Wagner

Manuscripts, Articles, Book Chapters and Other Papers

Beta adrenergic receptor antagonists, known as beta blockers, are one of the most prescribed medications in both pediatric and adult cardiology. Unfortunately, most of these agents utilized in the pediatric clinical setting are prescribed off-label. Despite regulatory efforts aimed at increasing pediatric drug labeling, a majority of pediatric cardiovascular drug agents continue to lack pediatric-specific data to inform precision dosing for children, adolescents, and young adults. Adding to this complexity is the contribution of development (ontogeny) and genetic variation towards the variability in drug disposition and response. In the absence of current prospective trials, the purpose of this comprehensive review …


Utility Of The Severity-Of-Illness Score For Toxic Epidermal Necrolysis (Scorten) In Pediatric Stevens-Johnson Syndrome Patients, Nina Kb Gust, Rebecca M. Adams, Ashley Frei, Michelle Coughlin Md, Justin Klein Md, Elika Ridelman Ph.D, Christina Shanti Md Mar 2024

Utility Of The Severity-Of-Illness Score For Toxic Epidermal Necrolysis (Scorten) In Pediatric Stevens-Johnson Syndrome Patients, Nina Kb Gust, Rebecca M. Adams, Ashley Frei, Michelle Coughlin Md, Justin Klein Md, Elika Ridelman Ph.D, Christina Shanti Md

Medical Student Research Symposium

Introduction

The Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) is a scoring system that seeks to predict in-hospital mortality for disorders affecting skin integrity. The scoring system has been validated and widely utilized in adults, but not pediatrics. This study aims to determine the accuracy of the SCORTEN in pediatrics.

Methods

A retrospective review of pediatric patients admitted at a verified pediatric burn center with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) from 2008 to 2022 was performed.

Results

Twenty-seven eligible SJS/TEN patients were identified. Three patients were excluded due to incomplete data, allowing twenty-four patients to be analyzed. Ten patients had …


Exploring The Relationship Of Varying Hydrocephalus Severity On Csf Dynamics In A Pediatric Hydrocephalus Rodent Model, Parker R. Fitzgerald, Grant Zydeck, Jeff Horbatiuk, Enoch Kim, Arjun Muralidharan, Carolyn A. Harris Phd Mar 2024

Exploring The Relationship Of Varying Hydrocephalus Severity On Csf Dynamics In A Pediatric Hydrocephalus Rodent Model, Parker R. Fitzgerald, Grant Zydeck, Jeff Horbatiuk, Enoch Kim, Arjun Muralidharan, Carolyn A. Harris Phd

Medical Student Research Symposium

Hydrocephalus causes neurological effects and high intracranial pressure (ICP) in the pediatric condition. Studies observing the relationship between ICP and cerebrospinal fluid (CSF) production in an electrical resistance model have been performed, but less has been done to define this relationship in living organisms. This study explored CSF flow dynamics as a consequence of hydrocephalus severity utilizing a novel model.

The model induced hydrocephalus in rats through injecting 30-50 micrometers of 25% (w/v) kaolin into the cisterna magna to obstruct CSF outflow. After 15-16 days of acclimation, the rats were anesthetized with isoflurane. A Transonic SP200 pressure transducer was inserted …


Vaccine Hesitancy Among Youth Living With Hiv In Detroit, Madeline B. Simone Mar 2024

Vaccine Hesitancy Among Youth Living With Hiv In Detroit, Madeline B. Simone

Medical Student Research Symposium

Vaccine hesitancy among youth with human immunodeficiency virus (HIV) was evaluated to determine if the pandemic affected vaccine acceptance. A retrospective chart review was conducted to analyze vaccine rates over a five-year (pre-post COVID) in one university-based clinic. Results indicated a variation in acceptance rates between vaccines, with the MenACWY, MenB, tetanus, and HPV having the highest acceptance rates and COVID-19 and annual flu vaccine having the lowest acceptance rates. Vaccine hesitancy did not correlate with HIV treatment hesitancy nor with aversion to needles. Negative messaging around vaccines from a variety of sources appeared to be the primary factor in …