Medicine and Health Sciences Commons^™

Moving Forward With Ketamine Therapy: Ensuring Safety, Efficacy, And Accessibility In Depression Treatment, Julienne Desanto

Undergraduate Honors Theses

Ketamine, a medication long used in anesthesia, has emerged as a promising treatment for depression and other mental health disorders. Its rapid onset of action and mechanism, which differs from traditional antidepressants by targeting NMDA receptors, offers a novel approach to managing depressive symptoms. Despite its potential, ketamine's use outside anesthesia, particularly in off-label ketamine clinics, is fraught with regulatory, safety, and accessibility challenges. This paper explores the historical medical use of ketamine and its emerging role in mental health treatment. It compares the efficacies and administration routes of different forms of ketamine, including intravenous (IV) and intranasal (nasal spray) …

Ketamine For Postpartum Depression: A Systematic Review, Jaylyn Thompson, David F. Lo, Alexis Foschini, Suvan Sundaresh, Don D. Shamilov

Rowan-Virtua Research Day

The purpose of this review is to explore perinatal ketamine’s potential for reducing postpartum depression after cesarean section. Articles reviewed from Pubmed, Cochrane, and Web of Science using specific search terms. 8 final papers were used for review after excluding duplicates and irrelevant titles and abstracts. Ketamine showed potential in reducing postpartum depression symptoms post C-section, although some studies reported no significant effects. All studies were randomized control trials. Ketamine may help prevent or lessen postpartum depression symptoms post C-section, but more research is needed to understand dosing and its casual relationship with PPD in this context.

Ketamine Crisis: Case Report On The Complications Of Ketamine Usage And Its Rise In The United States, Shika Veera, Vajreshwari Shivaprakash Md

Rowan-Virtua Research Day

The recreational use of ketamine poses various health risks, including addiction, cognitive impairments, and physical harm.

The patient is a 24-year-old female who presented with 30 lbs. unintentional weight loss, generalized weakness, and urinary incontinence over four months. She endorses right upper quadrant and suprapubic pain with occasional gross hematuria. The patient denied recreational drug use. Urine drug screen was negative. Gynecologic exam and STI testing were without concerns. On exam, she had positive right lower quadrant tenderness, suprapubic tenderness, and costovertebral angle tenderness bilaterally. The patient was admitted to the ICU due to weakness and significant hyponatremia at 115. …

Development Of Evidence-Based Practice Guidelines For Perioperative Multimodal Analgesia During Spine Surgery, Jonathan Wagner

Doctor of Nursing Practice Scholarly Projects

The most common cause of adult disability is chronic back pain. As medication maintenance therapy becomes ineffective, surgical intervention is the last resort for treatment. Patients with chronic pain often rely on pain medication such as opioids for relief. The exposure and dependency of opioids can create unique challenges for anesthesia providers to deliver safe and adequate anesthesia for surgery. Patient’s dependent on chronic opioids develops many adverse effects including sleep disordered breathing, suppression of the immune system, and higher risk of developing cardiovascular events under stress. There is a lack of consistent perioperative guidelines for patients undergoing spinal surgery …

Comparison Of Ketamine-Xylazine, Butorphanol-Azaperone-Medetomidine, And Nalbuphine-Medetomidine-Azaperone For Raccoon (Procyon Lotor) Immobilization, Shylo R. Johnson, Christine K. Ellis, Chad Wickham, Molly R. Selleck, Amy T. Gilbert

USDA Wildlife Services: Staff Publications

Raccoons (Procyon lotor) are frequently handled using chemical immobilization in North America for management and research. In a controlled environment, we compared three drug combinations: ketamine-xylazine (KX), butorphanol-azaperone-medetomidine (BAM), and nalbuphinemedetomidine- azaperone (NalMed-A) for raccoon immobilization. In crossover comparisons, raccoons received a mean of the following: 8.66 mg/kg ketamine and 1.74 mg/kg xylazine (0.104 mL/kg KX); 0.464 mg/kg butorphanol, 0.155 mg/kg azaperone, and 0.185 mg/kg medetomidine (0.017 mL/kg BAM); and 0.800 mg/kg nalbuphine, 0.200 mg/kg azaperone, and 0.200 mg/kg medetomidine (0.020 mL/kg NalMed-A). Induction time was shortest with KX (mean6SE, 10.060.7 min) and longest with NalMed-A (13.061.3 min). …