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Full-Text Articles in Medicine and Health Sciences

The Investigation Between Voiding Function Medication And The Risk Of Bladder Cancer In Patients With Spinal Cord Injury, Kai-Hua Chen, Ting-Yao Wang, Chien-Min Chen, Chuan-Pin Lee, Yao-Hsu Yang, Chu-Hsu Lin, Kuan-Yu Kung, Vincent Chin-Hung Chen Dec 2021

The Investigation Between Voiding Function Medication And The Risk Of Bladder Cancer In Patients With Spinal Cord Injury, Kai-Hua Chen, Ting-Yao Wang, Chien-Min Chen, Chuan-Pin Lee, Yao-Hsu Yang, Chu-Hsu Lin, Kuan-Yu Kung, Vincent Chin-Hung Chen

Rehabilitation Practice and Science

Bladder cancer (BC) is a chronic complication of spinal cord injury (SCI). Limited studies have focused on the risks of BC in SCI patients using voiding function medication for bladder dysfunction. In this retrospective, national-wide, population-based cohort study, SCI patients with registration in the National Health Insurance Research Database (NHIRD) from 1998 to 2013 were included. We investigated the risk of BC in SCI patients administered voiding function medications and other comorbidities by 2-year landmark analysis. SCI patients were divided into medication user (bethanechol, oxybutynin, or tolterodine) and non-medication user groups at landmark period. They were followed until the development …


Molecular Drivers Of Bladder Cancer Motility, Bryan Wehrenberg May 2021

Molecular Drivers Of Bladder Cancer Motility, Bryan Wehrenberg

Dissertations & Theses (Open Access)

Bladder cancer (BC) progression is measured by the degree of tumor cell invasion into the bladder wall and dissemination to distant sites. The study of BC cell motility will both enable development of anti-invasion therapeutics to limit progression of early-stage disease and improve our understanding of the metastatic process which drives patient mortality in BC. BCs display a great deal of intertumoral heterogeneity, and can be divided into basal and luminal subtypes, which are biologically and clinically distinct entities. Here, I examine the invasion phenotypes of BC as a function of both subtype and epithelial to mesenchymal transition (EMT) status. …


Towards The Point Of Care And Noninvasive Classification Of Bladder Cancer From Urine Sediment Infrared Spectroscopy. Spectral Differentiation Of Normal, Abnormal And Cancer Patients, Monika Kujdowicz, David Perezguaita, Piotr Chłosta, Krzysztof Okon, Kamilla Malek Jan 2021

Towards The Point Of Care And Noninvasive Classification Of Bladder Cancer From Urine Sediment Infrared Spectroscopy. Spectral Differentiation Of Normal, Abnormal And Cancer Patients, Monika Kujdowicz, David Perezguaita, Piotr Chłosta, Krzysztof Okon, Kamilla Malek

Articles

Bladder cancer (BC) is the 9th cancer cause of death and one of most cost-intensive in the world. The diagnostic tools are still not at all satisfactory. Herein we evaluated the potential of infrared spectroscopy to detect molecular changes that precede and accompany the carcinogenesis in voided urine sediment. We collected 165 samples from patients being diagnosed for BC and measured them with attenuated total reflectance Fourier transformed infrared spectroscopy (ATR FTIR). Samples were primarily divided into three groups according to cytology that indicated the presence of normal, abnormal and cancer cells. ATR FTIR spectra of sediments were analyzed with …


Supporting Patient Education On Bladder Cancer And Risk Factors Specific To Vermont, Evan Gaston Jan 2021

Supporting Patient Education On Bladder Cancer And Risk Factors Specific To Vermont, Evan Gaston

Family Medicine Clerkship Student Projects

Physician and patient education materials regarding the incidence of bladder cancer in Vermont, the absence of recommended screening, and discussion of risks of bladder cancer with emphasis on private well water testing through the Vermont Department of Health.