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Full-Text Articles in Medicine and Health Sciences
Cerebrovascular Dysfunction Is Related To Depressive Symptom Severity In Young Adults, Rauchelle E. Richey, John Akins, Jeremiah C. Campbell, Erika F.H. Saunders, R Matthew Brothers, Jody L. Greaney
Cerebrovascular Dysfunction Is Related To Depressive Symptom Severity In Young Adults, Rauchelle E. Richey, John Akins, Jeremiah C. Campbell, Erika F.H. Saunders, R Matthew Brothers, Jody L. Greaney
International Journal of Exercise Science: Conference Proceedings
Cerebral vasodilatory responsiveness is blunted in older adults (~70 yrs) with depressive disorders and is thought to contribute to the link between depressive symptomology and increased risk for neurocognitive (e.g., dementia) and cerebral vascular (e.g., stroke) diseases. In young adults with major depressive disorder (MDD), peripheral vascular endothelial dysfunction is present and graded in relation to the severity of depressive symptoms; however, to date, limited investigations have examined cerebral vasodilatory function in young otherwise healthy adults with MDD. PURPOSE: We tested the hypothesis that cerebral vasodilatory responsiveness to a hypercapnic stimulus would be blunted in young otherwise healthy adults …
The Relation Between Cognitive Function And Cerebral Vasodilatory Reactivity In Young Adults With Major Depressive Disorder, Salwa Shoaib, Rauchelle E. Richey, Sherri M. Pham, John D. Akins, Dahlia Mukherjee, Erika F.H. Saunders, R Matthew Brothers, Jody L. Greaney
The Relation Between Cognitive Function And Cerebral Vasodilatory Reactivity In Young Adults With Major Depressive Disorder, Salwa Shoaib, Rauchelle E. Richey, Sherri M. Pham, John D. Akins, Dahlia Mukherjee, Erika F.H. Saunders, R Matthew Brothers, Jody L. Greaney
International Journal of Exercise Science: Conference Proceedings
Major depressive disorder (MDD) has been associated with an elevated risk of developing neurocognitive diseases (e.g., dementia). Although the precise neurobiological mechanisms remain incompletely understood, cerebrovascular dysfunction is thought to directly contribute, at least in part, to impairments in cognitive function. Cerebral vasodilatory reactivity to a hypercapnic stimulus is blunted in older adults with MDD compared to age-matched non-depressed adults. Further, impaired cerebral vasodilation has been linked to reduced cognitive activity in older adults with depression. However, to date, limited studies have examined the relation between cognitive function and cerebrovascular function in otherwise healthy young adults with MDD. PURPOSE: …