Medicine and Health Sciences Commons^™

Chloroquine Induction Par-4 And Treatment Of Cancer, Vivek M. Rangnekar

Radiation Medicine Faculty Patents

Described herein are methods for treating cancer in a subject in need thereof by administering chloroquine, or a salt or prodrug thereof, optionally with another agent that promotes Par-4 production to induce prostate apoptosis response-4 (Par-4) production by host cells, particularly non-cancerous host cells, to promote apoptosis in cancer cells, including androgen insensitive prostate cancer cells.

Characterization Of The Effect Of Exercise Dose And Integrative Nonpharmacological Therapies In The Treatment Of Chronic Pain, Anna M. Polaski

Electronic Theses and Dissertations

Chronic pain includes debilitating conditions affecting large populations of people throughout the world. These diseases are further complicated by comorbid psychological disorders which make chronic pain conditions difficult to treat. Nonpharmacological treatment options have more recently become an important mainstay of effective therapies and are currently being used to supplement or replace traditional pharmacological treatment methods. Exercise-based therapies in particular are of interest due to their demonstrated success in reducing pain symptoms as well as improving psychological outcomes. Dose is an important factor in being able to effectively prescribe treatments in the context of specific exercise interventions and specific pain …

Role Of Echocardiography In Diagnostic Evaluation Of Patients Admitted To Observation Unit., Muhammad Arslan Cheema, Hafez Mohammad Ammar Abdullah, Waqas Ullah, Yasar Sattar, Shujaul Haq, Khadija Cheema, Asrar Ahmad, Zain Ali, Asoka Balaratna

Abington Jefferson Health Papers

BACKGROUND: Syncope is a transient loss of consciousness due to transient decrease in cerebral perfusion. Syncope accounts for a 3-6% of all emergency department visits. Etiology of syncope can be neural, cardiogenic, or vascular. Previous studies have evaluated the types and management of syncope. Echocardiography is a commonly used test in the evaluation of causes of syncope. Whether the benefit compared to financial burden of this diagnostic study is in all subsets of syncope cases remains unclear.

AIM: To evaluate the impact of echocardiography in the diagnostic evaluation of syncope and to evaluate the subset of patients that would benefit …

El Vph Y El Cáncer Cervical En El Perú: Diferencias De Accesibilidad Entre Las Mujeres De Las Zonas Rurales Y Urbanas / Hpv And Cervical Cancer In Peru: The Differences In Accessibility For Rural And Urban Women, Jemma Stratton

James Madison Undergraduate Research Journal (JMURJ)

Este informe examina el estado actual del tratamiento y prevención del VPH en el Perú, y pone énfasis con problemas específicas que han contribuido al riesgo alto de cáncer cervical entre las mujeres rurales. Perú ha tomado grandes pasos en las décadas últimas para establecer programas que se dirigen al VPH y la salud de las mujeres. Sin embargo, las mujeres peruanas tienen una población más probable para contraer cáncer cervical en el mundo. Este informe compara los esfuerzos de prevención del VPH entre las poblaciones rurales y urbanas en el Perú y identificar las barreras que causando esta crisis …

Size Matters: A Case Of Recurrent Proximal Esophageal Stenoses Treated With A Biliary Self Expanding Metal Stent (Sems), Sahityan Viswanathan, Timothy Dobin, Long T. Hoang

Gastroenterology

Esophageal stenosis after radiotherapy occurs in up to 15% of patients within three months of treatment. Endoscopic dilation remains the standard of care for cervical esophageal stenosis with refractory cases requiring stenting. Proximal stenosis poses a challenge as standard esophageal stents can cause cervicalgia and globus sensation due to their size and expansive force. We report on the usage of a biliary SEMS for a severe-recurrent stricture at the level of the proximal esophageal sphincter.

Rare Infective Endocarditis Caused By Dental Source Due To Streptococcus Bovis Masquerading As Cardiac Failure, Ravish Patel, Pratikkumar Vekaria, Devin Vaishnani, Johnnie Mao, Asif Shah

Internal Medicine

No abstract provided.

Contrasting Adult And Emerging Adult Women On Possible Psychosocial And Behavioral Correlates Of Short-Term Weight Loss, James J. Annesi, Ping H. Johnson

Health Behavior Research

Physical activity could be associated with psychosocial correlates of changes in eating behaviors required for weight loss. This field investigation assessed relationships of physical activity with early changes in psychosocial variables such as depression, fatigue, and body satisfaction; and their effect on fruit/vegetable and sweets intake and weight change. Emerging adult women from a university setting (M_age = 20.4 years, SD = 2.0; n = 36) and adult women from a community health-promotion setting (M_age = 45.6 years, SD = 7.3; n = 36), participating in the same cognitive-behavioral weight-loss program that initiated physical activity prior …

An Interdisciplinary Approach For Treating Children With Cerebral Palsy, Magen Keys, Connie Lewis

Journal of Interprofessional Practice and Collaboration

Cerebral Palsy (CP) is a neurological disorder that affects the brain and muscles, often causing motor and social delays. Children diagnosed with CP often require interdisciplinary care to promote quality of life and improved development of motor and social skills. Interdisciplinary teams made up of families, the patient, nurses and therapists allow for ongoing goal setting and communication of treatment plans. Each member of the team plays a significant role as they offer specialized services to enhance not only the patient’s physical development but also

the child’s ability to build social relationships, promote autonomy, and encourage independence.

An interdisciplinary approach …

Infections In Patients With Multiple Myeloma Treated With Conventional Chemotherapy: A Single-Center, 10-Year Experience In Pakistan, Mohammad Faizan Zahid, Natasha Ali, Myra Nasir, Maria Haider Baig, Mustafa Iftikhar, Syed Usman Bin Mahmood, Arhama Malik, Sara Atif, Mohammad Asim Beg

Department of Pathology and Laboratory Medicine

Introduction: Multiple myeloma (MM) is a common hematologic malignancy with variable degrees of immunodeficiency. Disease- and treatment-related compromise of the immune system predisposes patients to infections, which are a major cause of morbidity and mortality.
Objective: We aimed to establish the incidence and main characteristics of infections in MM patients treated at our center over a 10-year period.
Method and results: Of the 412 patients retrospectively analyzed, 154 (37.4%) were documented to have at least one episode of infection and were included in this study. A total of 244 infectious episodes were documented. The most common site of infection was …

Clinical Value Of Ultrasonography For Monitoring Angular Pregnancy In First-Trimester, Yanhua Zhen, Md, Xuefeng Lu, Md, Chenyu Wang, Md, Huixia Li, Md, Ji-Bin Liu, Md

Department of Radiology Faculty Papers

Objective: To explore the clinical value of ultrasonography for early detection and monitoring of angular pregnancy during the first-trimester.

Methods: For this retrospective study, we enrolled 23 patients with asymptomatic angular pregnancy who were diagnosed by ultrasound at early pregnancy and who underwent ultrasound follow-up to determine its clinical outcome. An ultrasound unit E8 (GE Healthcare, Milwaukee, WI) associated with a 5-9 MHz convex array transvaginal probe was used to image the gestational sac by both two-dimensional and three-dimensional modes. Transvaginal sonographic observation included the location, size, and shape of the gestational sac, as well as the relationship between the …

Current Management Of Glioma In Pakistan, Umme E Hani Abdullah, Altaf Ali Laghari, Muhammad Usman Khalid, Huzaifa Bin Rashid, Fatima Ali, Adnan Jabbar, Asim Hafiz, Muhammad Shahzad Shamim, Ather Enam

Section of Neurosurgery

To date, information on the management of specific neurosurgical tumors, such as glioma, in Pakistan remains scattered and scarce. Our review synthesizes the predicaments of glioma management routinely presented to the neurosurgery, medical oncology, radiation oncology, and radiology departments in Pakistan. Expert opinions were integrated from each of the relevant fields in the form of personal citations. The data presented in our review were collected from various PubMed and non-PubMed indexed articles, coupled with various health reports from the Government of Pakistan along with the World Health Organization. Through these data, it was postulated that the utilization of innovative and …

Operative Versus Conservative Treatment Of Clavicular And Scapular Fractures, Chase Davis

Theses and Graduate Projects

Background: Clavicle fractures and scapula fractures represent up to 4% and 1% of all fractures, respectively.^1-4,9-11 Historically, both fracture types have been treated conservatively with acceptable outcomes. The surgical correction of these fractures is currently being investigated as a viable alternative to conservative management.

Method: A systematic search of PubMed was performed to identify articles comparing open reduction and internal fixation (ORIF) with conservative treatment for both clavicular and scapular fractures. Specific outcomes of interest were shoulder function, pain, strength, range of motion, and risk of nonunion.

Results: ORIF of midshaft clavicular fractures results in increased shoulder function within …

Effects Of Visit Frequency On Swallowing Function During Organ Preservation For Head And Neck Cancer, Mathew Blaine Vansant

LSU Doctoral Dissertations

Chemoradiotherapy is not without risk of injury to the muscles and nerves associated with swallowing function. Current research supports the use of prophylactic behavioral swallowing exercise in the HNC population, however, wide variations in swallowing treatment methodologies exist and no optimal SLP-patient visit frequency has been established. In addition, poor patient adherence to swallowing exercise appears prevalent. The current study explored the impact of speech language pathologist (SLP)-patient contact time, adherence to prophylactic behavioral swallowing exercises, and explored effects of exercise intensity on immediate post-radiation swallowing outcomes. Groups included a high frequency group (5 weekly SLP-patient visits, n = 15), …

Prevalence Of Dyskinesia And Off By 30-Minute Intervals Through The Day And Assessment Of Daily Episodes Of Dyskinesia And Off: Novel Analyses Of Diary Data From Gocovri Pivotal Trials., Robert A. Hauser, Daniel Kremens, Lawrence W. Elmer, David L. Kreitzman, Ryan R. Walsh, Reed Johnson, Robert Howard, Jack T. Nguyen, Rajiv Patni

Department of Neurology Faculty Papers

BACKGROUND: Parkinson's disease (PD) patients using levodopa commonly develop dyskinesia and OFF episodes that reduce quality of life.

OBJECTIVE: Evaluate prevalence of troublesome dyskinesia and OFF through the day, assessed by 30-minute intervals, as well as the mean number and duration of troublesome dyskinesia and OFF episodes, transitions between PD states, and effects of Gocovri® (amantadine) extended release capsules on these episodes.

METHODS: Evaluate diary data from pooled Gocovri phase 3, placebo-controlled trials-analyzed for 17 hours following wake-up-at baseline and week 12.

RESULTS: Diaries were evaluable for 162 patients. At baseline, 67% of patients woke up OFF, with prevalence decreasing …

Acceptability Of Active Case Finding With A Seed-And-Recruit Model To Improve Tuberculosis Case Detection And Linkage To Treatment In Cambodia: A Qualitative Study, Sovannary Tuot, Alvin K. J. Teo, Danielle Cazabon, Say Sok, Mengieng Ung, Sangky Ly, Sok Chamreun Choub, Siyan Yi

Background

With support of the national tuberculosis (TB) program, KHANA (a local non-governmental organization in Cambodia) has implemented an innovative approach using a seed-and-recruit model to actively find TB cases in the community. The model engaged community members including TB survivors as seed and newly diagnosed people with TB as recruiters to recruit presumptive TB cases in their social network in a snowball approach for screening and linkage to treatment. This study aimed to explore the acceptability of the active case finding with the seed-and-recruit model in detecting new TB cases and determine the characteristics of successful seeds.

Methods

This …

The Suffering Of Schizophrenia: Stigma, Enigma And The Search For A Cure, Fatima Sheikh

MSJ Capstone Projects

Patients suffering from Schizophrenia, a severe mental illness, firmly believe in their delusions due to a loss of connection with reality and creation of an imaginary world. Generally, diagnosis and treatment of the mental disorder have been ignored due to cultural and social setup in Karachi. Schizophrenia cannot be cured but manageable with lifetime medicines and rehabilitation after each lapse. The purpose of my investigative piece is to highlight the stigma attached to Schizophrenia along with a search for its treatment.

A Systematic Review And Analysis Of Racial Differences In Treatment For Depression, Elli D. R. Parisi

DePaul Discoveries

Mental health affects a large proportion of the population across the world. Though many mental health studies exist, they are inconsistent in methodology, conceptualization of terms, and populations studied; as a result, many studies are incomparable with each other. Further, there is arguably too few studies that focus on marginalized or underrepresented populations. The current study aims to address some of this gap in knowledge. The differences in the way depression is diagnosed and treated in various racial and ethnic groups were identified, and the findings of previous studies were analyzed to help improve the way mental health, and specifically …

Initial Management Of Meningiomas: Analysis Of The National Cancer Database, Catherine R. Garcia, Stacey A. Slone, Monica Chau, Janna H. Neltner, Thomas A. Pittman, John L. Villano

Neurology Faculty Publications

BACKGROUND: Meningiomas are the most common central nervous system tumor. We describe current trends in treatment and survival using the largest cancer dataset in the United States.

METHODS: We analyzed the National Cancer Database from 2004 to 2014, for all patients with diagnosis of meningioma.

RESULTS: 201,765 cases were analyzed. Patients were most commonly White (81.9%) females (73.2%) with a median age of 64 years. Fifty percent of patients were diagnosed by imaging. Patients were reported as grade I (24.9%), grade II (5.0%), grade III (0.7%), or unknown WHO grade (69.4%). Patients diagnosed by imaging were older, received treatment in …

Recovery And Person-Centered Care In Gambling Disorder, Angels Gonzalez-Ibanez Phd In Psychology, Adjunct Professor

International Conference on Gambling & Risk Taking

No abstract provided.

Exploring The Impact Of Challenging Behaviors On Treatment Efficacy In Autism Spectrum Disorder, Juliana Hoag

Computational and Data Sciences (MS) Theses

The focus of this study was to explore the impact of challenging behaviors on Applied Behaviors Analysis treatment in Autism Spectrum Disorder. The prevalence of ASD is on the rise, so it is important that we understand how patients are responding to treatment. In this study, we cluster patients (N=854) based on their eight observed challenging behaviors using k-means, a machine learning algorithm, and then perform a multiple linear regression analysis to find significant differences between average exemplars mastered. The goal of this study was to expand the research in the area of ABA treatment for ASD and to help …

Lipid Emulsion And The Management Of Local Anesthetic Systemic Toxicity, Randall Hagemeister

Nursing Capstones

No abstract provided.

Hepatitis C Treatment In High Risk Patients: Implementation Of A Successful Community Focused Program, Annie Pedlar, Jodie Sandhu Dnp, Fnp-C

Doctor of Nursing Practice (DNP) Projects

Background: The city of San Francisco boasts a high rate of hepatitis C infection (HCV) among IV drug users indicating the need for a hepatitis C treatment program. It is estimated that over two-thirds of people who are actively infected with HCV are IV drug users (EndHepCSF, 2017), and in 2017 the San Francisco Department of Public Health (SFDPH) estimated that there are 22,500 active people who inject drugs (PWID) in SF (SFDPH, 2017). With the presence of a wide population of IV drug users in SF there is an identified need for intervention to treat this high-risk patient …

Use Of Memantine In Autism Spectrum Disorder: A Case Report, Adam Schindzielorz Md, Kristina Bryant-Melvin Md, Suzanne Holroyd Md, Kelly Melvin Md

Kristina Bryant-Melvin

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder of varying severity and phenotypic expression that is characterized by persistent deficits in social relatedness, communication skills, and interfering repetitive behaviors. Associated behavioral pathology can include inattention, aggression, irritability, hyperactivity, anxiety, and self-injury. Currently, FDAapproved treatments exist to treat secondary symptoms but not core symptomatology. The etiology of autism and other ASD is thought to be multifactorial but is not well understood. Some studies suggest that glutamate excitotoxicity may play a role in the pathogenesis of ASD. Memantine, an NMDAreceptor antagonist, could potentially address core symptoms in ASD by targeting disease-specific pathophysiology. …

Addiction Panel Discussion: Finding Support, Karen Yost, Matthew Q. Christiansen M.D., M.P.H., Lyn M. O'Connell Ph.D., Dan Curry, Amy Saunders, Michelle Perdue, Sabrina Thomas

Matthew Christiansen

“Addiction Panel Discussion: Finding Support,” is the third of five in the, “Don’t Call Me Crazy: MU Mental Health Initiative,” panel discussion series, which was held on January 24, 2019. This initiative is comprised of three major components: “Resiliency through Education;” which includes: panel discussions with mental health professionals and a research guide, “Resiliency through Art;” an art exhibition that featured works form MU students, faculty and staff, and community members, and “Resiliency through Community;” an extensive collection of campus, local, state, and national mental health resources. Libraries hold a unique position as places to hold civil conversations on challenging …

Addiction Panel Discussion: Finding Support, Karen Yost, Matthew Q. Christiansen M.D., M.P.H., Lyn M. O'Connell Ph.D., Dan Curry, Amy Saunders, Michelle Perdue, Sabrina Thomas

Sabrina Thomas

“Addiction Panel Discussion: Finding Support,” is the third of five in the, “Don’t Call Me Crazy: MU Mental Health Initiative,” panel discussion series, which was held on January 24, 2019. This initiative is comprised of three major components: “Resiliency through Education;” which includes: panel discussions with mental health professionals and a research guide, “Resiliency through Art;” an art exhibition that featured works form MU students, faculty and staff, and community members, and “Resiliency through Community;” an extensive collection of campus, local, state, and national mental health resources. Libraries hold a unique position as places to hold civil conversations on challenging …

Disordered Eating Panel Discussion: Finding Help, Kelli Williams Ph.D., R.D., L.D., Candace Layne Ed.D., Alps, Lpc, Ncc, James R. Bailes M.D., Kristina M. Bryant-Melvin M.D., Licia Rei, Brittany Chapman, Tiffany Bowes, Sabrina Thomas

Sabrina Thomas

“Disordered Eating Panel Discussion: Finding Help,” is the fourth of five in the, “Don’t Call Me Crazy: MU Mental Health Initiative,” panel discussion series, which was held on February 21, 2019. This initiative is comprised of three major components: “Resiliency through Education;” which includes: panel discussions with mental health professionals and a research guide, “Resiliency through Art;” an art exhibition that featured works form MU students, faculty and staff, and community members, and “Resiliency through Community;” an extensive collection of campus, local, state, and national mental health resources. Libraries hold a unique position as places to hold civil conversations on …

Hepatitis C Virus Screening And Treatment, Dani Loftus, Emily Machens, Crista Jamous

Doctor of Nursing Practice Projects

Hepatitis C Virus (HCV) is classified as a contagious liver disease that can be either acute or chronic, and the illness ranges in severity from mild to lifelong. It is estimated that 2.7 million people in the United States (US) have HCV, but only half are diagnosed. The CDC recommends testing by birth-cohort, focusing on adults born between 1945 and 1965. Three main objectives for this project included implementation of a clinical decision support system (CDSS) for providers, increasing HCV screening by providing education to the support staff in primary care clinics of a local hospital which would increase the …

Efficacy Of Problem-Solving Interventions For Improving Executive Functioning Outcomes In Patients With Acquired Brain Injuries: A Systematic Review, Rebecca Booth, Emily Heckler, Molly Reese

Communication Sciences and Disorders: Systematic Review Publications

Background and Objective(s): Individuals with acquired brain injury (ABI) often demonstrate executive functioning (EF) impairments that impact their ability to identify and solve problems within their daily lives. This systematic review attempts to consolidate available research supporting problem-solving interventions as effective, evidence-based practice for addressing EF deficits in individuals with ABI.

Methods: A systematic review was conducted using the databases Ovid Medline, CINAHL, and PsycINFO. Studies met the following inclusion criteria: 1) problem-solving intervention, 2) EF outcomes, 3) individuals with acquired brain injuries. Studies were excluded based on the following criteria: 1) single case study design, 2) family-centered interventions and …

Non-Pharmacological Approaches To Stress Reduction And The Treatment Of Migraines, Megan O'Connell

Senior Honors Projects

Migraines are a disabling neurological medical condition that affects about 12% of the population. Traditionally, migraines are managed with medication however many patients still experience migraines even while on medication. Stress reduction methods such as meditation, deep breathing, reiki, yoga and hypnosis can help with the treatment of a variety of diseases. This study examines the effects of these non-pharmacological treatments on migraines. First, a systematic literature review was completed to explore the effectiveness of alternative treatment approaches. Twenty-four studies were included in the review and the literature concluded patients with migraines can benefit from psychological interventions. Second, a qualitative …

Complex Trauma: Counselors' Self-Efficacy And Treatment, Breeze Valenska Rueda

Theses and Dissertations

The purpose of this descriptive and exploratory mixed-method study was twofold: to explore counselors’ perceptions and knowledge regarding complex trauma and, assess counselors’ perceptions regarding their level of confidence when working with this population. The study determined what relevant factors were related to counselors’ perceived self-efficacy concerning complex trauma. Although complex trauma is emerging as an important issue, there is limited research regarding counselors’ experiences with complex trauma. The current study explored participants’ perceptions when providing services to individuals with prolonged and cumulative trauma and provided a greater understanding of counselors’ recognition and selfefficacy when working with this population. A …