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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Hydroxyl Radical Formation In The Gas Phase Oxidation Of Distonic 2-Methylphenyl Radical Cations, Matthew Prendergast, Phillip A. Cooper, Benjamin B. Kirk, Gabriel Da Silva, Stephen J. Blanksby, Adam J. Trevitt
Hydroxyl Radical Formation In The Gas Phase Oxidation Of Distonic 2-Methylphenyl Radical Cations, Matthew Prendergast, Phillip A. Cooper, Benjamin B. Kirk, Gabriel Da Silva, Stephen J. Blanksby, Adam J. Trevitt
Adam Trevitt
The reactions of distonic 4-(N,N,N-trimethylammonium)-2-methylphenyl and 5-(N,N,N-trimethylammonium)-2-methylphenyl radical cations (m/z 149) with O 2 are studied in the gas phase using ion-trap mass spectrometry. Photodissociation (PD) of halogenated precursors gives rise to the target distonic charge-tagged methylphenyl radical whereas collision-induced dissociation (CID) is found to produce unreactive radical ions. The PD generated distonic radicals, however, react rapidly with O2 to form [M + O2]•+ and [M + O2 - OH]•+ ions, detected at m/z 181 and m/z 164, respectively. Quantum chemical calculations using G3SX(MP3) and M06-2X theories are deployed to examine key decomposition pathways of the 5-(N,N,N-trimethylammonium)-2-methylphenylperoxyl radical and rationalise …
Exploring The Geography Of Serious Mental Illness And Type 2 Diabetes Comorbidity In Illawarra-Shoalhaven, Australia (2010 -2017), Ramya Walsan, Darren J. Mayne, Nagesh B. Pai, Xiaoqi Feng, Andrew D. Bonney
Exploring The Geography Of Serious Mental Illness And Type 2 Diabetes Comorbidity In Illawarra-Shoalhaven, Australia (2010 -2017), Ramya Walsan, Darren J. Mayne, Nagesh B. Pai, Xiaoqi Feng, Andrew D. Bonney
Illawarra Health and Medical Research Institute
Objectives The primary aim of this study was to describe the geography of serious mental illness (SMI)-type 2 diabetes comorbidity (T2D) in the Illawarra-Shoalhaven region of NSW, Australia. The Secondary objective was to determine the geographic concordance if any, between the comorbidity and the single diagnosis of SMI and diabetes. Methods Spatial analytical techniques were applied to clinical data to explore the above objectives. The geographic variation in comorbidity was determined by Moran's I at the global level and the local clusters of significance were determined by Local Moran's I and spatial scan statistic. Choropleth hotspot maps and spatial scan …
Synthesis Of N-Heterocyclic Molecules And Their Applicability Towards Ion Sensing: Polymeric Chemosensors, Aikohi M. Ugboya
Synthesis Of N-Heterocyclic Molecules And Their Applicability Towards Ion Sensing: Polymeric Chemosensors, Aikohi M. Ugboya
Electronic Theses and Dissertations
Critical to biological and environmental processes are anions because often times their relative concentration in our body can be an indicator of one’s well-being. Therefore, highly sensitive and cost-efficient methods for ions recognition is necessary for human health. In recent times, polymeric chemosensors have become a vital tool for sensing ions because of its higher sensitivity and good mechanical properties compared to their monomeric counterparts. These sensors are designed to produce a measurable response in the presence of a targeted ion such as an electrochemical or optical signal. The unique structure and the photophysical properties of the 1,2,3-triazole core coupled …
Synthesis And Biological Evaluation Of 2,4-Diaminopyrimidine-5-Carbonitrile And N-(2-Amino-5-Cyanopyrimidin-4-Yl)Benzamide Derivatives As Egfr Inhibitors, Pathan Sultan Ismail, Irfan Khan, Vivek Kumar Kashyap, Ved Prakash Verma, Monika Shukla, Anupam Dhasmana, Shashi Pandey, Girdhar Pal Singh, Shahnawaz Khan, Jaybir Singh
Synthesis And Biological Evaluation Of 2,4-Diaminopyrimidine-5-Carbonitrile And N-(2-Amino-5-Cyanopyrimidin-4-Yl)Benzamide Derivatives As Egfr Inhibitors, Pathan Sultan Ismail, Irfan Khan, Vivek Kumar Kashyap, Ved Prakash Verma, Monika Shukla, Anupam Dhasmana, Shashi Pandey, Girdhar Pal Singh, Shahnawaz Khan, Jaybir Singh
School of Medicine Publications and Presentations
A series of 2,4-diaminopyrimidine-5-carbonitrile and N-(2-amino-5-cyanopyrimidin-4-yl) benzamide derivatives (5–14) were synthesized and their chemical structures were confirmed by 1 H, 13C NMR and mass spectral data. Anticancer activity of all the synthesized compounds were evaluated for in vitro cytotoxic activity against a panel of four human cancer cell lines i.e., human breast (MCF-7,), cervical cancer (C33A), oral (KB) and prostrate (DU-145). All the examined compounds, demonstrated potent to moderate anticancer activity. Among all the synthesized compounds, 6 and 11 were exhibited more potent activity. Docking studies for 6 and 11 into EGFR active site was carried out to investigate their …