Medicine and Health Sciences Commons^™

09-10-19 Hsc Committee Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

10-08-19 Hsc Committee Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

12-09-19 Hsc Committee Meeting Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Oral Development And Breastfeeding: An Assessment Of The Lactation Care Provider Approach, Robin Gatlin

Dental Hygiene ETDs

Breastfeeding influences the infant’s oral development in many ways. Lactation care providers work closely with the mother-infant pair and may be the first to provide information on oral health. The purpose of this study is to assess lactation care provider’s perception, attitude and behavior on the relationship between breastfeeding and oral development; including oral malocclusion, breathing patterns, tethered oral tissues and dental caries. A survey sent to lactation care providers who are members of The United States Lactation Consultant Association. A total of 12 members participated in the survey. Of that, 11 were International Board Certified Lactation Consultants (IBCLCs) and …

Influence Of Metabolic Capacity On The Consequences Of Spreading Depolarization, Katelyn M. Reinhart

Biomedical Sciences ETDs

In the United States, stroke is the fifth leading cause of death and stroke survivors often face long-term disability. After ischemic stroke, the ischemic territory can expand and recruit previously viable tissues into the lesioned area. During this critical period, there is an unsettling lack of interventions that prevent or treat secondary neuronal loss and cognitive decline. Clinical subdural recordings have revealed a close link between infarct progression and waves of spreading depolarizations (SD) in the acutely injured brain. SD is a slowly progressing wave of near-complete neuroglia depolarization that is extremely energetically demanding and this additional metabolic ‘hit’ …

Mechanisms And Consequences Of Myb Gene Activation In Salivary Gland Tumors, Candace Frerich

Biomedical Sciences ETDs

Salivary gland adenoid cystic carcinoma (ACC) is an aggressive tumor with a tendency to infiltrate surrounding nerves and metastasize to distant sites. The standard treatment often fails to control local tumor recurrence and distant metastases and no approved targeted therapeutic options exist for these tumors. The goal of our studies was to reveal the molecular mechanisms driving ACC tumor development and novel drug targets to improve patient morbidity and mortality.

We first analyzed clinical and RNA-sequencing (RNA-seq) data for 68 formalin-fixed paraffin-embedded (FFPE) ACC tumor samples and described previously unappreciated molecular heterogeneity that predicts patient outcome. The poor outcome subgroup …

Hypothyroidism, Sex And Age Predict Future Thromboembolic Events Among Younger People, Supplementary Table 1, Jay A. Martinez, Fares Qeadan, Mark R. Burge

Clinical and Translational Science Center Scholarly Output

This is Supplementary Table 1 for a forthcoming publication in the Journal of Clinical Endocrinology and Metabolism, entitled "Hypothyroidism, Sex and Age Predict Future Thromboembolic Events Among Younger People," by Authors Jay A. Martinez, Fares Qeadan, PhD, and Mark R. Burge, MD

Supplement Table 1: ICD-9 and ICD-10 codes employed in this study for inclusion and exclusion purposes.

12-09-2019 Hsc Committee Meeting Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Neuron Specific Gene 2 (Nsg2): A Novel Regulator Of Excitatory Neurotransmission Via Ampa Receptor Trafficking At A Subset Of Glutamatergic Synapses, Praveen Chander

Biomedical Sciences ETDs

Members of the Neuron-Specific Gene family (NSG1-3) play critical roles in excitatory synaptic transmission via regulation of AMPA receptor surface expression within the post-synaptic density (PSD). While NSG1 and NSG3 regulate AMPAR recycling and endocytosis, respectively, the function of NSG2 has remained elusive. Here we undertook a series of studies to assess the role of NSG2 in excitatory synaptic transmission. We found that a portion of NSG2 punctae localized with HOMER1 and surface AMPARs at excitatory synapses and that NSG2 AMPAR subunits in mouse brain. Knockout of NSG2 selectively impaired the frequency of AMPA mEPSCs, while overexpression caused a significant …

Assessment Of Particulate Matter Toxicity And Physicochemistry At The Claim 28 Uranium Mine Site In Blue Gap, Az, Jessica G. Begay

Biomedical Sciences ETDs

Particulate matter (PM) inhalation is known to have adverse effects on the respiratory and cardiovascular systems. Community concerns in the southwestern US have been expressed in regions of extensive open-pit hard-rock (especially uranium) mining that windblown dusts may pose an excess health risk. To address these concerns, we have undertaken a campaign to detail: (1) the amount and composition of the PM_2.5 in the region, (2) meteorological characteristics, such as wind speed and direction, and (3) and immunological and physiological responses of mice after PM_2.5 exposures.

For toxicity studies, C57BL/6 and apolipoprotein E-null (ApoE^-/-, a vascular …

Chronic Environmental Exposure To Metal Mixtures In Tribal Populations And Potential Immune System Effects, Jennifer Ong

Biomedical Sciences ETDs

Hardrock mining in the United States (US) has left a legacy of mixed metal mine waste sites. Wastes may contain multiple metals of health concern, including arsenic, cadmium, lead, mercury, and uranium, among others. Mining waste sites are disproportionately located on or contiguous to the watersheds of tribal lands. Due to proximity, and because of reliance on natural resources to maintain traditional diets and customs, Native American communities’ contact with multiple metals is often increased. Two impacted communities are the Cheyenne River Sioux Tribe (CRST) and Navajo Nation. Both tribes have expressed concerns that metals in mine waste adversely affect …

The Role Of Omega-3 Polyunsaturated Fatty Acids In Blood Pressure Regulation And Secondhand Smoke-Induced Vascular Dysfunction, Emily Anna Wheeler

Biomedical Sciences ETDs

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) may lower cardiovascular disease risk by reducing blood pressure (BP). We hypothesized that fat-1 transgenic mice, which convert n-6 PUFAs to n-3 PUFAs, would have improved vascular function in BP regulation and following secondhand smoke (SHS) exposure, compared to wild type (WT) mice.

BP was recorded in mice fed an n-6 PUFA, or standard chow diet. On the n-6 PUFA diet fat-1 mice had a lower mean arterial pressure and a greater decrease in diastolic BP when treated with an ACE inhibitor, compared to WT mice. No differences were observed on the chow diet. …

The Role Of Adaptive Immunity In Chronic Hypoxia-Induced Pulmonary Hypertension, Levi David Maston

Biomedical Sciences ETDs

Inflammation is a prominent pathologic feature in pulmonary arterial hypertension as demonstrated by pulmonary vascular infiltration of inflammatory cells, including T and B lymphocytes. However, the contribution of the adaptive immune system is not well characterized in pulmonary hypertension (PH) caused by chronic hypoxia (CH). Inflammatory cells, through various mechanisms, have the capability to increase pulmonary vascular resistance in various disease states. CD4⁺T cells have the potential to play a significant role in the disease process initiated by hypoxia. CD4⁺T cells are largely responsible for orchestrating downstream immune processes and are critical in focusing and amplifying …

10-08-2019 Hsc Committee Meeting Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

10-08-19 Hsc Committee Meeting Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

09-10-2019 Hsc Committee Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

09-10-2019 Hsc Committee Meeting Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Assessment Of The Biocompatibilty, Stability, And Suitability Of Natural And Synthetic Polymers And Drugs In The Fda Approval Process, Phuong Anh Hoang Nguyen

Biomedical Engineering ETDs

Regulation of the development, production, marketing, and sales of medical pharmaceuticals and devices in the United States fall under the regulatory functions of the Food and Drug Administration (FDA). The current FDA approval process takes an average of 10 years from start to completion, and costs over $100 million. As a result, companies use many different methods to find additional use of their drugs through marketing directly to the physician, or recycling of previously approved drug moieties. In this work, an evaluation of the in vitro and ex vivo biocompatibility of polymers and drugs in different phases of FDA approval …

05-07-19 Hsc Committee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

01-08-19 Hsc Committee Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

03-05-19 Hsc Committee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

04-02-19 Hsc Committee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

01-08-19 Hsc Committee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

05-07-19 Hsc Committee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

08-12-19 Hsc Committee Meeting Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

A Hybrid Gis/In Situ Analysis Of Aed Coverage On The Unm Central Campus, Ian T. Hill

Geography ETDs

Automated External Defibrillators (AED’s) are lifesaving devices that can greatly improve the survival rates of cardiac arrest when used quickly. There are publicly accessible AED’s on the UNM campus, and each device has an effective range based on how quickly a responder can retrieve the AED and return it to the site of the cardiac emergency. The ranges of the AED’s on UNM central campus are analyzed using GIS, interior building measurements, and various retrieval speeds. This helps evaluate the current placement of AED’s on campus and helps reveal where future coverage is needed. This focus on the combined navigation …

A Qualitative Examination Of Prostate Cancer Treatment Decision-Making Among Black Men, Linda Ottley

Nursing ETDs

This ethnographic study explored the experience of treatment decision-making among urban Black men who were diagnosed with prostate cancer in San Diego, California. Specifically, this research was conducted to further understand the decision-making process among Black men and the barriers they face when making treatment decisions about prostate cancer. The study is important because prostate cancer disproportionately affects Black men in the United States, and yet they are underrepresented in research studies (Randolph, Coakley, & Shears, 2018). These inequities are poorly understood and need considerable analysis and exploration. Still unclear is the possible effect of historical trauma or negative healthcare …

08-12-19 Hsc Committee Meeting Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Assessment Of Post-Discharge Health Care Utilization In Infants With Neonatal Opioid Withdrawal Syndrome, Shikhar Shrestha

Pharmaceutical Sciences ETDs

Background/Objectives: Children born to mothers with opioid use disorder often show withdrawal effects characterized by increased stress, hyperirritability, tremors, tachycardia, sleep deprivation, and gastrointestinal discomfort, commonly known as “neonatal opioid withdrawal syndrome” (NOWS). Studies have shown that the effect of NOWS can lead to several health-related disorders later in life leading to increased health care utilization. However, detailed study of post-discharge health care utilization, specifically focusing on encounters with the health care system is currently lacking in the literature. Our objective was to evaluate health care utilization in infants who were diagnosed with NOWS during a one-year follow-up period after …

Oral Hygiene In Intensive Care Units: A Survey On Protocol, Kayla J. Gallegos, Christine Nathe

Dental Hygiene ETDs

The purpose of this study was to learn about various Intensive Care Units’ current oral hygiene care protocols, nurses’ values, and interests in interprofessional collaboration with a dental professional. An online survey was created and intended recipients included 1,696 members of the Trauma ICU Nurses/Critical Care Medicine Facebook page. Participants were asked about their value of oral hygiene, oral hygiene education, and interest in interprofessional collaboration. Of the 1,696 nurses 34 (2%) opted to participate in this survey study. Findings from this study suggest that these nurses’ value oral health in themselves and in patients. Half of the survey participants …