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Novel Sphingomyelin Biomarkers For Brain Glioma And Associated Regulation Research On The Pi3k/Akt Signaling Pathway, Xiao-Hui Zhai, Jian Xiao, Jie-Kai Yu, Hong Sun, Shu Zheng

Chemistry and Biochemistry Faculty Research

Glioma is one of the most common malignant tumor types of the central nervous system. It is necessary to identify biomarkers and novel therapeutic targets for glioma. The purpose of the present study was to distinguish lipid biomarkers with differential expression patterns in glioma tissues and normal brain tissues by matrix assisted laser desorption/ionization (MALDI)‑imaging and MALDI‑time of flight (TOF)‑mass spectrometry (MS). Additionally, identification of lipid biomarkers was performed to describe novel therapeutic targets for glioma treatment. A total of six tissues from three patients with glioma and three control patients with traumatic brain injury were analyzed using UltrafleXtreme MALDI‑TOF/TOF. …