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University of Nebraska - Lincoln
Nebraska Center for Virology: Faculty Publications
Dose-dependent response; antibody; T Cell; hemagglutinin; influenza; vaccine; recombinant adenovirus; viral vector
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Dose Effects Of Recombinant Adenovirus Immunization In Rodents, Eric A. Weaver
Dose Effects Of Recombinant Adenovirus Immunization In Rodents, Eric A. Weaver
Nebraska Center for Virology: Faculty Publications
Recombinant adenovirus type 5 (rAd) has been used as a vaccine platform against many infectious diseases and has been shown to be an effective vaccine vector. The dose of the vaccine varies significantly from study to study, making it very diffcult to compare immune responses and vaccine effcacy. This study determined the immune correlates induced by serial dilutions of rAd vaccines delivered intramuscularly (IM) and intranasally (IN) to mice and rats. When immunized IM, mice had substantially higher antibody responses at the higher vaccine doses, whereas, the IN immunized mice showed a lower response to the higher rAd vaccine doses. …