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Perinatal Administration Of Phencyclidine Alters Expression Of Lingo-1 Signaling Pathway Proteins In The Prefrontal Cortex Of Juvenile And Adult Rats, Jessica L. Andrews, Kelly A. Newell, Natalie Matosin, Xu-Feng Huang, Francesca Fernandez-Enright

Illawarra Health and Medical Research Institute

Postnatal administration of phencyclidine (PCP) in rodents causes major brain dysfunction leading to severe disturbances in behavior lasting into adulthood. This model is routinely employed to model psychiatric disorders such as schizophrenia, as it reflects schizophrenia related brain disturbances in cluding increased apoptosis, a nd disruptions to myelin and plasticity processes. Leucine -rich repeat and immunoglobulin domain-containing protein, Lingo-1, is a potent negative regulator of both axonal myelination and neurite extension. The Nogo receptor (NgR)/TNF receptor orphan Y (T ROY) and/or p75 complex, With No Lysine (K) (WNK1) and Myelin transcription factor-1 (Myt1) are co-receptors or co-factors in Lingo- 1 …