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Full-Text Articles in Medicine and Health Sciences
Determining The Effects Of Cancer Mutations On The Coactivator Function Of The P300 Core Domain In Human Cells, Katlyn Myers, Erin Shanle, Meagan St. John
Determining The Effects Of Cancer Mutations On The Coactivator Function Of The P300 Core Domain In Human Cells, Katlyn Myers, Erin Shanle, Meagan St. John
Selected Publications
In human cells, DNA is packed into chromosomes by wrapping around proteins called histones. Histone proteins contain chains of amino acids called histone tails and can be modified by acetylation. Acetylating histone proteins is important to the cell because it opens up the chromatin and allows for gene expression. Proteins can recognize and bind histone acetylation with a region called a bromodomain. p300 is a bromodomain-containing protein with histone acetyltransferase activity (HAT) which also aids with gene expression and is a coactivator protein of transcription. The bromodomain and HAT domain of this protein is considered the p300 core. Previous research …
Recent Incidences And Trends Of The Top Five Cancers In Northeast Appalachian Tennessee, Adekunle Oke, Sylvester Olubolu Orimaye, Ndukwe Kalu, Faustine Williams
Recent Incidences And Trends Of The Top Five Cancers In Northeast Appalachian Tennessee, Adekunle Oke, Sylvester Olubolu Orimaye, Ndukwe Kalu, Faustine Williams
Appalachian Student Research Forum
Introduction: Cancer is the second leading cause of death in the United States (U.S.), after cardiovascular disease. Although there has been a continuous decline in cancer mortality rates in the U.S. over the past two decades, the Appalachian region, which extends through 13 states and 420 counties in the southeastern part of the U.S., has seen a lower decline in cancer mortality. From 1980-2014, cancer deaths decreased by almost 45%, but cancer mortality rates in rural Appalachia was 36% higher than for urban non-Appalachian counties. In terms of cancer-specific, although breast cancer mortality rates have also decreased significantly nationally, a …