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Full-Text Articles in Medicine and Health Sciences
Exploring The Role Of Mirnas In The Diagnosis Of Mody3, Oğuzhan Fati̇h Baltaci, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Nesli̇han Aydin, Mehmet Sarğin, Arzu Karabay Korkmaz, Mehmet Temel Yilmaz, Ergül Berber
Exploring The Role Of Mirnas In The Diagnosis Of Mody3, Oğuzhan Fati̇h Baltaci, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Nesli̇han Aydin, Mehmet Sarğin, Arzu Karabay Korkmaz, Mehmet Temel Yilmaz, Ergül Berber
Turkish Journal of Medical Sciences
Background/aim: MODY3 associated with HNF1A is the most common form of MODY and is clinically misdiagnosed as type 1 diabetes due to similar clinical symptoms. This study aimed to analyze the role of HNF1A-regulated miRNAs as a biomarker in the diagnosis of MODY3. Materials and methods: MIN6 cells were transfected with the HNF1A cDNA expression vector for overexpression or with siRNA specific to HNF1A to silence its expression. The HNF1A-regulated miRNAs were determined by RNA-Seq of the total RNA extract. Expressions of the candidate miRNAs in blood samples of MODY3, type 1 diabetes, and type 2 diabetes patients and in …
Emerging Biomarker For Predicting Acute Kidney Injuryafter Cardiac Surgery: Cystatin C, Onur Saydam, Ercan Türkmen, Oytun Portakal Akçi̇n, Mustafa Arici, Riza Doğan, Meti̇n Demi̇rci̇n, İlhan Paşaoğlu, Mustafa Yilmaz
Emerging Biomarker For Predicting Acute Kidney Injuryafter Cardiac Surgery: Cystatin C, Onur Saydam, Ercan Türkmen, Oytun Portakal Akçi̇n, Mustafa Arici, Riza Doğan, Meti̇n Demi̇rci̇n, İlhan Paşaoğlu, Mustafa Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Cardiopulmonary bypass (CPB)-associated acute kidney injury (AKI) is a common situation and rapid diagnosis and risk classification are important in the prevention and management of AKI. Changes in serum creatinine (SCr) levels in the current consensus criteria do not allow clinicians to diagnose CPB-associated AKI until 48 h after surgery. Materials and methods: We conducted a prospective single center study involving 57 patients who underwent cardiac surgery with CBP to compare serum beta-trace protein (BTP), neutrophil gelatinase-associated lipocalin-2 (NGAL), and cystatin C (CysC) levels with SCr for early diagnosis of CPB associated AKI. We defined AKI according to KDIGO …
The Role Of Soluble Urokinase Plasminogen Activator Receptor (Supar) As An Indicator Of The Severity Of Acute Pancreatitis, Kadi̇r Küçükceran, Mehmet Ergi̇n, İbrahi̇m Kilinç, Adnan Karai̇brahi̇moğlu, Tamer Çolak, Alpay Tuncar, Zerri̇n Defne Dündar, Sedat Koçak, Abdullah Sadik Gi̇ri̇şgi̇n, Mehmet Gül, Başar Cander
The Role Of Soluble Urokinase Plasminogen Activator Receptor (Supar) As An Indicator Of The Severity Of Acute Pancreatitis, Kadi̇r Küçükceran, Mehmet Ergi̇n, İbrahi̇m Kilinç, Adnan Karai̇brahi̇moğlu, Tamer Çolak, Alpay Tuncar, Zerri̇n Defne Dündar, Sedat Koçak, Abdullah Sadik Gi̇ri̇şgi̇n, Mehmet Gül, Başar Cander
Turkish Journal of Medical Sciences
Background/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with the activation degree of the immune system. This study's aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP) patients in determining the severity of disease. Materials and methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, had nontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Demographic characteristics, contact information, laboratory and imaging test parameters, Ranson's criteria, the Balthazar Severity Index, the Rapid Acute Physiologic Score (RAPS), …