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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Multi-Nuclear Magnetic Resonance Imaging Of Obstructive Lung Disease, Khadija Sheikh
Multi-Nuclear Magnetic Resonance Imaging Of Obstructive Lung Disease, Khadija Sheikh
Electronic Thesis and Dissertation Repository
Obstructive lung diseases such as chronic-obstructive-lung-disease (COPD), bronchiectasis, and asthma are characterized by airflow obstruction. They affect over six million Canadians costing the economy $12 billion/year. Despite decades of research, therapies that modify obstructive-lung-disease progression and control are lacking because patient diagnosis, monitoring, and response to therapy are currently made using airflow measurements that may conceal the independent contributions of underlying pathologies. One goal of obstructive-lung-disease research is to develop ways to identify patients with specific underlying pathological phenotypes to improve patient care and outcomes. Thoracic computed-tomography (CT) and magnetic-resonance-imaging (MRI) provide ways to regionally identify the underlying pathologies associated …
Vacht Overexpression Increases Acetylcholine At The Synaptic Cleft And Accelerates Aging Of Neuromuscular Junctions, Satoshi Sugita, Leland L. Fleming, Caleb Wood, Sydney K. Vaughan, Matheus P. S. M. Gomes, Wallace Camargo, Ligia A. Naves, Vania F. Prado, Marco A. M. Prado, Cristina Guatimosim, Gregorio Valdez
Vacht Overexpression Increases Acetylcholine At The Synaptic Cleft And Accelerates Aging Of Neuromuscular Junctions, Satoshi Sugita, Leland L. Fleming, Caleb Wood, Sydney K. Vaughan, Matheus P. S. M. Gomes, Wallace Camargo, Ligia A. Naves, Vania F. Prado, Marco A. M. Prado, Cristina Guatimosim, Gregorio Valdez
Anatomy and Cell Biology Publications
Background: Cholinergic dysfunction occurs during aging and in a variety of diseases, including amyotrophic lateral sclerosis (ALS). However, it remains unknown whether changes in cholinergic transmission contributes to age-and disease-related degeneration of the motor system. Here we investigated the effect of moderately increasing levels of synaptic acetylcholine (ACh) on the neuromuscular junction (NMJ), muscle fibers, and motor neurons during development and aging and in a mouse model for amyotrophic lateral sclerosis (ALS). Methods: Chat-ChR2-EYFP (VAChTHyp) mice containing multiple copies of the vesicular acetylcholine transporter (VAChT), mutant superoxide dismutase 1 (SOD1G93A), and Chat-IRES-Cre and tdTomato transgenic mice were used in this …
The Effects Of Manual Tooth Brushing On Parotid And Submandibular/Sublingual Gland Salivary Flow Rates In Healthy Young And Older Adults, Kristen M. Trottier
The Effects Of Manual Tooth Brushing On Parotid And Submandibular/Sublingual Gland Salivary Flow Rates In Healthy Young And Older Adults, Kristen M. Trottier
Electronic Thesis and Dissertation Repository
Saliva is crucial for the maintenance of oral health. Individuals with reduced salivary flow may experience a distortion in taste, difficulty swallowing, and impaired articulation of speech. Research has shown that tooth brushing increases whole salivary flow rates in older adults. It is important to determine whether this increase results from the modulation of parotid gland salivary flow, submandibular and sublingual gland salivary flow, or both. Saliva produced from the parotid gland aids in digestive processes, while saliva secreted from the submandibular and sublingual glands promotes protection of the oral cavity. A within-subjects methodology was used to examine the effects …
The Phenomenology Of Masters Alpine Ski Racers: Experiencing Ski Racing In Old Age, Carly Litchfield
The Phenomenology Of Masters Alpine Ski Racers: Experiencing Ski Racing In Old Age, Carly Litchfield
Electronic Thesis and Dissertation Repository
This thesis is a study of the lived experience of ten older adult alpine ski racers in their continued participation in ski racing. The aim of this study was to gain an understanding of the experiences of these older adults as they continued to compete in ski racing. Masters skiers between the ages of 69 and 82 participated in individual interviews lasting between 30 and 60 minutes. Data analysis was completed using van Manen’s phenomenological methods and the visual technique of mind mapping. The major theme that emerged was the importance of being a ski racer to participants’ identities. The …
Hip Fracture Types In Canadian Men And Women Change Differently With Age: A Population-Level Analysis, Richard G. Crilly, Marita Kloseck, Selam Mequanint
Hip Fracture Types In Canadian Men And Women Change Differently With Age: A Population-Level Analysis, Richard G. Crilly, Marita Kloseck, Selam Mequanint
Bone and Joint Institute
© the authors, publisher and licensee Libertas Academica Limited. Background: We have previously reported a gender difference in the occurrence of hip fracture type with age in our local population. In the current report, we have explored this phenomenon in a Canadian population using five years of data from a national administrative database. We have com-pared community-dwelling and institutionalized individuals to determine if frailty is important and has a differential effect on the type of hip fracture experienced.Methods: Hospitalization records from 2005 to 2009, in which the most responsible diagnosis, that is the diagnosis causing the admission to hospital, was …
Category Learning In Older Adulthood: A Study Of The Shepard, Hovland, And Jenkins (1961) Tasks., Rahel Rabi, John Paul Minda
Category Learning In Older Adulthood: A Study Of The Shepard, Hovland, And Jenkins (1961) Tasks., Rahel Rabi, John Paul Minda
Brain and Mind Institute Researchers' Publications
Shepard, Hovland, and Jenkins (1961) examined the categorization abilities of younger adults using tasks involving single-dimensional rule learning, disjunctive rule learning, and family resemblance learning. The current study examined category learning in older adults using this well-known category set. Older adults, like younger adults, found category tasks with a single relevant dimension the easiest to learn. In contrast to younger adults, older adults found complex disjunctive rule-based categories harder to learn than family resemblance based categories. Disjunctive rule-based category learning appeared to be the most difficult for older adults to learn because this category set placed the heaviest demands on …
“Why Would I Want To Go Out?”: Age-Related Vision Loss And Social Participation, Debbie Rudman, Deborah Gold, Colleen Mcgrath, Biljana Zuvela, Marlee Spafford, Rebecca Renwick
“Why Would I Want To Go Out?”: Age-Related Vision Loss And Social Participation, Debbie Rudman, Deborah Gold, Colleen Mcgrath, Biljana Zuvela, Marlee Spafford, Rebecca Renwick
Occupational Therapy Publications
Social participation, a key determinant of healthy aging, is often negatively impacted by age-related vision loss (ARVL). This grounded theory study aimed to understand social participation as a process negotiated in everyday life by older adults with ARVL. Interviews, audio diaries, and life-space maps were used to collect data with 21 older adults in two Ontario cities. Inductive data analysis resulted in a transactional model of the process of negotiating social participation in context. This model depicts how environmental features and resources, skills and abilities, and risks and vulnerabilities transacted with values and priorities to affect if and how social …