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Full-Text Articles in Medicine and Health Sciences
Balloon Valvuloplasty For Pulmonic Stenosis In Two Dogs: Case Report, Chollada Buranakarl, Anusak Kijtawornrat, Wasan Udayachalerm, Sirilak Disatian Surachetpong, Saikaew Sutayatram, Pasakorn Briksawan, Sumit Durongpongtorn, Rampaipat Tungjitpeanpong, Nardtiwa Chaivoravitsakul
Balloon Valvuloplasty For Pulmonic Stenosis In Two Dogs: Case Report, Chollada Buranakarl, Anusak Kijtawornrat, Wasan Udayachalerm, Sirilak Disatian Surachetpong, Saikaew Sutayatram, Pasakorn Briksawan, Sumit Durongpongtorn, Rampaipat Tungjitpeanpong, Nardtiwa Chaivoravitsakul
The Thai Journal of Veterinary Medicine
Balloon valvuloplasty for correction of congenital pulmonic stenosis (PS) in two dogs by intervention technique was first reported in Thailand. Both dogs did not show any clinical signs related to congestive heart failure. Physical examination in both dogs revealed heart murmur. Electrocardiographs of both dogs were recorded and showed normal sinus rhythm with deep S wave. In the first dog, thoracic radiograph revealed cardiomegaly with enlargement of the main pulmonary artery and left deviation of the apex due to right ventricular enlargement. Definitive diagnosis of PS was performed by echocardiography. Computed tomography (CT) of both dogs demonstrated stenosis of the …
Effectiveness Of Disease Modifying Osteoarthritis Agents And Carprofen For Treatment Of Canine Osteoarthritis, Irin Kwananocha, Monchanok Vijarnsorn, Narudee Kashemsant, Chalermpol Lekcharoensuk
Effectiveness Of Disease Modifying Osteoarthritis Agents And Carprofen For Treatment Of Canine Osteoarthritis, Irin Kwananocha, Monchanok Vijarnsorn, Narudee Kashemsant, Chalermpol Lekcharoensuk
The Thai Journal of Veterinary Medicine
A prospective, randomized, single-blinded study was conducted to evaluate and compare the effectiveness of disease modifying osteoarthritis agents (DMOAAs) and carprofen by using force plate gait analysis and orthopaedic assessment score (OAS) in osteoarthritic dogs. Forty dogs with hip and/or stifle osteoarthritis (OA) were assigned randomly into four treatment groups: PCSO-524, treated with a marine-based fatty-acid compound; GC-ASU, treated with a combination of glucosamine-chondroitin sulphate and avocado/soybean unsaponifiables; CPF, treated with carprofen; and CPF-PCSO, treated with a combination of carprofen and PCSO-524. Each group received the therapeutic agent orally for four weeks. Peak vertical force (PVF), OAS, haematology and blood …
Ameliorative Effects Of Omega-3 Concentrate In Managing Coxofemoral Osteoarthritic Pain In Dogs, Amornrate Sastravaha, Nirut Suwanna, Chayakrit Sinthusingha, Jatuporn Noosud, Atthaporn Roongsitthichai
Ameliorative Effects Of Omega-3 Concentrate In Managing Coxofemoral Osteoarthritic Pain In Dogs, Amornrate Sastravaha, Nirut Suwanna, Chayakrit Sinthusingha, Jatuporn Noosud, Atthaporn Roongsitthichai
The Thai Journal of Veterinary Medicine
The aim of the present study was to investigate the effect of omega-3 concentrate on pain management in dogs with osteoarthritis (OA) at the coxofemoral joint. Totally, 31 dogs with confirmed coxofemoral OA were orthopedically evaluated for pain scores at walk and trot (1-6), joint manipulation (1-3), and examining range of motion (1-4). Besides, blood collection was performed on the first and the last visits. Omega-3 concentrate was orally given to all dogs at one capsule per 10 kgBW since the first visit on a daily basis for four consecutive weeks. On a weekly basis, pain scores were assessed for …
Comparison Of Protein Phosphatase Inhibition Assay With Lc-Ms/Ms For Diagnosis Of Microcystin Toxicosis In Veterinary Cases, Caroline E. Moore, Jeanette Juan, Yanping Lin, Cynthia L. Gaskill, Birgit Puschner
Comparison Of Protein Phosphatase Inhibition Assay With Lc-Ms/Ms For Diagnosis Of Microcystin Toxicosis In Veterinary Cases, Caroline E. Moore, Jeanette Juan, Yanping Lin, Cynthia L. Gaskill, Birgit Puschner
Veterinary Diagnostic Laboratory Faculty Publications
Microcystins are acute hepatotoxins of increasing global concern in drinking and recreational waters and are a major health risk to humans and animals. Produced by cyanobacteria, microcystins inhibit serine/threonine protein phosphatase 1 (PP1). A cost-effective PP1 assay using p-nitrophenyl phosphate was developed to quickly assess water and rumen content samples. Significant inhibition was determined via a linear model, which compared increasing volumes of sample to the log-transformed ratio of the exposed rate over the control rate of PP1 activity. To test the usefulness of this model in diagnostic case investigations, samples from two veterinary cases were tested. In August …
Seroprevalence Of Influenza A In Domestic Dogs In Thailand, 2013, Sunicha Chanvatik, Ratanaporn Tangwangvivat, Supassama Chaiyawong, Duangduean Prakairungnamthip, Ranida Tuanudom, Aunyaratana Thontiravong, Alongkorn Amonsin
Seroprevalence Of Influenza A In Domestic Dogs In Thailand, 2013, Sunicha Chanvatik, Ratanaporn Tangwangvivat, Supassama Chaiyawong, Duangduean Prakairungnamthip, Ranida Tuanudom, Aunyaratana Thontiravong, Alongkorn Amonsin
The Thai Journal of Veterinary Medicine
Canine influenza viruses (CIVs) have been reported in dogs worldwide. Due to the relatively high risk of influenza A virus (IAV) infections in dogs and humans through dog-human interface, the seroprevalence of IAVs in dogs in Thailand was surveyed. A serological survey of IAV infections in dogs in Thailand was conducted from December 2012 to November 2013 using ELISA assays for detecting anti-nucleoprotein (NP) antibodies (NP-ELISA) and hemagglutination inhibition (HI) tests for detecting HA-specific antibodies using canine H3N2 (CIV-H3N2), human pandemic H1N1 2009 (Human-pH1N1) and human seasonal H3N2 (Human-H3N2) as viral antigens. A total of 9,891 serum samples were obtained …
Window Into Retinal Studies, Gustavo D. Aguirre
Window Into Retinal Studies, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
Professor Gustavo Aguirre discusses the context of his research studies at the University of Pennsylvania, which are currently concentrating on the degenerative disease, retinitis pigmentosa.
Safety In Nonhuman Primates Of Ocular Aav2-Rpe65, A Candidate Treatment For Blindness In Leber Congenital Amaurosis, Samuel G. Jacobson, Sanford L. Boye, Tomas S. Aleman, Thomas J. Conlon, Caroline J. Zeiss, Alejandro J. Roman, Artur V. Cideciyan, Sharon B. Schwartz, András M. Komáromy, Michelle Doobrajh, Andy Y. Cheung, Alexandar Sumaroka, Susan E. Pearce-Kelling, Gustavo D. Aguirre, Shalesh Kaushal, Albert M. Maguire, Terence R. Flotte, William W. Hauswirth
Safety In Nonhuman Primates Of Ocular Aav2-Rpe65, A Candidate Treatment For Blindness In Leber Congenital Amaurosis, Samuel G. Jacobson, Sanford L. Boye, Tomas S. Aleman, Thomas J. Conlon, Caroline J. Zeiss, Alejandro J. Roman, Artur V. Cideciyan, Sharon B. Schwartz, András M. Komáromy, Michelle Doobrajh, Andy Y. Cheung, Alexandar Sumaroka, Susan E. Pearce-Kelling, Gustavo D. Aguirre, Shalesh Kaushal, Albert M. Maguire, Terence R. Flotte, William W. Hauswirth
Gustavo D. Aguirre, VMD, PhD
Leber congenital amaurosis (LCA) is a molecularly heterogeneous disease group that leads to blindness. LCA caused by RPE65 mutations has been studied in animal models and vision has been restored by subretinal delivery of AAV- RPE65 vector. Human ocular gene transfer trials are being considered. Our safety studies of subretinal AAV-2/2. RPE65 in RPE65 -mutant dogs showed evidence of modest photoreceptor loss in the injection region in some animals at higher vector doses. We now test the hypothesis that there can be vector-related toxicity to the normal monkey, with its human-like retina. Good Laboratory Practice safety studies following single intraocular …
Photoreceptor Cell Death, Proliferation And Formation Of Hybrid Rod/S-Cone Photoreceptors In The Degenerating Stk38l Mutant Retina, Ágnes I. Berta, Kathleen Boesze-Battaglia, Sem Genini, Orly Goldstein, Paul J. O'Brien, Ágoston Szél, Gregory M. Acland, William Beltran, Gustavo D. Aguirre
Photoreceptor Cell Death, Proliferation And Formation Of Hybrid Rod/S-Cone Photoreceptors In The Degenerating Stk38l Mutant Retina, Ágnes I. Berta, Kathleen Boesze-Battaglia, Sem Genini, Orly Goldstein, Paul J. O'Brien, Ágoston Szél, Gregory M. Acland, William Beltran, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
A homozygous mutation in STK38L in dogs impairs the late phase of photoreceptor development, and is followed by photoreceptor cell death (TUNEL) and proliferation (PCNA, PHH3) events that occur independently in different cells between 7–14 weeks of age. During this period, the outer nuclear layer (ONL) cell number is unchanged. The dividing cells are of photoreceptor origin, have rod opsin labeling, and do not label with markers specific for macrophages/microglia (CD18) or Müller cells (glutamine synthetase, PAX6). Nestin labeling is absent from the ONL although it labels the peripheral retina and ciliary marginal zone equally in normals and mutants. Cell …
Identical Mutation In A Novel Retinal Gene Causes Progressive Rod-Cone Degeneration In Dogs And Retinitis Pigmentosa In Humans, Barbara Zangerl, Orly Goldstein, Alisdair R. Philip, Sarah J. P Lindauer, Susan E. Pearce-Kelling, Roberts F. Mullins, Alexander S. Graphodatsky, Daniel Ripoll, Jeanette S. Felix, Edwin M. Stone, Gregory M. Acland, Gustavo D. Aguirre
Identical Mutation In A Novel Retinal Gene Causes Progressive Rod-Cone Degeneration In Dogs And Retinitis Pigmentosa In Humans, Barbara Zangerl, Orly Goldstein, Alisdair R. Philip, Sarah J. P Lindauer, Susan E. Pearce-Kelling, Roberts F. Mullins, Alexander S. Graphodatsky, Daniel Ripoll, Jeanette S. Felix, Edwin M. Stone, Gregory M. Acland, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
Progressive rod–cone degeneration (prcd) is a late-onset, autosomal recessive photoreceptor degeneration of dogs and a homolog for some forms of human retinitis pigmentosa (RP). Previously, the disease-relevant interval was reduced to a 106-kb region on CFA9, and a common phenotype-specific haplotype was identified in all affected dogs from several different breeds and breed varieties. Screening of a canine retinal EST library identified partial cDNAs for novel candidate genes in the disease-relevant interval. The complete cDNA of one of these, PRCD, was cloned in dog, human, and mouse. The gene codes for a 54-amino-acid (aa) protein in dog and human and …
Long-Term Restoration Of Rod And Cone Vision By Single Dose Raav-Mediated Gene Transfer To The Retina In A Canine Model Of Childhood Blindness, Gregory M. Acland, Gustavo D. Aguirre, Jean Bennett, Tomas S. Aleman, Artur V. Cideciyan, Jeannette Bennicelli, Nadine S. Dejneka, Susan E. Pearce-Kelling, Albert M. Maguire, Krzysztof Palczewski, William W. Hauswirth, Samuel G. Jacobson
Long-Term Restoration Of Rod And Cone Vision By Single Dose Raav-Mediated Gene Transfer To The Retina In A Canine Model Of Childhood Blindness, Gregory M. Acland, Gustavo D. Aguirre, Jean Bennett, Tomas S. Aleman, Artur V. Cideciyan, Jeannette Bennicelli, Nadine S. Dejneka, Susan E. Pearce-Kelling, Albert M. Maguire, Krzysztof Palczewski, William W. Hauswirth, Samuel G. Jacobson
Gustavo D. Aguirre, VMD, PhD
The short- and long-term effects of gene therapy using AAV-mediated RPE65 transfer to canine retinal pigment epithelium were investigated in dogs affected with disease caused by RPE65 deficiency. Results with AAV 2/2, 2/1, and 2/5 vector pseudotypes, human or canine RPE65 cDNA, and constitutive or tissue-specific promoters were similar. Subretinally administered vectors restored retinal function in 23 of 26 eyes, but intravitreal injections consistently did not. Photoreceptoral and postreceptoral function in both rod and cone systems improved with therapy. In dogs followed electroretinographically for 3 years, responses remained stable. Biochemical analysis of retinal retinoids indicates that mutant dogs have no …
Occurrence Of Arcobacter In Dogs And Cats In Selangor,Malaysia, And Associated Risk Factors, Dauda Mohammed Goni, Saleha Abdulaziz, Gurmeet Kaur Dhaliwa, Zunita Zakaria, Ibrahim Jalo Muhammad, Mohamed Abdelrahman Mohamed, Abdulrasheed Aliyu Bello, Asinamai Athliamai Bitrus
Occurrence Of Arcobacter In Dogs And Cats In Selangor,Malaysia, And Associated Risk Factors, Dauda Mohammed Goni, Saleha Abdulaziz, Gurmeet Kaur Dhaliwa, Zunita Zakaria, Ibrahim Jalo Muhammad, Mohamed Abdelrahman Mohamed, Abdulrasheed Aliyu Bello, Asinamai Athliamai Bitrus
Turkish Journal of Veterinary & Animal Sciences
Arcobacter is widely regarded as an emerging foodborne pathogen because of its increasing occurrence in food production causing gastroenteritis in humans. In addition, it is also reported as a potential zoonosis. The objectives of this study were to determine the occurrence of Arcobacter in dogs and cats and the associated risk factors. Rectal and buccal cavity swab samples were taken from dogs (n = 40) and cats (n = 40) owned by individuals who brought the animals to a university teaching hospital and stray dogs (n = 61) and cats (n = 46). Suspected colonies of Arcobacter were subjected to …
Protective Effects Of S-Adenosylmethionine (Same) And Silybin On Hepatorenal And Hemostatic Functions In Dogs With Endotoxemia, Meri̇ç Kocatürk, Oya Eralp İnan, Pinar Levent, Zeki̇ Yilmaz
Protective Effects Of S-Adenosylmethionine (Same) And Silybin On Hepatorenal And Hemostatic Functions In Dogs With Endotoxemia, Meri̇ç Kocatürk, Oya Eralp İnan, Pinar Levent, Zeki̇ Yilmaz
Turkish Journal of Veterinary & Animal Sciences
We aimed to investigate the protective effects of S-adenosylmethionine (SAMe) and silybin treatment on hepatorenal and hemostatic functions in dogs with endotoxemia. Healthy dogs (n = 20) were divided equally into 4 groups as control, SAMe + silybin (SS), lipopolysaccharide (LPS), and LPS + SS. Controls received 0.9% NaCl intravenously. Animals were treated daily with 20 mg of SAMe and 1 mg of silybin per kilogram of body weight in SS and LPS + SS. LPS was injected (2 μg/kg, once intravenously) to dogs in LPS and LPS + SS. Hemostatic functions were assessed by thromboelastography (TEG). LPS-induced clinical and …
Ultrasonographic Features Of Medial Iliac And Jejunal Lymph Nodesin Apparently Healthy Dogs, Shriram Ganesan, Jitender Mohindroo, Pallavi Verma, Narinder Singh Saini
Ultrasonographic Features Of Medial Iliac And Jejunal Lymph Nodesin Apparently Healthy Dogs, Shriram Ganesan, Jitender Mohindroo, Pallavi Verma, Narinder Singh Saini
Turkish Journal of Veterinary & Animal Sciences
Ultrasonographic examination of medial iliac and jejunal lymph nodes were performed in 36 dogs presented to the Department of Surgery and Radiology for spaying and castration. Ultrasonographic features such as length, height in longitudinal plane, shape, ease of scanning, echotexture, and echogenicity were recorded. The medial iliac and jejunal lymph nodes were scanned consistently in all 36 dogs. However, the presence of gas in the intestines affected the ease of scanning of the lymph nodes. The majority of these lymph nodes were easy to scan, and had homogeneous and hypoechoic echogenicity. The dogs were grouped based on body weight and …